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Asic4 Gene Detail
Summary
  • Symbol
    Asic4
  • Name
    acid-sensing (proton-gated) ion channel family member 4
  • Synonyms
    Accn4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652846
    NCBI Gene: 241118
  • Gene Overview
    MyGene.info: ASIC4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:75450510-75474340 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 39.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652846
protein coding gene Chr1:75450436-75474343 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016188
protein coding gene Chr1:76023127-76052102 (+)
A/J MGP_AJ_G0016171
protein coding gene Chr1:73373539-73398415 (+)
AKR/J MGP_AKRJ_G0016128
protein coding gene Chr1:75409606-75432355 (+)
BALB/cJ MGP_BALBcJ_G0016126
protein coding gene Chr1:73436853-73461019 (+)
C3H/HeJ MGP_C3HHeJ_G0015957
protein coding gene Chr1:75739859-75765256 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016579
protein coding gene Chr1:78974486-79006305 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014300
protein coding gene Chr1:68932726-68957551 (+)
CAST/EiJ MGP_CASTEiJ_G0015541
protein coding gene Chr1:75085135-75110262 (+)
CBA/J MGP_CBAJ_G0015930
protein coding gene Chr1:81545609-81583830 (+)
DBA/2J MGP_DBA2J_G0016031
protein coding gene Chr1:72693741-72717764 (+)
FVB/NJ MGP_FVBNJ_G0016034
protein coding gene Chr1:71897558-71923928 (+)
LP/J MGP_LPJ_G0016103
protein coding gene Chr1:77148827-77179474 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016054
protein coding gene Chr1:84891418-84918368 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016626
protein coding gene Chr1:75477103-75502248 (+)
PWK/PhJ MGP_PWKPhJ_G0015328
protein coding gene Chr1:72169640-72193722 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015106
protein coding gene Chr1:74836405-74858214 (+)
WSB/EiJ MGP_WSBEiJ_G0015603
protein coding gene Chr1:75288315-75311819 (+)



Homology
more
  • Human Ortholog
    ASIC4, acid sensing ion channel subunit family member 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ASIC4, acid sensing ion channel subunit family member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACCN4, BNAC4
  • Links
    NCBI Gene ID: 55515
    neXtProt AC: NX_Q96FT7
    UniProt: Q96FT7

  • Chr Location
    2q35; chr2:219514170-219538772 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11166
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ASIC4
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout increases the fear response in the predator-odor induced fear test and increases anxiety in open field and elevated plus maze tests.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 241118 NCBI Gene Model | MGI Sequence Detail 23831 C57BL/6J ±  kb
    transcript NM_183022 RefSeq | MGI Sequence Detail 2650 C57BL/6  
    polypeptide Q7TNS7 UniProt | EBI | MGI Sequence Detail 539 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 2
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 3
      Phenotypes 27
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:250120 Hoshikawa M, et al., Distribution of ASIC4 transcripts in the adult wild-type mouse brain. Neurosci Lett. 2017 Jun 09;651:57-64

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory