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Klf11 Gene Detail
Summary
  • Symbol
    Klf11
  • Name
    Kruppel-like factor 11
  • Synonyms
    D12Ertd427e, Tieg2, Tieg2b, Tieg3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2653368
    NCBI Gene: 194655
  • Gene Overview
    MyGene.info: KLF11
Location & Maps
more
  • Sequence Map
    Chr12:24651371-24662774 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11404 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.49 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KLF11, Kruppel like factor 11
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KLF11, Kruppel like factor 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKLF, FKLF1, MODY7, TIEG2, Tieg3
  • Links
    NCBI Gene ID: 8462
    neXtProt AC: NX_O14901

  • Chr Location
    2p25.1; chr2:10042985-10054836 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2668
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KLF11
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human KLF11 associations

Human Disease Mouse Models
       Maturity-Onset Diabetes of the Young, Type 7; MODY7   OMIM: 610508
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable and fertile, show normal hematopoiesis, growth and development, and display no evidence of increased tumor formation following gamma-irradiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027554 VEGA Gene Model | MGI Sequence Detail 11404 C57BL/6J ±  kb
transcript OTTMUST00000068231 VEGA | MGI Sequence Detail 3974 Not Applicable  
polypeptide OTTMUSP00000034445 VEGA | MGI Sequence Detail 502 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    157 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 64
    cDNA 62
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:1196399, MGI:2653358
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:236462 Delaney AA, et al., KLF10 Mediated Epigenetic Dysregulation of Epithelial CD40/CD154 Promotes Endometriosis. Biol Reprod. 2016 Sep;95(3):62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory