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Phactr1
Gene Detail
Symbol

Name
ID
Phactr1
phosphatase and actin regulator 1
MGI:2659021
Synonyms
9630030F18Rik, Rpel1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
21.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:42680623-43138526 bp, + strand
From VEGA annotation of GRCm38

  457904 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:33597  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PHACTR1
Protein SuperFamily: phosphatase and actin regulator
Gene Tree: Phactr1

Human
homologs
PHACTR1, phosphatase and actin regulator 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 221692
neXtProt AC: NX_Q9C0D0

Human Synonyms: dJ257A7.2, RPEL, RPEL1

Human Chr (Location): 6p24.1; chr6:12716606-13290244 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Phactr1 interacts with 341 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process actin cytoskeleton reorganization, actomyosin structure organization, ...
Component cell junction, cytoplasm, ...
Function actin binding, protein phosphatase 1 binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (14)    Tissues (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 14
cDNA source data(59)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA PHACTR1 ; Xenbase phactr1    NEW 
Molecular
reagents
All nucleic(61) cDNA(61)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000023876 (Evidence)
Ensembl Gene Model ENSMUSG00000054728 (Evidence)
Entrez Gene 218194 (Evidence)
UniGene 160124
DFCI TC1619121, TC1601923, TC1594867, TC1583529, TC1712975, TC1627880, TC1590310
DoTS DT.101378760, DT.101734446, DT.91334168, DT.91392984, DT.103571463, DT.40164331, DT.91394901, DT.94126265, DT.94175185
PDB 4B1U, 4B1Z, 4B1Y, 4B1W, 4B1V, 4B1X
Consensus CDS Project CCDS26475.1, CCDS49251.1
International Mouse Phenotyping Consortium Status Phactr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023876 VEGA Gene Model | MGI Sequence Detail 457904 C57BL/6J ±  kb
transcript OTTMUST00000065150 VEGA | MGI Sequence Detail 5307 Not Applicable 
polypeptide OTTMUSP00000032430 VEGA | MGI Sequence Detail 642 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(19) UniProt(4)
Polymorphisms
SNPs within 2kb(3297 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004018 RPEL repeat
Protein Ontology PR:000012626 phosphatase and actin regulator 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:196227 Wiezlak M, et al., G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly. J Cell Sci. 2012 Dec 1;125(Pt 23):5860-72
All references(34)
Other
accession IDs
MGI:1925996

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory