Aldh8a1
Gene Detail

Symbol Name ID

Aldh8a1 aldehyde dehydrogenase 8 family, member A1 MGI:2653900

Synonyms

RALDH4

Feature Type

protein coding gene

Genetic Map

Chromosome 10

9.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:21377291-21396585 bp, + strand From VEGA annotation of GRCm38   19295 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:23369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh8a1

Human homologs

Human Homolog		ALDH8A1, aldehyde dehydrogenase 8 family, member A1
NCBI Gene ID		64577
neXtProt AC		NX_Q9H2A2
Human Synonyms		ALDH12, DJ352A20.2
Human Chr (Location)		6q23.2; chr6:135238528-135271260 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	9-cis-retinoic acid biosynthetic process, metabolic process, ...
Component	cytoplasm, intracellular
Function	oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (41)    Tissues (11)    Images (26)
Theiler Stages: 14, 16, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	25
RT-PCR	16

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) cDNA(30) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000028021 (Evidence)
Ensembl Gene Model	ENSMUSG00000037542 (Evidence)
Entrez Gene	237320 (Evidence)
UniGene	90181
DFCI	TC1583238
DoTS	DT.40138910, DT.97354394, DT.97406297
NIA Mouse Gene Index	U011326
EC	1.2.1.-
Consensus CDS Project	CCDS23723.1
International Mouse Knockout Project Status	Aldh8a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028021	VEGA Gene Model | MGI Sequence Detail	19295	C57BL/6J
transcript	OTTMUST00000069398	VEGA | MGI Sequence Detail	2259	Not Applicable
polypeptide	OTTMUSP00000035243	VEGA | MGI Sequence Detail	487	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(136 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016160	Aldehyde dehydrogenase, conserved site
InterPro	IPR016163	Aldehyde dehydrogenase, C-terminal
InterPro	IPR015590	Aldehyde dehydrogenase domain
InterPro	IPR016162	Aldehyde dehydrogenase, N-terminal
InterPro	IPR016161	Aldehyde/histidinol dehydrogenase
Protein Ontology	PR:000003932	aldehyde dehydrogenase family 8 member A1

References

(Earliest) J:83534 Zhuang R, et al., cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells. Biochemistry. 2002 Mar 12;41(10):3477-83
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)