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Gucy1a2 Gene Detail
Summary
  • Symbol
    Gucy1a2
  • Name
    guanylate cyclase 1, soluble, alpha 2
  • Synonyms
    6330407I18Rik, A230060L24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2660877
    NCBI Gene: 234889
  • Gene Overview
    MyGene.info: GUCY1A2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:3532778-3894736 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    699 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2660877
protein coding gene Chr9:3532349-3905791 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034307
protein coding gene Chr9:228928-586743 (+)
A/J MGP_AJ_G0034284
protein coding gene Chr9:373340-767339 (+)
AKR/J MGP_AKRJ_G0034214
protein coding gene Chr9:264597-623574 (+)
BALB/cJ MGP_BALBcJ_G0034278
protein coding gene Chr9:223893-579829 (+)
C3H/HeJ MGP_C3HHeJ_G0033990
protein coding gene Chr9:375091-750380 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034800
protein coding gene Chr9:332078-721539 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031738
protein coding gene Chr9:151317-422242 (+)
CAST/EiJ MGP_CASTEiJ_G0033317
protein coding gene Chr9:486333-834869 (+)
CBA/J MGP_CBAJ_G0033962
protein coding gene Chr9:230200-630100 (+)
DBA/2J MGP_DBA2J_G0034119
protein coding gene Chr9:378284-726721 (+)
FVB/NJ MGP_FVBNJ_G0034064
protein coding gene Chr9:214040-565947 (+)
LP/J MGP_LPJ_G0034206
protein coding gene Chr9:232867-610558 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034108
protein coding gene Chr9:399249-931337 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034819
protein coding gene Chr9:210855-598146 (+)
PWK/PhJ MGP_PWKPhJ_G0033021
protein coding gene Chr9:507022-867389 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032858
protein coding gene Chr9:526973-871280 (+)
WSB/EiJ MGP_WSBEiJ_G0033433
protein coding gene Chr9:233974-610665 (+)



Homology
more
  • Human Ortholog
    GUCY1A2, guanylate cyclase 1 soluble subunit alpha 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GUCY1A2, guanylate cyclase 1 soluble subunit alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GC-SA2, GUC1A2
  • Links
    NCBI Gene ID: 2977
    neXtProt AC: NX_P33402
    UniProt: P33402

  • Chr Location
    11q22.3; chr11:106674012-107018445 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a null mutation display normal blood vessel and platelet physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041624 Ensembl Gene Model | MGI Sequence Detail 361959 C57BL/6J ±  kb
transcript ENSMUST00000115733 Ensembl | MGI Sequence Detail 2243 Not Applicable  
polypeptide ENSMUSP00000111398 Ensembl | MGI Sequence Detail 730 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
    IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
    IPR011645 Haem NO binding associated
    IPR011644 Heme NO-binding
    IPR038158 H-NOX domain superfamily
    IPR024096 NO signalling/Golgi transport ligand-binding domain superfamily
    IPR029787 Nucleotide cyclase
Molecular
Reagents
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  • All nucleic 21
    cDNA 19
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:1917960, MGI:2444229
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:222464 Neitz A, et al., Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Cereb Cortex. 2014 Jul;24(7):1923-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory