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Btla Gene Detail
Summary
  • Symbol
    Btla
  • Name
    B and T lymphocyte associated
  • Feature Type
    protein coding gene
  • IDs
    MGI:2658978
    NCBI Gene: 208154
  • Gene Overview
    MyGene.info: BTLA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:45224315-45252892 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28578 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 29.52 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BTLA, B and T lymphocyte associated
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BTLA, B and T lymphocyte associated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTLA1, CD272
  • Links
    NCBI Gene ID: 151888
    neXtProt AC: NX_Q7Z6A9
    UniProt: Q7Z6A9

  • Chr Location
    3q13.2; chr3:112458790-112499756 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene leads to increased T cell activation. Homozygotes for a null allele show altered peripheral T cell anergy. Homozygotes for a different null allele show enhanced specific antibody responses, increased susceptibility to EAE, and prolonged allograft survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014972 VEGA Gene Model | MGI Sequence Detail 28578 C57BL/6J ±  kb
transcript OTTMUST00000035544 VEGA | MGI Sequence Detail 3251 Not Applicable  
polypeptide OTTMUSP00000015921 VEGA | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    495 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    cDNA 32

    Microarray probesets 3
References
more
  • Summaries
    All 56
    Gene Ontology 4
    Phenotypes 27
  • Earliest
    J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
  • Latest
    J:264695 Jones A, et al., Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells. Immunity. 2016 Nov 15;45(5):1066-1077

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory