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Defb8
Gene Detail
Symbol

Name
ID
Defb8
defensin beta 8
MGI:2654206
Synonyms
Defr1, mBD8
Feature Type
protein coding gene
Genetic Map
Chromosome 8
10.35 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:19445769-19447606 bp, - strand
From VEGA annotation of GRCm38

  1838 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Protein SuperFamily: crotamine
Gene Tree: Defb8
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(6)
Incidental mutations (data from Mutagenetix )
Interactions
Defb8 interacts with 28 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process defense response, defense response to bacterium
Component extracellular region
External Resources: FuncBase
Expression
cDNA source data(1)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(1) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020716 (Evidence)
Ensembl Gene ModelENSMUSG00000031471 (Evidence)
Entrez Gene244334 (Evidence)
DFCITC1594155, TC1630925
DoTSDT.91569778, DT.55113549
NIA Mouse Gene IndexU053988, U116926
PDB1E4R
Consensus CDS ProjectCCDS40259.1
International Mouse Knockout Project StatusDefb8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020716 VEGA Gene Model | MGI Sequence Detail 1838 C57BL/6J ±  kb
transcript OTTMUST00000049031 VEGA | MGI Sequence Detail 287 Not Applicable 
polypeptide OTTMUSP00000022638 VEGA | MGI Sequence Detail 60 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(75 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001855 Beta defensin type
Protein Ontology PR:000006822 beta-defensin 8
References
(Earliest) J:78153 Morrison GM, et al., Identification and characterization of a novel murine beta-defensin-related gene. Mamm Genome. 2002 Aug;13(8):445-51
(Latest) J:148089 Taylor K, et al., Defensin-related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4+ T cells independently of CCR6. Eur J Immunol. 2009 May;39(5):1353-60
All references(24)
Other
accession IDs
MGI:2179199

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory