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Aldh8a1 Gene Detail
Summary
  • Symbol
    Aldh8a1
  • Name
    aldehyde dehydrogenase 8 family, member A1
  • Synonyms
    RALDH4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2653900
    NCBI Gene: 237320
Location & Maps
more
  • Sequence Map
    Chr10:21377291-21396585 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19295 bp   ±  kb flank

  • Genome Browsers
Homology
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  • Human Ortholog
    ALDH8A1, aldehyde dehydrogenase 8 family member A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALDH8A1, aldehyde dehydrogenase 8 family member A1
    Orthology source: HomoloGene
  • Synonyms
    ALDH12, DJ352A20.2
  • Links
    NCBI Gene ID: 64577
    neXtProt AC: NX_Q9H2A2

  • Chr Location
    6q23.2; chr6:134917390-134950122 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Aldh8a1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028021 VEGA Gene Model | MGI Sequence Detail 19295 C57BL/6J ±  kb
transcript OTTMUST00000069398 VEGA | MGI Sequence Detail 2259 Not Applicable  
polypeptide OTTMUSP00000035243 VEGA | MGI Sequence Detail 487 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    162 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000003932 aldehyde dehydrogenase family 8 member A1
  • EC
  • InterPro Domains
    IPR016163 Aldehyde dehydrogenase, C-terminal
    IPR016160 Aldehyde dehydrogenase, cysteine active site
    IPR015590 Aldehyde dehydrogenase domain
    IPR029510 Aldehyde dehydrogenase, glutamic acid active site
    IPR016162 Aldehyde dehydrogenase N-terminal domain
    IPR016161 Aldehyde/histidinol dehydrogenase
Molecular
Reagents
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  • All nucleic 32
    cDNA 30
    Primer pair 1
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:83534 Zhuang R, et al., cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells. Biochemistry. 2002 Mar 12;41(10):3477-83
  • Latest
    J:192460 Ioannou M, et al., ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol. 2013 Feb 1;374(1):153-63

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory