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Rapgef2
Gene Detail
 Symbol
Name
ID
Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
MGI:2659071
Synonyms 5830453M24Rik, CNRasGEF, mKIAA0313, nRapGEP, Pdzgef1, RA-GEF-1
Feature Type protein coding gene
Genetic Map
Chromosome 3
34.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:79062516-79181340 bp, - strand
From VEGA annotation of GRCm38

  118825 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rapgef2

Human
homologs
Human Homolog RAPGEF2, Rap guanine nucleotide exchange factor (GEF) 2
NCBI Gene ID 9693
neXtProt AC  NX_Q9Y4G8
Human Synonyms  CNrasGEF, nRap GEP, NRAPGEP, PDZGEF1, PDZ-GEF1, RA-GEF, RA-GEF-1, Rap-GEP
Human Chr (Location)  4q32.1; chr4:159104072-159360162 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele die at mid-gestation exhibiting growth arrest and defects in vascular development, neural tube closure and embryo turning. Homozygotes for another null allele show yolk sac vascular defects, impaired cell physiology and heart, primitive gut, liver and brain formation.
 
Interactions
Rapgef2 interacts with 397 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (83 annotations)
Process adenylate cyclase-activating adrenergic receptor signaling pathway, blood vessel development, ...
Component cell junction, cytoplasm, ...
Function beta-1 adrenergic receptor binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (9)    Images (7)
Theiler Stages: 9, 11, 13, 15, 17, 19, 23
Assay TypeResults
Immunohistochemistry 2
RNA in situ 7
Western blot 9
RT-PCR 6
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031912 (Evidence)
Ensembl Gene ModelENSMUSG00000062232 (Evidence)
Entrez Gene76089 (Evidence)
DFCITC1597031, TC1617641
DoTSDT.101131239, DT.101179992, DT.40142867, DT.91401560
NIA Mouse Gene IndexU024168
Consensus CDS ProjectCCDS50932.1
International Mouse Knockout Project StatusRapgef2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031912 VEGA Gene Model | MGI Sequence Detail 118825 C57BL/6J ±  kb
transcript OTTMUST00000079129 VEGA | MGI Sequence Detail 6573 Not Applicable 
polypeptide OTTMUSP00000042162 VEGA | MGI Sequence Detail 1496 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(14) UniProt(4)
Polymorphisms SNPs within 2kb(821 from dbSNP Build 137)    SNPs within 2kb including multiple locations(823)
Protein-related
information
ResourceIDDescription
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR001478 PDZ domain
InterPro IPR000159 Ras-association
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000013727 rap guanine nucleotide exchange factor 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201420 Emery AC, et al., Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells. Sci Signal. 2013 Jun 25;6(281):ra51
All references(41)
Other
accession IDs
MGI:1923339

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory