Defb8
Gene Detail

Symbol Name ID

Defb8 defensin beta 8 MGI:2654206

Synonyms

Defr1, mBD8

Feature Type

protein coding gene

Genetic Map

Chromosome 8

10.35 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:19445769-19447606 bp, - strand From VEGA annotation of GRCm38   1838 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Protein SuperFamily: crotamine
Gene Tree: Defb8

Alleles and phenotypes

All alleles(6) : Gene trapped(6)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	defense response, defense response to bacterium
Component	extracellular region

External Resources: FuncBase

Expression

cDNA source data(1)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(2) cDNA(1) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000020716 (Evidence)
Ensembl Gene Model	ENSMUSG00000031471 (Evidence)
Entrez Gene	244334 (Evidence)
DFCI	TC1594155, TC1630925
DoTS	DT.55113549, DT.91569778
NIA Mouse Gene Index	U053988, U116926
PDB	1E4R
Consensus CDS Project	CCDS40259.1
International Mouse Knockout Project Status	Defb8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020716	VEGA Gene Model | MGI Sequence Detail	1838	C57BL/6J
transcript	OTTMUST00000049031	VEGA | MGI Sequence Detail	287	Not Applicable
polypeptide	OTTMUSP00000022638	VEGA | MGI Sequence Detail	60	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001855	Beta defensin type
Protein Ontology	PR:000006822	beta-defensin 8

References

(Earliest) J:78153 Morrison GM, et al., Identification and characterization of a novel murine beta-defensin-related gene. Mamm Genome. 2002 Aug;13(8):445-51
(Latest) J:148089 Taylor K, et al., Defensin-related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4+ T cells independently of CCR6. Eur J Immunol. 2009 May;39(5):1353-60
All references(24)

Other accession IDs

MGI:2179199