About   Help   FAQ
Btla
Gene Detail
 Symbol
Name
ID
Btla
B and T lymphocyte associated
MGI:2658978
Feature Type protein coding gene
Genetic Map
Chromosome 16
29.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:45224315-45252892 bp, + strand
From VEGA annotation of GRCm38

  28578 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:52233  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: B- and T-lymphocyte attenuator
Gene Tree: Btla

Human
homologs
Human Homolog BTLA, B and T lymphocyte associated
NCBI Gene ID 151888
neXtProt AC  NX_Q7Z6A9
Human Synonyms  BTLA1, CD272
Human Chr (Location)  3q13.2; chr3:112463966-112499590 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Targeted inactivation of this gene leads to increased T cell activation. Homozygotes for a null allele show altered peripheral T cell anergy. Homozygotes for a different null allele show enhanced specific antibody responses, increased susceptibility to EAE, and prolonged allograft survival.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell surface receptor signaling pathway, immune response-regulating cell surface receptor signaling pathway, ...
Component external side of plasma membrane, integral component of membrane, ...
Function protein binding, receptor activity
External Resources: FuncBase
Expression
cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(31) cDNA(31)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000014972 (Evidence)
Ensembl Gene ModelENSMUSG00000052013 (Evidence)
Entrez Gene208154 (Evidence)
UniGene38199
DFCITC1583105
DoTSDT.531033
NIA Mouse Gene IndexU017174
PDB1XAU
Consensus CDS ProjectCCDS28195.1, CCDS28196.1
International Mouse Knockout Project StatusBtla
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014972 VEGA Gene Model | MGI Sequence Detail 28578 C57BL/6J ±  kb
transcript OTTMUST00000035544 VEGA | MGI Sequence Detail 3251 Not Applicable 
polypeptide OTTMUSP00000015921 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(10) UniProt(4)
Polymorphisms SNPs within 2kb(495 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001284 B- and T-lymphocyte attenuator
References (Earliest) J:84084 Watanabe N, et al., BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat Immunol. 2003 Jul;4(7):670-9
(Latest) J:209240 Steinberg MW, et al., BTLA interaction with HVEM expressed on CD8(+) T cells promotes survival and memory generation in response to a bacterial infection. PLoS One. 2013;8(10):e77992
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory