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Klf11
Gene Detail
Symbol

Name
ID
Klf11
Kruppel-like factor 11
MGI:2653368
Synonyms
D12Ertd427e, Tieg2, Tieg2b, Tieg3
Feature Type
protein coding gene
Genetic Map
Chromosome 12
8.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:24651371-24662774 bp, + strand
From VEGA annotation of GRCm38

  11404 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2668  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: KLF11
Gene Tree: Klf11

Human
homologs
KLF11, Kruppel-like factor 11
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8462
neXtProt AC: NX_O14901

Human Synonyms: FKLF, FKLF1, MODY7, TIEG2, Tieg3

Human Chr (Location): 2p25; chr2:10042985-10054836 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KLF11

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile, show normal hematopoiesis, growth and development, and display no evidence of increased tumor formation following gamma-irradiation.
 
Interactions
Klf11 interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process apoptotic process, negative regulation of cell proliferation, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (86)    Tissues (41)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 77
Northern blot 1
RT-PCR 8
cDNA source data(62)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KLF11 ; Xenbase klf11 ; ZFIN klf11a, klf11b    NEW 
Molecular
reagents
All nucleic(64) cDNA(62) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000027554 (Evidence)
Ensembl Gene Model ENSMUSG00000020653 (Evidence)
Entrez Gene 194655 (Evidence)
UniGene 9616
DFCI TC1575425, TC1595118
DoTS DT.101369819, DT.492089, DT.91443958
NIA Mouse Gene Index U013802
Consensus CDS Project CCDS25842.1
International Mouse Phenotyping Consortium Status Klf11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027554 VEGA Gene Model | MGI Sequence Detail 11404 C57BL/6J ±  kb
transcript OTTMUST00000068231 VEGA | MGI Sequence Detail 3974 Not Applicable 
polypeptide OTTMUSP00000034445 VEGA | MGI Sequence Detail 502 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(161 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009355 krueppel-like factor 11
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:207531 Mathison A, et al., Role for Kruppel-like transcription factor 11 in mesenchymal cell function and fibrosis. PLoS One. 2013;8(9):e75311
All references(47)
Other
accession IDs
MGI:1196399, MGI:2653358

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory