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Aldh8a1
Gene Detail
Symbol

Name
ID
Aldh8a1
aldehyde dehydrogenase 8 family, member A1
MGI:2653900
Synonyms
RALDH4
Feature Type
protein coding gene
Genetic Map
Chromosome 10
9.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:21377291-21396585 bp, + strand
From VEGA annotation of GRCm38

  19295 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23369  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ALDH8A1
Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh8a1

Human
homologs
ALDH8A1, aldehyde dehydrogenase 8 family, member A1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 64577
neXtProt AC: NX_Q9H2A2

Human Synonyms: ALDH12, DJ352A20.2

Human Chr (Location): 6q23.2; chr6:134917390-134950122 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Aldh8a1 interacts with 149 markers (Mir16-1, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (41)    Tissues (11)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
RT-PCR 16
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aldh8a1 ; ZFIN aldh8a1    NEW 
Molecular
reagents
All nucleic(32) cDNA(30) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000028021 (Evidence)
Ensembl Gene Model ENSMUSG00000037542 (Evidence)
Entrez Gene 237320 (Evidence)
UniGene 90181
DFCI TC1583238
DoTS DT.97406297, DT.97354394, DT.40138910
NIA Mouse Gene Index U011326
EC 1.2.1.-
Consensus CDS Project CCDS23723.1
International Mouse Phenotyping Consortium Status Aldh8a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028021 VEGA Gene Model | MGI Sequence Detail 19295 C57BL/6J ±  kb
transcript OTTMUST00000069398 VEGA | MGI Sequence Detail 2259 Not Applicable 
polypeptide OTTMUSP00000035243 VEGA | MGI Sequence Detail 487 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(162 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016160 Aldehyde dehydrogenase, conserved site
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
Protein Ontology PR:000003932 aldehyde dehydrogenase family 8 member A1
References
(Earliest) J:83534 Zhuang R, et al., cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells. Biochemistry. 2002 Mar 12;41(10):3477-83
(Latest) J:192460 Ioannou M, et al., ALDH1B1 is a potential stem/progenitor marker for multiple pancreas progenitor pools. Dev Biol. 2013 Feb 1;374(1):153-63
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory