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Sox21
Gene Detail
Symbol

Name
ID
Sox21
SRY (sex determining region Y)-box 21
MGI:2654070
Synonyms
Sox25
Feature Type
protein coding gene
Genetic Map
Chromosome 14
61.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:118233232-118237030 bp, - strand
From VEGA annotation of GRCm38

  3799 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5143  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 western clawed frog; 1 zebrafish

Gene Tree: Sox21

Human
homologs
Human Homolog SOX21, SRY (sex determining region Y)-box 21
NCBI Gene ID 11166
neXtProt AC  NX_Q9Y651
Human Synonyms  SOX25
Human Chr (Location)  13q31-q32; chr13:94709622-94712135 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display cyclic alopecia, epidermal hyperplasia, enlarged sebaceous glands, and hair shaft and cuticle abnormalities.
 
Interactions
Sox21 interacts with 265 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process hair cycle, hair follicle development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding transcription factor activity
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (96)    Tissues (65)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 48
In situ reporter (knock in) 15
RT-PCR 16
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036706 (Evidence)
Ensembl Gene ModelENSMUSG00000061517 (Evidence)
Entrez Gene223227 (Evidence)
UniGene70950
DFCITC1703097, TC1623939, TC1582205
DoTSDT.91328241, DT.99853170, DT.94239610
NIA Mouse Gene IndexU015966
Consensus CDS ProjectCCDS27334.1
International Mouse Knockout Project StatusSox21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036706 VEGA Gene Model | MGI Sequence Detail 3799 C57BL/6J ±  kb
transcript OTTMUST00000094042 VEGA | MGI Sequence Detail 3799 Not Applicable 
polypeptide OTTMUSP00000052241 VEGA | MGI Sequence Detail 276 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR022097 Transcription factor SOX
Protein Ontology PR:000015427 transcription factor SOX-21
References
(Earliest) J:81702 Hwang CK, et al., Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins. J Biol Chem. 2003 Feb 7;278(6):3742-50
(Latest) J:197716 Ng CK, et al., Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res. 2012 Jun;40(11):4933-41
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory