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Agap1 Gene Detail
Summary
  • Symbol
    Agap1
  • Name
    ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  • Synonyms
    Centg2, Ggap1, mKIAA1099
  • Feature Type
    protein coding gene
  • IDs
    MGI:2653690
    NCBI Gene: 347722
  • Gene Overview
    MyGene.info: AGAP1
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:89454811-89895282 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 45.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3008 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2653690
protein coding gene Chr1:89454806-89897617 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016290
protein coding gene Chr1:90903718-91359471 (+)
A/J MGP_AJ_G0016271
protein coding gene Chr1:87644265-88096640 (+)
AKR/J MGP_AKRJ_G0016232
protein coding gene Chr1:90230646-90695920 (+)
BALB/cJ MGP_BALBcJ_G0016227
protein coding gene Chr1:87800141-88253984 (+)
C3H/HeJ MGP_C3HHeJ_G0016056
protein coding gene Chr1:90450317-90910619 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016686
protein coding gene Chr1:94433924-94897897 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014404
protein coding gene Chr1:81935016-82373465 (+)
CAST/EiJ MGP_CASTEiJ_G0015641
protein coding gene Chr1:89772033-90234337 (+)
CBA/J MGP_CBAJ_G0016032
protein coding gene Chr1:97462655-97937229 (+)
DBA/2J MGP_DBA2J_G0016135
protein coding gene Chr1:86873051-87320654 (+)
FVB/NJ MGP_FVBNJ_G0016134
protein coding gene Chr1:85891452-86337750 (+)
LP/J MGP_LPJ_G0016206
protein coding gene Chr1:92045070-92498243 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016159
protein coding gene Chr1:100755406-101218805 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016726
protein coding gene Chr1:90266887-90722444 (+)
PWK/PhJ MGP_PWKPhJ_G0015425
protein coding gene Chr1:86269983-86715098 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015208
protein coding gene Chr1:89180828-89621199 (+)
WSB/EiJ MGP_WSBEiJ_G0015699
protein coding gene Chr1:89989977-90454185 (+)



Homology
more
  • Human Ortholog
    AGAP1, ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AGAP1, ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGAP-1, CENTG2, cnt-g2, GGAP1
  • Links
    NCBI Gene ID: 116987
    neXtProt AC: NX_Q9UPQ3
    UniProt: Q9UPQ3

  • Chr Location
    2q37.2; chr2:235494089-236131800 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 347722 NCBI Gene Model | MGI Sequence Detail 440472 C57BL/6J ±  kb
    transcript NM_178119 RefSeq | MGI Sequence Detail 9581 C57BL/6  
    polypeptide Q8BXK8 UniProt | EBI | MGI Sequence Detail 857 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 145
      cDNA 144
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2138732
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:243971 Arnold M, et al., The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin. Front Cell Neurosci. 2016;10:218

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory