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Wnk3 Gene Detail
Summary
  • Symbol
    Wnk3
  • Name
    WNK lysine deficient protein kinase 3
  • Synonyms
    Prkwnk3, PRKWNK3, Wnk3, Wnk3-ps
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652875
    NCBI Gene: 279561
  • Gene Overview
    MyGene.info: WNK3
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:151198078-151320152 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    499 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652875
protein coding gene ChrX:151168778-151320194 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036176
protein coding gene ChrX:148905353-149065414 (+)
A/J MGP_AJ_G0036152
protein coding gene ChrX:148121620-148264628 (+)
AKR/J MGP_AKRJ_G0036078
protein coding gene ChrX:152898189-153054936 (+)
BALB/cJ MGP_BALBcJ_G0036143
protein coding gene ChrX:146310749-146460053 (+)
C3H/HeJ MGP_C3HHeJ_G0035851
protein coding gene ChrX:149115781-149269442 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036668
protein coding gene ChrX:153171696-153299439 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033492
protein coding gene ChrX:139871710-140002630 (+)
CAST/EiJ MGP_CASTEiJ_G0035142
protein coding gene ChrX:128586794-128703546 (+)
CBA/J MGP_CBAJ_G0035828
protein coding gene ChrX:157663080-157824915 (+)
DBA/2J MGP_DBA2J_G0035986
protein coding gene ChrX:147196835-147360354 (+)
FVB/NJ MGP_FVBNJ_G0035920
protein coding gene ChrX:146340322-146485517 (+)
LP/J MGP_LPJ_G0036077
protein coding gene ChrX:150019171-150138036 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035956
protein coding gene ChrX:165803371-165947328 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036703
protein coding gene ChrX:148440597-148559486 (+)
PWK/PhJ MGP_PWKPhJ_G0034836
protein coding gene ChrX:125525287-125680037 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034662
protein coding gene ChrX:129048782-129165328 (+)
WSB/EiJ MGP_WSBEiJ_G0035277
protein coding gene ChrX:146511891-146661838 (+)



Homology
more
  • Human Ortholog
    WNK3, WNK lysine deficient protein kinase 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    WNK3, WNK lysine deficient protein kinase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PRKWNK3
  • Links
    NCBI Gene ID: 65267
    neXtProt AC: NX_Q9BYP7
    UniProt: Q9BYP7

  • Chr Location
    Xp11.22; chrX:54192823-54358695 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lower blood pressure when fed a low-salt diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041245 Ensembl Gene Model | MGI Sequence Detail 122075 C57BL/6J ±  kb
transcript ENSMUST00000096285 Ensembl | MGI Sequence Detail 8551 Not Applicable  
polypeptide ENSMUSP00000138839 Ensembl | MGI Sequence Detail 1789 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
    IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:2182463
References
more
  • Summaries
    All 34
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:264975 Zhao H, et al., Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. J Cereb Blood Flow Metab. 2017 Feb;37(2):550-563

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory