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Gucy1a2
Gene Detail
Symbol

Name
ID
Gucy1a2
guanylate cyclase 1, soluble, alpha 2
MGI:2660877
Synonyms
6330407I18Rik, A230060L24Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:3532354-3897342 bp, + strand
From Ensembl annotation of GRCm38

  364989 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47953  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Gucy1a2

Human
homologs
Human Homolog GUCY1A2, guanylate cyclase 1, soluble, alpha 2
NCBI Gene ID 2977
neXtProt AC  NX_P33402
Human Synonyms  GC-SA2, GUC1A2
Human Chr (Location)  11q21-q22; chr11:106674012-107018445 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display normal blood vessel and platelet physiology.
 
Interactions
Gucy1a2 interacts with 356 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process cGMP biosynthetic process, positive regulation of cGMP biosynthetic process
Function guanylate cyclase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (96)    Tissues (96)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 2
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000041624 (Evidence)
Entrez Gene234889 (Evidence)
UniGene91240
DFCITC1598113, TC1614895, TC1619432, TC1660888, TC1670310, TC1697727
DoTSDT.101130757, DT.110612885, DT.55227028, DT.94132554, DT.94189319, DT.94292847
NIA Mouse Gene IndexU010005, U218245, U229715
Consensus CDS ProjectCCDS40526.1
International Mouse Knockout Project StatusGucy1a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041624 Ensembl Gene Model | MGI Sequence Detail 364989 C57BL/6J ±  kb
transcript ENSMUST00000115733 Ensembl | MGI Sequence Detail 5273 Not Applicable 
polypeptide ENSMUSP00000111398 Ensembl | MGI Sequence Detail 730 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(3) UniProt(6)
Polymorphisms
SNPs within 2kb(757 from dbSNP Build 137)    SNPs within 2kb including multiple locations(771)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR011645 Haem NO binding associated
InterPro IPR011644 Heme-NO binding
InterPro IPR024096 NO signalling/Golgi transport ligand-binding domain
Protein Ontology PR:000008348 guanylate cyclase soluble subunit alpha-2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:177324 Neitz A, et al., Presynaptic nitric oxide/cGMP facilitates glutamate release via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Eur J Neurosci. 2011 May;33(9):1611-21
All references(33)
Other
accession IDs
MGI:1917960, MGI:2444229

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory