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Shc4
Gene Detail
 Symbol
Name
ID
Shc4
SHC (Src homology 2 domain containing) family, member 4
MGI:2655364
Synonyms 6230417E10Rik, 9930029B02Rik, LOC271849
Feature Type protein coding gene
Genetic Map
Chromosome 2
61.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:125627447-125724148 bp, - strand
From VEGA annotation of GRCm38

  96702 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19567  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: SHC-transforming protein
Gene Tree: Shc4

Human
homologs
Human Homolog SHC4, SHC (Src homology 2 domain containing) family, member 4
NCBI Gene ID 399694
neXtProt AC  NX_Q6S5L8
Human Synonyms  RaLP, SHCD
Human Chr (Location)  15q21.1-q21.2; chr15:48823737-48963507 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Shc4 interacts with 268 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process apoptotic process, intracellular signal transduction, ...
Component cell junction, membrane, ...
Function protein domain specific binding, receptor tyrosine kinase binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (195)    Tissues (154)    Images (42)
Theiler Stages: 6, 7, 9, 11, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 122
RNA in situ 63
RT-PCR 10
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(5) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000015349 (Evidence)
Ensembl Gene ModelENSMUSG00000035109 (Evidence)
Entrez Gene271849 (Evidence)
DFCITC1589754, TC1596334, TC1602549
NIA Mouse Gene IndexU023294
Consensus CDS ProjectCCDS16678.1
International Mouse Knockout Project StatusShc4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015349 VEGA Gene Model | MGI Sequence Detail 96702 C57BL/6J ±  kb
transcript OTTMUST00000036375 VEGA | MGI Sequence Detail 4059 Not Applicable 
polypeptide OTTMUSP00000016352 VEGA | MGI Sequence Detail 626 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(884 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR006019 Phosphotyrosine interaction (PID/PI)
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000980 SH2 domain
Protein Ontology PR:000003179 SHC-transforming protein 4
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:194646 Turco MY, et al., Cellular heterogeneity during embryonic stem cell differentiation to epiblast stem cells is revealed by the ShcD/RaLP adaptor protein. Stem Cells. 2012 Nov;30(11):2423-36
All references(29)
Other
accession IDs
MGI:2685531

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory