Btla
Gene Detail

Symbol Name ID

Btla B and T lymphocyte associated MGI:2658978

Feature Type

protein coding gene

Genetic Map

Chromosome 16

29.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:45224315-45252892 bp, + strand From VEGA annotation of GRCm38   28578 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:52233  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: B- and T-lymphocyte attenuator
Gene Tree: Btla

Human homologs

Human Homolog		BTLA, B and T lymphocyte associated
NCBI Gene ID		151888
neXtProt AC		NX_Q7Z6A9
Human Synonyms		BTLA1, CD272
Human Chr (Location)		3q13.2; chr3:112182813-112218408 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Targeted inactivation of this gene leads to increased T cell activation. Homozygotes for a null allele show altered peripheral T cell anergy. Homozygotes for a different null allele show enhanced specific antibody responses, increased susceptibility to EAE, and prolonged allograft survival.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cell surface receptor signaling pathway, immune response-regulating cell surface receptor signaling pathway, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	protein binding, receptor activity

External Resources: FuncBase

Expression

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(31)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000014972 (Evidence)
Ensembl Gene Model	ENSMUSG00000052013 (Evidence)
Entrez Gene	208154 (Evidence)
UniGene	38199
DFCI	TC1583105
DoTS	DT.531033
NIA Mouse Gene Index	U017174
PDB	1XAU
Consensus CDS Project	CCDS28195.1, CCDS28196.1
International Mouse Knockout Project Status	Btla

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014972	VEGA Gene Model | MGI Sequence Detail	28578	C57BL/6J
transcript	OTTMUST00000035544	VEGA | MGI Sequence Detail	3251	Not Applicable
polypeptide	OTTMUSP00000015921	VEGA | MGI Sequence Detail	305	Not Applicable

All sequences(28) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(280 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
Protein Ontology	PR:000001284	B- and T-lymphocyte attenuator

References

(Earliest) J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
(Latest) J:188689 del Rio ML, et al., Selective blockade of herpesvirus entry mediator-B and T lymphocyte attenuator pathway ameliorates acute graft-versus-host reaction. J Immunol. 2012 May 15;188(10):4885-96
All references(51)