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Rtl1 Gene Detail
Summary
  • Symbol
    Rtl1
  • Name
    retrotransposon Gaglike 1
  • Synonyms
    Mar, Mart1, Mor1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2656842
    NCBI Gene: 353326
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
  • Regulated by
    Rr198, Rr199, Igdmr ... (4 regulatory regions)
Location &
Maps
more
  • Sequence Map
    Chr12:109555627-109566764 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.38 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2656842
 protein coding gene Chr12:109531141-109570852 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020115
 protein coding gene Chr12:111817787-111830332 (-)
A/J MGP_AJ_G0020069
 protein coding gene Chr12:107512359-107523141 (-)
AKR/J MGP_AKRJ_G0020045
 protein coding gene Chr12:110649313-110660461 (-)
BALB/cJ MGP_BALBcJ_G0020055
 protein coding gene Chr12:107985757-107996648 (-)
C3H/HeJ MGP_C3HHeJ_G0019857
 protein coding gene Chr12:111090725-111102965 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020500
 protein coding gene Chr12:115237378-115248421 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018112
 protein coding gene Chr12:104038554-104050132 (-)
CAST/EiJ MGP_CASTEiJ_G0019399
 protein coding gene Chr12:106042228-106053111 (-)
CBA/J MGP_CBAJ_G0019824
 protein coding gene Chr12:119776793-119787701 (-)
DBA/2J MGP_DBA2J_G0019941
 protein coding gene Chr12:107067353-107078217 (-)
FVB/NJ MGP_FVBNJ_G0019926
 protein coding gene Chr12:105858017-105868928 (-)
LP/J MGP_LPJ_G0020016
 protein coding gene Chr12:111644957-111658942 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019964
 protein coding gene Chr12:122930849-122945010 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020529
 protein coding gene Chr12:110129192-110142037 (-)
PWK/PhJ MGP_PWKPhJ_G0019158
 protein coding gene Chr12:101675613-101686866 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018962
 protein coding gene Chr12:104299936-104311901 (-)
WSB/EiJ MGP_WSBEiJ_G0019456
 protein coding gene Chr12:111044022-111056107 (-)



Homology
more
  • Human Ortholog
    RTL1, retrotransposon Gag like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTL1, retrotransposon Gag like 1
  • Synonyms
    HUR1, Mar1, MART1, PEG11, SIRH2
  • Links
    NCBI Gene ID: 388015
    UniProt: A6NKG5

  • Chr Location
    14q32.2-q32.31; chr14:100879753-100903722 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a paternally inherited knock-out allele exhibit fetal/neonatal lethality associated with underdevelopment of the placenta. Mice heteroygous for a maternally inherited knock-out allele exhibit neonatal lethality and decreased survival associated with placental overdevelopment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1265
  • Tissues
    139
  • cDNA Data
    7
  • Literature Summary
    30
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000085925 Ensembl Gene Model | MGI Sequence Detail 11138 C57BL/6J ±  kb
    transcript ENSMUST00000149046 Ensembl | MGI Sequence Detail 6358 Not Applicable  
    polypeptide ENSMUSP00000115957 Ensembl | MGI Sequence Detail 1744 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000014344 retrotransposon-like protein 1
      (term hierarchy)
    • InterPro Domains
      IPR021109 Aspartic peptidase domain superfamily
      IPR043502 DNA/RNA polymerase superfamily
      IPR032549 Domain of unknown function DUF4939
      IPR032567 LDOC1-related
      IPR043128 Reverse transcriptase/Diguanylate cyclase domain
      IPR041577 Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 7
      Primer pair 17
      Other 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 30
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:84074 Seitz H, et al., Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene. Nat Genet. 2003 Jul;34(3):261-2
    • Latest
      J:360327 Yu H, et al., Silencing of maternally expressed RNAs in Dlk1-Dio3 domain causes fatal vascular injury in the fetal liver. Cell Mol Life Sci. 2024 Oct 9;81(1):429
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory