Sox21
Gene Detail

Symbol Name ID

Sox21 SRY-box containing gene 21 MGI:2654070

Synonyms

Sox25

Feature Type

protein coding gene

Genetic Map

Chromosome 14

61.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:118233232-118237030 bp, - strand From VEGA annotation of GRCm38   3799 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5143  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 zebrafish

Gene Tree: Sox21

Human homologs

Human Homolog		SOX21, SRY (sex determining region Y)-box 21
NCBI Gene ID		11166
neXtProt AC		NX_Q9Y651
Human Synonyms		SOX25
Human Chr (Location)		13q31-q32; chr13:95361876-95364389 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a null mutation display cyclic alopecia, epidermal hyperplasia, enlarged sebaceous glands, and hair shaft and cuticle abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	hair cycle, hair follicle development, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding transcription factor activity

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (103)    Tissues (69)    Images (52)
Theiler Stages: 2, 3, 4, 5, 17, 18, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	17
RNA in situ	48
In situ reporter (knock in)	15
RT-PCR	23

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(1) cDNA(18) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000036706 (Evidence)
Ensembl Gene Model	ENSMUSG00000061517 (Evidence)
Entrez Gene	223227 (Evidence)
UniGene	70950
DFCI	TC1582205, TC1623939, TC1703097
DoTS	DT.91328241, DT.94239610, DT.99853170
NIA Mouse Gene Index	U015966
Consensus CDS Project	CCDS27334.1
International Mouse Knockout Project Status	Sox21

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036706	VEGA Gene Model | MGI Sequence Detail	3799	C57BL/6J
transcript	OTTMUST00000094042	VEGA | MGI Sequence Detail	3799	Not Applicable
polypeptide	OTTMUSP00000052241	VEGA | MGI Sequence Detail	276	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Protein-related information

Resource	ID	Description
InterPro	IPR009071	High mobility group, superfamily
InterPro	IPR022097	Transcription factor SOX
Protein Ontology	PR:000015427	transcription factor SOX-21

References

(Earliest) J:81702 Hwang CK, et al., Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins. J Biol Chem. 2003 Feb 7;278(6):3742-50
(Latest) J:187677 Matsuda S, et al., Sox21 Promotes Hippocampal Adult Neurogenesis via the Transcriptional Repression of the Hes5 Gene. J Neurosci. 2012 Sep 5;32(36):12543-12557
All references(40)