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Adcy10 Gene Detail
Summary
  • Symbol
    Adcy10
  • Name
    adenylate cyclase 10
  • Synonyms
    4930431D04Rik, sAC, Sacy, soluble adenylyl cyclase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2660854
    NCBI Gene: 271639
  • Gene Overview
    MyGene.info: ADCY10
Location & Maps
more
  • Sequence Map
    Chr1:165485183-165576774 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      91592 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 72.83 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ADCY10, adenylate cyclase 10, soluble
  • Vertebrate Orthologs
    19
  • Human Ortholog
    ADCY10, adenylate cyclase 10, soluble
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HCA2, HEL-S-7a, hsAC, SAC, SACI, Sacy
  • Links
    NCBI Gene ID: 55811
    neXtProt AC: NX_Q96PN6

  • Chr Location
    1q24; chr1:167809080-167915526 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ADCY10 associations

Human Disease Mouse Models
       Hypercalciuria, Absorptive, 2; HCA2   OMIM: 143870
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Targeted
    5
  • Genomic Mutations
    2 involving Adcy10
  • Incidental Mutations
Homozygous null male mutants are infertile with a severe sperm motility defect, female null mutants are fertile. Females exhibit increased cholesterol and triglyceride levels while both sexes have a slight increase in heart rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021452 VEGA Gene Model | MGI Sequence Detail 91592 C57BL/6J ±  kb
transcript OTTMUST00000050855 VEGA | MGI Sequence Detail 5210 Not Applicable  
polypeptide OTTMUSP00000023839 VEGA | MGI Sequence Detail 1614 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    764 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000003752 adenylate cyclase type 10
  • EC
  • InterPro Domains
    IPR016577 Adenylate cylcase, type 10
    IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
    IPR029787 Nucleotide cyclase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR011990 Tetratricopeptide-like helical domain
Molecular
Reagents
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  • All nucleic 16
    cDNA 13
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGI:1859518, MGI:1921027
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:61511 Sinclair ML, et al., Specific expression of soluble adenylyl cyclase in male germ cells. Mol Reprod Dev. 2000 May;56(1):6-11
  • Latest
    J:226345 Watson RL, et al., Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med. 2015 Jun 29;212(7):1021-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory