Klf11
Gene Detail

Symbol Name ID

Klf11 Kruppel-like factor 11 MGI:2653368

Synonyms

D12Ertd427e, Tieg2, Tieg2b, Tieg3

Feature Type

protein coding gene

Genetic Map

Chromosome 12

8.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr12:24651371-24662774 bp, + strand From VEGA annotation of GRCm38   11404 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2668  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Klf11

Human homologs

Human Homolog		KLF11, Kruppel-like factor 11
NCBI Gene ID		8462
neXtProt AC		NX_O14901
Human Synonyms		FKLF, FKLF1, MODY7, TIEG2, Tieg3
Human Chr (Location)		2p25; chr2:10183682-10194963 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KLF11

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a knock-out allele are viable and fertile, show normal hematopoiesis, growth and development, and display no evidence of increased tumor formation following gamma-irradiation.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	apoptotic process, negative regulation of cell proliferation, ...
Component	nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (93)    Tissues (46)    Images (11)
Theiler Stages: 2, 3, 4, 5, 10, 16, 17, 18, 19, 21, 23, 28

Assay Type	Results
RNA in situ	77
Northern blot	1
RT-PCR	15

cDNA source data(62)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(64) cDNA(62) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000027554 (Evidence)
Ensembl Gene Model	ENSMUSG00000020653 (Evidence)
Entrez Gene	194655 (Evidence)
UniGene	9616
DFCI	TC1575425, TC1595118
DoTS	DT.101369819, DT.492089, DT.91443958
NIA Mouse Gene Index	U013802
Consensus CDS Project	CCDS25842.1
International Mouse Knockout Project Status	Klf11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027554	VEGA Gene Model | MGI Sequence Detail	11404	C57BL/6J
transcript	OTTMUST00000068231	VEGA | MGI Sequence Detail	3974	Not Applicable
polypeptide	OTTMUSP00000034445	VEGA | MGI Sequence Detail	502	Not Applicable

All sequences(49) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000009355	krueppel-like factor 11

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:188861 Grunewald M, et al., Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. J Biol Chem. 2012 Jul 13;287(29):24195-206
All references(44)

Other accession IDs

MGI:1196399, MGI:2653358