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Adamts20 Gene Detail
Summary
  • Symbol
    Adamts20
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20
  • Synonyms
    ADAMTS-20, bt
  • Feature Type
    protein coding gene
  • IDs
    MGI:2660628
    NCBI Gene: 223838
Location & Maps
more
  • Sequence Map
    Chr15:94270163-94465418 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      195256 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 48.20 cM
  • Mapping Data
    34 experiments
Homology
more
  • Human Ortholog
    ADAMTS20, ADAM metallopeptidase with thrombospondin type 1 motif 20
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ADAMTS20, ADAM metallopeptidase with thrombospondin type 1 motif 20
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAM-TS20, ADAMTS-20, GON-1
  • Links
    NCBI Gene ID: 80070
    neXtProt AC: NX_P59510

  • Chr Location
    12q12; chr12:43352843-43551940 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 18 alleles in 20 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Chemically induced (ENU)
    8
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Spontaneous
    12
  • Targeted
    1
  • Genomic Mutations
    3 involving Adamts20
  • Incidental Mutations
Mice homozygous for spontaneous or ENU-induced mutations exhibit abnormal coat/hair pigmentation, including a typical white belt phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025504 VEGA Gene Model | MGI Sequence Detail 195256 C57BL/6J ±  kb
transcript OTTMUST00000062776 VEGA | MGI Sequence Detail 6027 Not Applicable  
polypeptide OTTMUSP00000031011 VEGA | MGI Sequence Detail 1906 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1344 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 18
    cDNA 15
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-1678, MGI:88212
References
more
  • Summaries
    All 76
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 5
    Phenotypes 45
  • Earliest
    J:283 Murray JM, et al., Belted, a new sixth chromosome mutation in the mouse. J Hered. 1945;36:266-8
  • Latest
    J:228583 Nandadasa S, et al., ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015 Jun 16;11(10):1519-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory