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Klf11 Gene Detail
Summary
  • Symbol
    Klf11
  • Name
    Kruppel-like factor 11
  • Synonyms
    D12Ertd427e, Tieg2, Tieg2b, Tieg3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2653368
    NCBI Gene: 194655
  • Gene Overview
    MyGene.info: KLF11
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:24651371-24662782 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 8.49 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2653368
protein coding gene Chr12:24651274-24662789 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019630
protein coding gene Chr12:22332524-22343996 (+)
A/J MGP_AJ_G0019597
protein coding gene Chr12:21722740-21734220 (+)
AKR/J MGP_AKRJ_G0019568
protein coding gene Chr12:22454272-22465752 (+)
BALB/cJ MGP_BALBcJ_G0019574
protein coding gene Chr12:21992846-22004326 (+)
C3H/HeJ MGP_C3HHeJ_G0019378
protein coding gene Chr12:22332904-22344377 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020022
protein coding gene Chr12:23014908-23026311 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017646
protein coding gene Chr12:21207477-21218932 (+)
CAST/EiJ MGP_CASTEiJ_G0018933
protein coding gene Chr12:17282119-17293592 (+)
CBA/J MGP_CBAJ_G0019349
protein coding gene Chr12:23751491-23762964 (+)
DBA/2J MGP_DBA2J_G0019463
protein coding gene Chr12:21575633-21587113 (+)
FVB/NJ MGP_FVBNJ_G0019454
protein coding gene Chr12:21466886-21478366 (+)
LP/J MGP_LPJ_G0019533
protein coding gene Chr12:22399323-22410803 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019489
protein coding gene Chr12:23615354-23626834 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020061
protein coding gene Chr12:22013956-22025436 (+)
PWK/PhJ MGP_PWKPhJ_G0018700
protein coding gene Chr12:16305825-16317220 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018488
protein coding gene Chr12:16517533-16531356 (+)
WSB/EiJ MGP_WSBEiJ_G0018984
protein coding gene Chr12:22167374-22178854 (+)



Homology
more
  • Human Ortholog
    KLF11, Kruppel like factor 11
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KLF11, Kruppel like factor 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKLF, FKLF1, MODY7, TIEG2, Tieg3
  • Links
    NCBI Gene ID: 8462
    neXtProt AC: NX_O14901
    UniProt: O14901

  • Chr Location
    2p25.1; chr2:10043555-10054836 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2668
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KLF11
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human KLF11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Mice homozygous for a knock-out allele are viable and fertile, show normal hematopoiesis, growth and development, and display no evidence of increased tumor formation following gamma-irradiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 194655 NCBI Gene Model | MGI Sequence Detail 11412 C57BL/6J ±  kb
transcript NM_178357 RefSeq | MGI Sequence Detail 3982 C57BL/6  
polypeptide Q8K1S5 UniProt | EBI | MGI Sequence Detail 502 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 63
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:1196399, MGI:2653358
References
more
  • Summaries
    All 54
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 14
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:247028 Shenoy CC, et al., Progressive Fibrosis: A Progesterone- and KLF11-Mediated Sexually Dimorphic Female Response. Endocrinology. 2017 Oct 01;158(10):3605-3619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory