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Btla Gene Detail
Summary
  • Symbol
    Btla
  • Name
    B and T lymphocyte associated
  • Feature Type
    protein coding gene
  • IDs
    MGI:2658978
    NCBI Gene: 208154
  • Gene Overview
    MyGene.info: BTLA
Location & Maps
more
  • Sequence Map
    Chr16:45224315-45252892 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28578 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 29.52 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BTLA, B and T lymphocyte associated
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BTLA, B and T lymphocyte associated
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BTLA1, CD272
  • Links
    NCBI Gene ID: 151888
    neXtProt AC: NX_Q7Z6A9

  • Chr Location
    3q13.2; chr3:112463966-112499702 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Incidental Mutations
    APF
Targeted inactivation of this gene leads to increased T cell activation. Homozygotes for a null allele show altered peripheral T cell anergy. Homozygotes for a different null allele show enhanced specific antibody responses, increased susceptibility to EAE, and prolonged allograft survival.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014972 VEGA Gene Model | MGI Sequence Detail 28578 C57BL/6J ±  kb
transcript OTTMUST00000035544 VEGA | MGI Sequence Detail 3251 Not Applicable  
polypeptide OTTMUSP00000015921 VEGA | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    495 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 31

    Microarray probesets 3
References
more
  • Summaries
    All 52
    Gene Ontology 4
    Phenotypes 26
  • Earliest
    J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
  • Latest
    J:209240 Steinberg MW, et al., BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection. PLoS One. 2013;8(10):e77992

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory