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Slc5a6
Gene Detail
 Symbol
Name
ID
Slc5a6
solute carrier family 5 (sodium-dependent vitamin transporter), member 6
MGI:2660847
Feature Type protein coding gene
Genetic Map
Chromosome 5
16.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:31036036-31048924 bp, - strand
From VEGA annotation of GRCm38

  12889 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23277  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Gene Tree: Slc5a6

Human
homologs
Human Homolog SLC5A6, solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
NCBI Gene ID 8884
neXtProt AC  NX_Q9Y289
Human Synonyms  SMVT
Human Chr (Location)  2p23; chr2:27199587-27212307 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Radiation induced(2) Targeted(3)
Genomic Mutations involving Slc5a6 (2)
Incidental mutations (data from Mutagenetix , APF )
Alleles Annotated to Human Diseases(1)   
Interactions
Slc5a6 interacts with 146 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process biotin transport, ion transport, ...
Component brush border membrane, integral component of membrane, ...
Function sodium-dependent multivitamin transmembrane transporter activity, symporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (99)    Tissues (10)    Images (22)
Theiler Stages: 3, 23
Assay TypeResults
RNA in situ 75
RT-PCR 24
cDNA source data(50)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(50) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022376 (Evidence)
Ensembl Gene ModelENSMUSG00000006641 (Evidence)
Entrez Gene330064 (Evidence)
UniGene205463
DFCITC1576302
NIA Mouse Gene IndexU026052, U173239
Consensus CDS ProjectCCDS19169.1
International Mouse Knockout Project StatusSlc5a6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022376 VEGA Gene Model | MGI Sequence Detail 12889 C57BL/6J ±  kb
transcript OTTMUST00000053444 VEGA | MGI Sequence Detail 3248 Not Applicable 
polypeptide OTTMUSP00000025409 VEGA | MGI Sequence Detail 634 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(125 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001734 Sodium/solute symporter
InterPro IPR018212 Sodium/solute symporter, conserved site
InterPro IPR019900 Sodium/solute symporter, subgroup
Protein Ontology PR:000015172 sodium-dependent multivitamin transporter
References (Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:194700 Ghosal A, et al., Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G64-71
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory