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Unc80 Gene Detail
Summary
  • Symbol
    Unc80
  • Name
    unc-80, NALCN activator
  • Synonyms
    C030018G13Rik, C230061B10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652882
    NCBI Gene: 329178
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:66468367-66699148 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 33.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2319 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652882
protein coding gene Chr1:66467915-66699150 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016113
protein coding gene Chr1:66736035-66961792 (+)
A/J MGP_AJ_G0016096
protein coding gene Chr1:64375958-64591481 (+)
AKR/J MGP_AKRJ_G0016053
protein coding gene Chr1:66197034-66436327 (+)
BALB/cJ MGP_BALBcJ_G0016051
protein coding gene Chr1:64436268-64665835 (+)
C3H/HeJ MGP_C3HHeJ_G0015882
protein coding gene Chr1:66447407-66687847 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016504
protein coding gene Chr1:69291928-69545455 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014225
protein coding gene Chr1:60328407-60527488 (+)
CAST/EiJ MGP_CASTEiJ_G0015466
protein coding gene Chr1:65694686-65921970 (+)
CBA/J MGP_CBAJ_G0015855
protein coding gene Chr1:71533732-71787281 (+)
DBA/2J MGP_DBA2J_G0015956
protein coding gene Chr1:63759997-63982096 (+)
FVB/NJ MGP_FVBNJ_G0015959
protein coding gene Chr1:63015768-63234764 (+)
LP/J MGP_LPJ_G0016028
protein coding gene Chr1:67671368-67903385 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015979
protein coding gene Chr1:74507682-74759756 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016551
protein coding gene Chr1:66148904-66387448 (+)
PWK/PhJ MGP_PWKPhJ_G0015253
protein coding gene Chr1:63151168-63375721 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015032
protein coding gene Chr1:65621890-65851272 (+)
WSB/EiJ MGP_WSBEiJ_G0015528
protein coding gene Chr1:65887200-66115381 (+)



Homology
more
  • Human Ortholog
    UNC80, unc-80 homolog, NALCN channel complex subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    UNC80, unc-80 homolog, NALCN channel complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C2orf21, UNC-80
  • Links
    NCBI Gene ID: 285175
    neXtProt AC: NX_Q8N2C7
    UniProt: Q8N2C7

  • Chr Location
    2q34; chr2:209771925-209999300 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die within 24 hours of birth, exhibit severe apnea and hippocampal neurons show decreased NALCN-dependent sodium leak current.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055567 Ensembl Gene Model | MGI Sequence Detail 230782 C57BL/6J ±  kb
    transcript ENSMUST00000061620 Ensembl | MGI Sequence Detail 13613 Not Applicable  
    polypeptide ENSMUSP00000053692 Ensembl | MGI Sequence Detail 3326 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1925858, MGI:2445028
    References
    more
    • Summaries
      All 32
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:291847 Wie J, et al., Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex. Nat Commun. 2020 Jul 3;11(1):3351

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/13/2020
    MGI 6.16
    The Jackson Laboratory