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Wasf3
Gene Detail
Symbol

Name
ID
Wasf3
WAS protein family, member 3
MGI:2658986
Synonyms
Wave3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
85.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:146384985-146435471 bp, + strand
From VEGA annotation of GRCm38

  50487 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68527  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WASF3
Protein SuperFamily: Wiskott-Aldrich syndrome protein
Gene Tree: Wasf3

Human
homologs
WASF3, WAS protein family, member 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10810
neXtProt AC: NX_Q9UPY6

Human Synonyms: Brush-1, SCAR3, WAVE3

Human Chr (Location): 13q12; chr13:26557703-26688945 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(49) Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit normal platelet physiology.
 
Interactions
Wasf3 interacts with 251 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process actin cytoskeleton organization, cytoskeleton organization, ...
Component cytoplasm, cytoskeleton, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (190)    Tissues (33)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 177
RT-PCR 12
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase wasf3    NEW 
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000025851 (Evidence)
Ensembl Gene Model ENSMUSG00000029636 (Evidence)
Entrez Gene 245880 (Evidence)
UniGene 472750
DFCI TC1583510, TC1633033
DoTS DT.55281562
NIA Mouse Gene Index U142611
Consensus CDS Project CCDS19870.1
International Mouse Phenotyping Consortium Status Wasf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025851 VEGA Gene Model | MGI Sequence Detail 50487 C57BL/6J ±  kb
transcript OTTMUST00000063689 VEGA | MGI Sequence Detail 589 Not Applicable 
polypeptide OTTMUSP00000031528 VEGA | MGI Sequence Detail 45 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(395 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003124 WH2 domain
Protein Ontology PR:000017374 Wiskott-Aldrich syndrome protein family member 3
References
(Earliest) J:83138 Sossey-Alaoui K, et al., Genomic organization and expression profile of the human and mouse WAVE gene family. Mamm Genome. 2003 May;14(5):314-22
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory