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Dmrta2 Gene Detail
Summary
  • Symbol
    Dmrta2
  • Name
    doublesex and mab-3 related transcription factor like family A2
  • Synonyms
    Dmrt5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2653629
    NCBI Gene: 242620
Location & Maps
more
  • Sequence Map
    Chr4:109978053-109983687 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5635 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 51.37 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DMRTA2, DMRT like family A2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DMRTA2, DMRT like family A2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 63950
    neXtProt AC: NX_Q96SC8

  • Chr Location
    1p32.3; chr1:50417550-50423447 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 3 alleles in 3 genetic backgrounds
    5 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    4 involving Dmrta2
  • Incidental Mutations
Mice homozygous for a targeted allele exhibit telencephalon hypoplasia, reduced cerebral cortex area, absent hippocampus, small olfactory bulb, disorganized medial cortex and decreased cortical neurons due to reduced proliferation of neuronal precursors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008499 VEGA Gene Model | MGI Sequence Detail 5635 C57BL/6J ±  kb
transcript OTTMUST00000019303 VEGA | MGI Sequence Detail 2922 Not Applicable  
polypeptide OTTMUSP00000008860 VEGA | MGI Sequence Detail 531 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    3 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006546 doublesex- and mab-3-related transcription factor A2
  • InterPro Domains
    IPR001275 DM DNA-binding domain
    IPR005173 DMRTA motif
    IPR026607 DMRT/protein doublesex/protein male abnormal 3
    IPR009060 UBA-like
Molecular
Reagents
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  • All nucleic 9
    cDNA 7
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:68323 Carninci P, et al., Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res. 2000 Oct;10(10):1617-30
  • Latest
    J:229226 Amaniti EM, et al., Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants. Cereb Cortex. 2015 Feb;25(2):460-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory