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Adcy10
Gene Detail
Symbol

Name
ID
Adcy10
adenylate cyclase 10
MGI:2660854
Synonyms
4930431D04Rik, sAC, Sacy, soluble adenylyl cyclase
Feature Type
protein coding gene
Genetic Map
Chromosome 1
72.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:165485183-165576774 bp, + strand
From VEGA annotation of GRCm38

  91592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10188  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 12 chicken

HCOP human homology predictions: ADCY10
Protein SuperFamily: soluble adenylyl cyclase
Gene Tree: Adcy10

Human
homologs
ADCY10, adenylate cyclase 10 (soluble)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55811
neXtProt AC: NX_Q96PN6

Human Synonyms: HCA2, hsAC, SAC, SACI, Sacy

Human Chr (Location): 1q24; chr1:167809080-167915526 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ADCY10

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null male mutants are infertile with a severe sperm motility defect, female null mutants are fertile. Females exhibit increased cholesterol and triglyceride levels while both sexes have a slight increase in heart rate.
 
Interactions
Adcy10 interacts with 68 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cAMP biosynthetic process, cyclic nucleotide biosynthetic process, ...
Component apical part of cell, axon, ...
Function adenylate cyclase activity, ATPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (154)    Tissues (126)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 126
Northern blot 6
RT-PCR 22
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000021452 (Evidence)
Ensembl Gene Model ENSMUSG00000026567 (Evidence)
Entrez Gene 271639 (Evidence)
UniGene 66952
DFCI TC1732526, TC1673243, TC1590481
DoTS DT.99691709, DT.60102606, DT.55124910
NIA Mouse Gene Index U001034
EC 4.6.1.1
Consensus CDS Project CCDS35756.1
International Mouse Phenotyping Consortium Status Adcy10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021452 VEGA Gene Model | MGI Sequence Detail 91592 C57BL/6J ±  kb
transcript OTTMUST00000050855 VEGA | MGI Sequence Detail 5210 Not Applicable 
polypeptide OTTMUSP00000023839 VEGA | MGI Sequence Detail 1614 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(769 from dbSNP Build 137)    SNPs within 2kb including multiple locations(771)
Protein-related
information
ResourceIDDescription
InterPro IPR016577 Adenylate cylcase, type 10
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003752 adenylate cyclase type 10
References
(Earliest) J:61511 Sinclair ML, et al., Specific expression of soluble adenylyl cyclase in male germ cells. Mol Reprod Dev. 2000 May;56(1):6-11
(Latest) J:204984 Zippin JH, et al., CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor. J Biol Chem. 2013 Nov 15;288(46):33283-91
All references(47)
Other
accession IDs
MGI:1859518, MGI:1921027

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory