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Adamts20 Gene Detail
Summary
  • Symbol
    Adamts20
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
  • Synonyms
    ADAMTS-20, bt
  • Feature Type
    protein coding gene
  • IDs
    MGI:2660628
    NCBI Gene: 223838
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:94268314-94432074 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 48.20 cM
  • Mapping Data
    34 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1355 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2660628
protein coding gene Chr15:94268314-94465418 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022258
protein coding gene Chr15:95730550-95926009 (-)
A/J MGP_AJ_G0022217
protein coding gene Chr15:92004548-92193415 (-)
AKR/J MGP_AKRJ_G0022192
protein coding gene Chr15:94775493-94983882 (-)
BALB/cJ MGP_BALBcJ_G0022223
protein coding gene Chr15:92155357-92351108 (-)
C3H/HeJ MGP_C3HHeJ_G0021993
protein coding gene Chr15:94802993-94995069 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022668
protein coding gene Chr15:99221777-99431452 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020194
protein coding gene Chr15:88042327-88224348 (-)
CAST/EiJ MGP_CASTEiJ_G0021515
protein coding gene Chr15:95609932-95806820 (-)
CBA/J MGP_CBAJ_G0021960
protein coding gene Chr15:102573403-102785233 (-)
DBA/2J MGP_DBA2J_G0022087
protein coding gene Chr15:91457630-91644171 (-)
FVB/NJ MGP_FVBNJ_G0022066
protein coding gene Chr15:90461452-90649735 (-)
LP/J MGP_LPJ_G0022158
protein coding gene Chr15:95852583-96049501 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022086
protein coding gene Chr15:106884732-107087260 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022683
protein coding gene Chr15:94864004-95053845 (-)
PWK/PhJ MGP_PWKPhJ_G0021256
protein coding gene Chr15:91507440-91695831 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021090
protein coding gene Chr15:94603007-94795110 (-)
WSB/EiJ MGP_WSBEiJ_G0021564
protein coding gene Chr15:95368703-95560648 (-)



Homology
more
  • Human Ortholog
    ADAMTS20, ADAM metallopeptidase with thrombospondin type 1 motif 20
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ADAMTS20, ADAM metallopeptidase with thrombospondin type 1 motif 20
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAM-TS20, ADAMTS-20, GON-1
  • Links
    NCBI Gene ID: 80070
    neXtProt AC: NX_P59510
    UniProt: P59510

  • Chr Location
    12q12; chr12:43352843-43551971 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 21 alleles in 22 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for spontaneous or ENU-induced mutations exhibit abnormal coat/hair pigmentation, including a typical white belt phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 223838 NCBI Gene Model | MGI Sequence Detail 163761 C57BL/6J ±  kb
    transcript NM_177431 RefSeq | MGI Sequence Detail 7964 C57BL/6  
    polypeptide P59511 UniProt | EBI | MGI Sequence Detail 1906 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 16
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1678, MGI:88212
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 5
      Phenotypes 49
    • Earliest
      J:283 Murray JM, et al., Belted, a new sixth chromosome mutation in the mouse. J Hered. 1945;36:266-8
    • Latest
      J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory