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Rapgef2
Gene Detail
Symbol

Name
ID
Rapgef2
Rap guanine nucleotide exchange factor (GEF) 2
MGI:2659071
Synonyms
5830453M24Rik, CNRasGEF, mKIAA0313, nRapGEP, Pdzgef1, RA-GEF-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
34.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:79062516-79286517 bp, - strand
From VEGA annotation of GRCm38

  224002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rapgef2

Human
homologs
Human Homolog   RAPGEF2, Rap guanine nucleotide exchange factor (GEF) 2
NCBI Gene ID 9693
neXtProt AC  NX_Q9Y4G8
Human Synonyms  CNrasGEF, nRap GEP, NRAPGEP, PDZGEF1, PDZ-GEF1, RA-GEF, RA-GEF-1, Rap-GEP
Human Chr (Location)  4q32.1; chr4:159104071-159360162 (+)  GRCh38.p2
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(12) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele die at mid-gestation exhibiting growth arrest and defects in vascular development, neural tube closure and embryo turning. Homozygotes for another null allele show yolk sac vascular defects, impaired cell physiology and heart, primitive gut, liver and brain formation.
 
Interactions
Rapgef2 interacts with 396 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (24)    Tissues (9)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 7
Western blot 9
RT-PCR 6
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031912 (Evidence)
Ensembl Gene ModelENSMUSG00000062232 (Evidence)
Entrez Gene76089 (Evidence)
DFCITC1617641, TC1597031
DoTSDT.40142867, DT.101179992, DT.101131239, DT.91401560
NIA Mouse Gene IndexU024168
Consensus CDS ProjectCCDS50932.1
International Mouse Knockout Project StatusRapgef2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031912 VEGA Gene Model | MGI Sequence Detail 224002 C57BL/6J ±  kb
transcript OTTMUST00000131132 VEGA | MGI Sequence Detail 6964 Not Applicable 
polypeptide OTTMUSP00000070181 VEGA | MGI Sequence Detail 1644 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(14) UniProt(5)
Polymorphisms
SNPs within 2kb(1903 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1905)
Protein-related
information
ResourceIDDescription
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR001895 Guanine-nucleotide dissociation stimulator CDC25
InterPro IPR001478 PDZ domain
InterPro IPR000159 Ras-association
InterPro IPR023578 Ras guanine nucleotide exchange factor, domain
InterPro IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000013727 rap guanine nucleotide exchange factor 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:217266 Monteiro AC, et al., JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function. Mol Biol Cell. 2013 Sep;24(18):2849-60
All references(44)
Other
accession IDs
MGI:1923339

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory