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Btla Gene Detail
Summary
  • Symbol
    Btla
  • Name
    B and T lymphocyte associated
  • Feature Type
    protein coding gene
  • IDs
    MGI:2658978
    NCBI Gene: 208154
  • Gene Overview
    MyGene.info: BTLA
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:45223545-45252895 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 29.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    495 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2658978
protein coding gene Chr16:45223545-45257670 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022850
protein coding gene Chr16:44001705-44032838 (+)
A/J MGP_AJ_G0022815
protein coding gene Chr16:42027017-42055156 (+)
AKR/J MGP_AKRJ_G0022787
protein coding gene Chr16:43410429-43439610 (+)
BALB/cJ MGP_BALBcJ_G0022816
protein coding gene Chr16:42033879-42063650 (+)
C3H/HeJ MGP_C3HHeJ_G0022580
protein coding gene Chr16:43562339-43588770 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023263
protein coding gene Chr16:44992988-45023506 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020777
protein coding gene Chr16:42420822-42448876 (+)
CAST/EiJ MGP_CASTEiJ_G0022105
protein coding gene Chr16:43748645-43777422 (+)
CBA/J MGP_CBAJ_G0022551
protein coding gene Chr16:46899133-46928516 (+)
DBA/2J MGP_DBA2J_G0022683
protein coding gene Chr16:41770491-41797668 (+)
FVB/NJ MGP_FVBNJ_G0022659
protein coding gene Chr16:41692412-41719060 (+)
LP/J MGP_LPJ_G0022751
protein coding gene Chr16:43736192-43763634 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022677
protein coding gene Chr16:46307743-46336372 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023278
protein coding gene Chr16:43426425-43454141 (+)
PWK/PhJ MGP_PWKPhJ_G0021845
protein coding gene Chr16:42133553-42162419 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021676
protein coding gene Chr16:43349356-43380712 (+)
WSB/EiJ MGP_WSBEiJ_G0022150
protein coding gene Chr16:43516936-43546104 (+)



Homology
more
  • Human Ortholog
    BTLA, B and T lymphocyte associated
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BTLA, B and T lymphocyte associated
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BTLA1, CD272
  • Links
    NCBI Gene ID: 151888
    neXtProt AC: NX_Q7Z6A9
    UniProt: Q7Z6A9

  • Chr Location
    3q13.2; chr3:112458790-112499756 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene leads to increased T cell activation. Homozygotes for a null allele show altered peripheral T cell anergy. Homozygotes for a different null allele show enhanced specific antibody responses, increased susceptibility to EAE, and prolonged allograft survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 208154 NCBI Gene Model | MGI Sequence Detail 29351 C57BL/6J ±  kb
transcript NM_001037719 RefSeq | MGI Sequence Detail 3235 C57BL/6  
polypeptide Q7TSA3 UniProt | EBI | MGI Sequence Detail 306 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 32
    cDNA 32

    Microarray probesets 3
References
more
  • Summaries
    All 55
    Gene Ontology 4
    Phenotypes 27
  • Earliest
    J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
  • Latest
    J:264695 Jones A, et al., Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells. Immunity. 2016 Nov 15;45(5):1066-1077

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory