Gpr156 MGI Mouse Gene Detail - MGI:2653880 - G protein-coupled receptor 156

Symbol

Gpr156
Name

G protein-coupled receptor 156
Synonyms

Gababl

Feature Type

protein coding gene
IDs

MGI:2653880
NCBI Gene: 239845
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr16:37736858-37827892 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 26.54 cM
Mapping Data

1 experiment

SNPs within 2kb

2349 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2653880	protein coding gene	Chr16:37736551-37827892 (+)
129S1/SvImJ	ENSMUSG00200028399	protein coding gene	Chr16:34672989-34764002 (+)
A/J	ENSMUSG00195010095	protein coding gene	Chr16:34218254-34309134 (+)
AKR/J	ENSMUSG00220026458	protein coding gene	Chr16:34606072-34696800 (+)
BALB/cJ	ENSMUSG00180012178	protein coding gene	Chr16:34433868-34524665 (+)
C3H/HeJ	ENSMUSG00175027880	protein coding gene	Chr16:34659922-34750938 (+)
C57BL/6NJ	ENSMUSG00215021041	protein coding gene	Chr16:34508619-34599669 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020735	protein coding gene	Chr16:34981391-35079430 (+)
CAST/EiJ	ENSTCUG00005030664	protein coding gene	Chr16:34966402-35057293 (+)
CBA/J	ENSMUSG00210027487	protein coding gene	Chr16:34717003-34808016 (+)
DBA/2J	ENSMUSG00185023925	protein coding gene	Chr16:34619999-34710978 (+)
FVB/NJ	ENSMUSG00205023683	protein coding gene	Chr16:34594416-34685290 (+)
JF1/MsJ	ENSUMUG00000026197	protein coding gene	Chr16:34862481-34952864 (+)
LP/J	ENSMUSG00230032094	protein coding gene	Chr16:37192156-37283160 (+)
NOD/ShiLtJ	ENSMUSG00190021705	protein coding gene	Chr16:34736968-34827976 (+)
NZO/HlLtJ	ENSMUSG00225038535	protein coding gene	Chr16:40291456-40382469 (+)
PWK/PhJ	ENSLUMG00010026766	protein coding gene	Chr16:34762940-34853334 (+)
SPRET/EiJ	ENSMSPG00010015378	protein coding gene	Chr16:34762914-34821178 (+)
WSB/EiJ	ENSIUOG00005024795	protein coding gene	Chr16:34819023-34909764 (+)

Human Ortholog

GPR156, G protein-coupled receptor 156

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR156, G protein-coupled receptor 156
Synonyms

DFNB121, GABABL, PGR28
Links

HGNC:20844

NCBI Gene ID: 165829

UniProt: Q8NFN8
Chr Location

3q13.33; chr3:120164645-120285426 (-) GRCh38

MGI Vertebrate Homology

Gpr156 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPR156
Gene Tree

Gpr156

Diseases

1 with human GPR156 associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness IDs autosomal recessive nonsyndromic deafness DOID:0050565 ICD10CM:H90.3 OMIM:607197 OMIM:PS220290 ORDO:90636

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 1 allele in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

7
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available

Homozygous null mice show an elevated reaction to stressors, with increased avoidance of stressors when possible, and increased struggling to escape when avoidance is not an option. Mice show hyperactivity of tonic medial habenula neurons which have a slightly depolarized resting membrane potential.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

617
Tissues

20
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

6
UniProt

2
CCDS

CCDS28162.1

Ensembl

ENSMUSG00000046961 (Evidence)
NCBI Gene

239845

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046961	Ensembl Gene Model \| MGI Sequence Detail	91035	C57BL/6J	± kb
transcript	ENSMUST00000061274	Ensembl \| MGI Sequence Detail	4584	Not Applicable
polypeptide	ENSMUSP00000055958	Ensembl \| MGI Sequence Detail	798	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031453 probable G-protein coupled receptor 156

(term hierarchy)
InterPro Domains

IPR017978 GPCR family 3, C-terminal

IPR002455 GPCR family 3, GABA-B receptor

IPR041946 GPR156, 7TM domain
GlyGen

Q6PCP7 1 site

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All nucleic 15

cDNA 14

Other 1

Microarray probesets 1

Summaries

All 40

Developmental Gene Expression 6

Diseases 1

Gene Ontology 7

Phenotypes 16
Earliest

J:82366 Calver AR, et al., Molecular cloning and characterisation of a novel GABA(B)-related G-protein coupled receptor. Brain Res Mol Brain Res. 2003 Feb 20;110(2):305-17
Latest

J:391707 Tarchini B, et al., Inner ear deficits complicate interpretation of depression-like behaviors in Gpr156 mutant mice. Proc Natl Acad Sci U S A. 2026 Sep;123(35):e2609064123

TSS for Gpr156:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138350	Chr16:37736802-37736836 (+)	-39 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24