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Gucy1b2 Gene Detail
Summary
  • Symbol
    Gucy1b2
  • Name
    guanylate cyclase 1, soluble, beta 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2660873
    NCBI Gene: 239134
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:62630125-62693738 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2167 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2660873
 protein coding gene Chr14:62610384-62693745 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021446
 protein coding gene Chr14:56829798-56902916 (-)
A/J MGP_AJ_G0021405
 protein coding gene Chr14:55567165-55629574 (-)
AKR/J MGP_AKRJ_G0021381
 protein coding gene Chr14:57551916-57615548 (-)
BALB/cJ MGP_BALBcJ_G0021411
 protein coding gene Chr14:55519839-55585659 (-)
C3H/HeJ MGP_C3HHeJ_G0021188
 protein coding gene Chr14:57172889-57240832 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021850
 protein coding gene Chr14:59556702-59626544 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019390
 protein coding gene Chr14:53535026-53601517 (-)
CAST/EiJ MGP_CASTEiJ_G0020705
 protein coding gene Chr14:53600566-53669297 (-)
CBA/J MGP_CBAJ_G0021155
 protein coding gene Chr14:61302715-61375388 (-)
DBA/2J MGP_DBA2J_G0021278
 protein coding gene Chr14:55236154-55299153 (-)
FVB/NJ MGP_FVBNJ_G0021257
 protein coding gene Chr14:54649949-54715063 (-)
LP/J MGP_LPJ_G0021353
 protein coding gene Chr14:57872153-57941144 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021286
 protein coding gene Chr14:60609677-60678625 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021873
 protein coding gene Chr14:56694370-56760684 (-)
PWK/PhJ MGP_PWKPhJ_G0020449
 protein coding gene Chr14:51908497-51977827 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020282
 protein coding gene Chr14:52670416-52731358 (-)
WSB/EiJ MGP_WSBEiJ_G0020758
 protein coding gene Chr14:57013111-57086659 (-)



Homology
more
  • Human Ortholog
    GUCY1B2, guanylate cyclase 1 soluble subunit beta 2 (pseudogene)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GUCY1B2, guanylate cyclase 1 soluble subunit beta 2 (pseudogene)
  • Synonyms
    GC-SB2, GUCY1B2P
  • Links
    NCBI Gene ID: 2974

  • Chr Location
    13q14.3; chr13:50994505-51080862 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    7 phenotype references
Mice homozygous for a knock-out allele exhibit a normal hyperventilation response to a 10% oxygen environment.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    97
  • cDNA Data
    10
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021933 Ensembl Gene Model | MGI Sequence Detail 63614 C57BL/6J ±  kb
transcript ENSMUST00000022501 Ensembl | MGI Sequence Detail 2711 Not Applicable  
polypeptide ENSMUSP00000022501 Ensembl | MGI Sequence Detail 824 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • EC
    4.6.1.2
  • InterPro Domains
    IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
    IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
    IPR011645 Haem NO binding associated
    IPR042463 Haem NO binding associated domain superfamily
    IPR011644 Heme NO-binding
    IPR038158 H-NOX domain superfamily
    IPR024096 NO signalling/Golgi transport ligand-binding domain superfamily
    IPR029787 Nucleotide cyclase
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Phenotypes 7
  • Earliest
    J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
  • Latest
    J:307157 Koike K, et al., Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide. Neuron. 2021 Jun;109:1-16
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/09/2026
MGI 6.24 		The Jackson Laboratory