Klf11 MGI Mouse Gene Detail - MGI:2653368 - Kruppel-like transcription factor 11

Symbol

Klf11
Name

Kruppel-like transcription factor 11
Synonyms

D12Ertd427e, Tieg2, Tieg2b, Tieg3

Feature Type

protein coding gene
IDs

MGI:2653368
NCBI Gene: 194655
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:24701370-24712781 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 8.49 cM
Mapping Data

4 experiments

SNPs within 2kb

157 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2653368	protein coding gene	Chr12:24701273-24712788 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019630	protein coding gene	Chr12:22332524-22343996 (+)
A/J	MGP_AJ_G0019597	protein coding gene	Chr12:21722740-21734220 (+)
AKR/J	MGP_AKRJ_G0019568	protein coding gene	Chr12:22454272-22465752 (+)
BALB/cJ	MGP_BALBcJ_G0019574	protein coding gene	Chr12:21992846-22004326 (+)
C3H/HeJ	MGP_C3HHeJ_G0019378	protein coding gene	Chr12:22332904-22344377 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020022	protein coding gene	Chr12:23014908-23026311 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017646	protein coding gene	Chr12:21207477-21218932 (+)
CAST/EiJ	MGP_CASTEiJ_G0018933	protein coding gene	Chr12:17282119-17293592 (+)
CBA/J	MGP_CBAJ_G0019349	protein coding gene	Chr12:23751491-23762964 (+)
DBA/2J	MGP_DBA2J_G0019463	protein coding gene	Chr12:21575633-21587113 (+)
FVB/NJ	MGP_FVBNJ_G0019454	protein coding gene	Chr12:21466886-21478366 (+)
LP/J	MGP_LPJ_G0019533	protein coding gene	Chr12:22399323-22410803 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019489	protein coding gene	Chr12:23615354-23626834 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020061	protein coding gene	Chr12:22013956-22025436 (+)
PWK/PhJ	MGP_PWKPhJ_G0018700	protein coding gene	Chr12:16305825-16317220 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018488	protein coding gene	Chr12:16517533-16531356 (+)
WSB/EiJ	MGP_WSBEiJ_G0018984	protein coding gene	Chr12:22167374-22178854 (+)

Human Ortholog

KLF11, KLF transcription factor 11

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLF11, KLF transcription factor 11
Synonyms

FKLF, FKLF1, MODY7, TIEG2, Tieg3
Links

HGNC:11811

NCBI Gene ID: 8462

neXtProt AC: NX_O14901

UniProt: O14901
Chr Location

2p25.1; chr2:10042849-10054836 (+) GRCh38

MGI Vertebrate Homology

Klf11 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KLF11
Gene Tree

Klf11

Diseases

2 with human KLF11 associations

				Human Disease	Mouse Models
				maturity-onset diabetes of the young type 7 IDs maturity-onset diabetes of the young type 7 DOID:0111106 OMIM:610508
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 2 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and fertile, show normal hematopoiesis, growth and development, and display no evidence of increased tumor formation following gamma-irradiation.

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All GO Annotations

31
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

897
Tissues

78
cDNA Data

63
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KLF11

Xenbase klf11

ZFIN klf11a, klf11b

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All Sequences

52
RefSeq

2
UniProt

4
CCDS

CCDS25842.1

Ensembl

ENSMUSG00000020653 (Evidence)
NCBI Gene

194655

			Length	Strain/Species	Flank
genomic	194655	NCBI Gene Model \| MGI Sequence Detail	11412	C57BL/6J	± kb
transcript	NM_178357	RefSeq \| MGI Sequence Detail	3982	ZRU/MplStud
polypeptide	Q8K1S5	UniProt \| EBI \| MGI Sequence Detail	502	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009355 krueppel-like factor 11

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 66

cDNA 63

Primer pair 3

Microarray probesets 3

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MGI:1196399, MGI:2653358

Summaries

All 69

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 26
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:337911 Grande J, et al., Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis. Biochim Biophys Acta Mol Basis Dis. 2023 Jun 13;1869(7):166784

TSS for Klf11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112956	Chr12:24701345-24701408 (+)	7 bp
Tssr112957	Chr12:24701420-24701431 (+)	56 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23