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Adcy10 Gene Detail
Summary
  • Symbol
    Adcy10
  • Name
    adenylate cyclase 10
  • Synonyms
    4930431D04Rik, sAC, Sacy, soluble adenylyl cyclase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2660854
    NCBI Gene: 271639
  • Gene Overview
    MyGene.info: ADCY10
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:165485183-165576774 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      91592 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 72.83 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ADCY10, adenylate cyclase 10
  • Vertebrate Orthologs
    19
  • Human Ortholog
    ADCY10, adenylate cyclase 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HCA2, HEL-S-7a, hsAC, SAC, SACI, Sacy
  • Links
    NCBI Gene ID: 55811
    neXtProt AC: NX_Q96PN6
    UniProt: Q96PN6

  • Chr Location
    1q24.2; chr1:167809080-167915556 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null male mutants are infertile with a severe sperm motility defect, female null mutants are fertile. Females exhibit increased cholesterol and triglyceride levels while both sexes have a slight increase in heart rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021452 VEGA Gene Model | MGI Sequence Detail 91592 C57BL/6J ±  kb
    transcript OTTMUST00000050855 VEGA | MGI Sequence Detail 5210 Not Applicable  
    polypeptide OTTMUSP00000023839 VEGA | MGI Sequence Detail 1614 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      764 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1859518, MGI:1921027
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:61511 Sinclair ML, et al., Specific expression of soluble adenylyl cyclase in male germ cells. Mol Reprod Dev. 2000 May;56(1):6-11
    • Latest
      J:257119 Shaw PX, et al., Soluble Adenylyl Cyclase Is Required for Retinal Ganglion Cell and Photoreceptor Differentiation. Invest Ophthalmol Vis Sci. 2016 Sep 1;57(11):5083-5092

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory