Adcy10
Gene Detail

Symbol Name ID

Adcy10 adenylate cyclase 10 MGI:2660854

Synonyms

4930431D04Rik, sAC, Sacy, soluble adenylyl cyclase

Feature Type

protein coding gene

Genetic Map

Chromosome 1

72.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:165485183-165576774 bp, + strand From VEGA annotation of GRCm38   91592 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10188  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Protein SuperFamily: soluble adenylyl cyclase
Gene Tree: Adcy10

Human homologs

Human Homolog		ADCY10, adenylate cyclase 10 (soluble)
NCBI Gene ID		55811
neXtProt AC		NX_Q96PN6
Human Synonyms		HCA2, RP1-313L4.2, SAC, SACI, Sacy
Human Chr (Location)		1q24; chr1:167778625-167883453 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ADCY10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Homozygous null male mutants are infertile with a severe sperm motility defect, female null mutants are fertile. Females exhibit increased cholesterol and triglyceride levels while both sexes have a slight increase in heart rate.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	cAMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component	apical part of cell, axon, ...
Function	adenylate cyclase activity, ATPase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (154)    Tissues (126)    Images (11)
Theiler Stages: 16, 17, 18, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	126
Northern blot	6
RT-PCR	22

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000021452 (Evidence)
Ensembl Gene Model	ENSMUSG00000026567 (Evidence)
Entrez Gene	271639 (Evidence)
UniGene	66952
DFCI	TC1590481, TC1673243, TC1732526
DoTS	DT.55124910, DT.60102606, DT.99691709
NIA Mouse Gene Index	U001034
EC	4.6.1.1
Consensus CDS Project	CCDS35756.1
International Mouse Knockout Project Status	Adcy10

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021452	VEGA Gene Model | MGI Sequence Detail	91592	C57BL/6J
transcript	OTTMUST00000050855	VEGA | MGI Sequence Detail	5210	Not Applicable
polypeptide	OTTMUSP00000023839	VEGA | MGI Sequence Detail	1614	Not Applicable

All sequences(40) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(608 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016577	Adenylate cylcase, type 10
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
Protein Ontology	PR:000003752	adenylate cyclase type 10

References

(Earliest) J:61511 Sinclair ML, et al., Specific expression of soluble adenylyl cyclase in male germ cells. Mol Reprod Dev. 2000 May;56(1):6-11
(Latest) J:188405 Choi HB, et al., Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase. Neuron. 2012 Sep 20;75(6):1094-104
All references(48)

Other accession IDs

MGI:1859518, MGI:1921027