About   Help   FAQ
Wasf3
Gene Detail
Symbol

Name
ID
Wasf3
WAS protein family, member 3
MGI:2658986
Synonyms
Wave3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
85.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:146384985-146435471 bp, + strand
From VEGA annotation of GRCm38

  50487 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68527  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Wiskott-Aldrich syndrome protein
Gene Tree: Wasf3

Human
homologs
Human Homolog WASF3, WAS protein family, member 3
NCBI Gene ID 10810
neXtProt AC  NX_Q9UPY6
Human Synonyms  Brush-1, SCAR3, WAVE3
Human Chr (Location)  13q12; chr13:26557703-26688945 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(49) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal platelet physiology.
 
Interactions
Wasf3 interacts with 252 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process actin cytoskeleton organization, cytoskeleton organization, ...
Component cytoplasm, cytoskeleton, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (190)    Tissues (33)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 177
RT-PCR 12
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000025851 (Evidence)
Ensembl Gene ModelENSMUSG00000029636 (Evidence)
Entrez Gene245880 (Evidence)
UniGene472750
DFCITC1633033, TC1583510
DoTSDT.55281562
NIA Mouse Gene IndexU142611
Consensus CDS ProjectCCDS19870.1
International Mouse Knockout Project StatusWasf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025851 VEGA Gene Model | MGI Sequence Detail 50487 C57BL/6J ±  kb
transcript OTTMUST00000063689 VEGA | MGI Sequence Detail 589 Not Applicable 
polypeptide OTTMUSP00000031528 VEGA | MGI Sequence Detail 45 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(395 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003124 WH2 domain
Protein Ontology PR:000017374 Wiskott-Aldrich syndrome protein family member 3
References
(Earliest) J:83138 Sossey-Alaoui K, et al., Genomic organization and expression profile of the human and mouse WAVE gene family. Mamm Genome. 2003 May;14(5):314-22
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory