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Btla Gene Detail
Summary
  • Symbol
    Btla
  • Name
    B and T lymphocyte associated
  • Feature Type
    protein coding gene
  • IDs
    MGI:2658978
    NCBI Gene: 208154
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:45043121-45073258 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 29.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    509 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2658978
protein coding gene Chr16:45043121-45078033 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022850
protein coding gene Chr16:44001705-44032838 (+)
A/J MGP_AJ_G0022815
protein coding gene Chr16:42027017-42055156 (+)
AKR/J MGP_AKRJ_G0022787
protein coding gene Chr16:43410429-43439610 (+)
BALB/cJ MGP_BALBcJ_G0022816
protein coding gene Chr16:42033879-42063650 (+)
C3H/HeJ MGP_C3HHeJ_G0022580
protein coding gene Chr16:43562339-43588770 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023263
protein coding gene Chr16:44992988-45023506 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020777
protein coding gene Chr16:42420822-42448876 (+)
CAST/EiJ MGP_CASTEiJ_G0022105
protein coding gene Chr16:43748645-43777422 (+)
CBA/J MGP_CBAJ_G0022551
protein coding gene Chr16:46899133-46928516 (+)
DBA/2J MGP_DBA2J_G0022683
protein coding gene Chr16:41770491-41797668 (+)
FVB/NJ MGP_FVBNJ_G0022659
protein coding gene Chr16:41692412-41719060 (+)
LP/J MGP_LPJ_G0022751
protein coding gene Chr16:43736192-43763634 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022677
protein coding gene Chr16:46307743-46336372 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023278
protein coding gene Chr16:43426425-43454141 (+)
PWK/PhJ MGP_PWKPhJ_G0021845
protein coding gene Chr16:42133553-42162419 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021676
protein coding gene Chr16:43349356-43380712 (+)
WSB/EiJ MGP_WSBEiJ_G0022150
protein coding gene Chr16:43516936-43546104 (+)



Homology
more
  • Human Ortholog
    BTLA, B and T lymphocyte associated
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BTLA, B and T lymphocyte associated
  • Synonyms
    BTLA1, CD272
  • Links
    NCBI Gene ID: 151888
    neXtProt AC: NX_Q7Z6A9
    UniProt: Q7Z6A9

  • Chr Location
    3q13.2; chr3:112463966-112499624 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene leads to increased T cell activation. Homozygotes for a null allele show altered peripheral T cell anergy. Homozygotes for a different null allele show enhanced specific antibody responses, increased susceptibility to EAE, and prolonged allograft survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 208154 NCBI Gene Model | MGI Sequence Detail 30138 C57BL/6J ±  kb
transcript NM_001037719 RefSeq | MGI Sequence Detail 3235 C57BL/6  
polypeptide Q7TSA3 UniProt | EBI | MGI Sequence Detail 306 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 33
    cDNA 32
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 68
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 36
  • Earliest
    J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
  • Latest
    J:337669 Seo GY, et al., Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection. Sci Immunol. 2022 Jul 29;7(73):eabm6931

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory