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Wnk3
Gene Detail
 Symbol
Name
ID
Wnk3
WNK lysine deficient protein kinase 3
MGI:2652875
Synonyms Prkwnk3, PRKWNK3, Wnk3, Wnk3-ps
Feature Type protein coding gene
Genetic Map
Chromosome X
68.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:151198078-151320152 bp, + strand
From VEGA annotation of GRCm38

  122075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Wnk3

Human
homologs
Human Homolog WNK3, WNK lysine deficient protein kinase 3
NCBI Gene ID 65267
neXtProt AC  NX_Q9BYP7
Human Synonyms  PRKWNK3
Human Chr (Location)  Xp11.22; chrX:54192823-54358005 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(4) Targeted(1)
 
Mice homozygous for a knock-out allele exhibit lower blood pressure when fed a low-salt diet.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process negative regulation of apoptotic process, phosphorylation, ...
Component adherens junction, cytoplasm, ...
Function ATP binding, chloride channel inhibitor activity, ...
External Resources: FuncBase
Expression
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019169 (Evidence)
Ensembl Gene ModelENSMUSG00000041245 (Evidence)
Entrez Gene279561 (Evidence)
DFCITC1617718, TC1619624
DoTSDT.101367747
NIA Mouse Gene IndexU020310
EC2.7.11.1
Consensus CDS ProjectCCDS72450.1, CCDS72451.1
International Mouse Knockout Project StatusWnk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019169 VEGA Gene Model | MGI Sequence Detail 122075 C57BL/6J ±  kb
transcript OTTMUST00000117340 VEGA | MGI Sequence Detail 5394 Not Applicable 
polypeptide OTTMUSP00000065617 VEGA | MGI Sequence Detail 1757 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(14) UniProt(3)
Polymorphisms SNPs within 2kb(413 from dbSNP Build 137)    SNPs within 2kb including multiple locations(415)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology PR:000017433 serine/threonine-protein kinase WNK3
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:197267 Mederle K, et al., Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse. Am J Physiol Renal Physiol. 2013 May 1;304(9):F1198-209
All references(34)
Other
accession IDs
MGI:2182463

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory