About   Help   FAQ
Defb8 Gene Detail
Summary
  • Symbol
    Defb8
  • Name
    defensin beta 8
  • Synonyms
    Defr1, mBD8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2654206
    NCBI Gene: 244334
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr8:19445769-19447606 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 10.35 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2654206
protein coding gene Chr8:19445769-19447606 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033420
protein coding gene Chr8:16986925-16987137 (-)
A/J MGP_AJ_G0033401
protein coding gene Chr8:16436592-16436804 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0033401
protein coding gene Chr8:16524952-16525164 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0033915
protein coding gene Chr8:17469670-17471507 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032436
protein coding gene Chr8:16958931-16959143 (-)
CBA/J MGP_CBAJ_G0033087
protein coding gene Chr8:18382233-18382445 (-)
DBA/2J MGP_DBA2J_G0033241
protein coding gene Chr8:16323588-16323800 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0033226
protein coding gene Chr8:18499512-18499724 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033932
protein coding gene Chr8:16887568-16889405 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032553
protein coding gene Chr8:16955265-16955480 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 244334 NCBI Gene Model | MGI Sequence Detail 1838 C57BL/6J ±  kb
transcript NM_153108 RefSeq | MGI Sequence Detail 287 Not Specified  
polypeptide Q91V82 UniProt | EBI | MGI Sequence Detail 60 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2179199
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:78153 Morrison GM, et al., Identification and characterization of a novel murine beta-defensin-related gene. Mamm Genome. 2002 Aug;13(8):445-51
  • Latest
    J:266021 Foronda M, et al., Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation. Cell Rep. 2014 Jul 24;8(2):487-500

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/05/2021
MGI 6.16
The Jackson Laboratory