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Zfyve9 Gene Detail
Summary
  • Symbol
    Zfyve9
  • Name
    zinc finger, FYVE domain containing 9
  • Synonyms
    Madhip
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652838
    NCBI Gene: 230597
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:108494663-108637995 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 50.64 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    797 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652838
protein coding gene Chr4:108494663-108642514 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028559
protein coding gene Chr4:109389007-109533462 (-)
A/J MGP_AJ_G0028522
protein coding gene Chr4:105447663-105584618 (-)
AKR/J MGP_AKRJ_G0028469
protein coding gene Chr4:108074888-108217100 (-)
BALB/cJ MGP_BALBcJ_G0028541
protein coding gene Chr4:105656754-105794581 (-)
C3H/HeJ MGP_C3HHeJ_G0028255
protein coding gene Chr4:108797839-108944311 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028981
protein coding gene Chr4:113306772-113456178 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026272
protein coding gene Chr4:100733152-100877074 (-)
CAST/EiJ MGP_CASTEiJ_G0027691
protein coding gene Chr4:106654946-106803666 (-)
CBA/J MGP_CBAJ_G0028224
protein coding gene Chr4:117035301-117194159 (-)
DBA/2J MGP_DBA2J_G0028372
protein coding gene Chr4:105080379-105216842 (-)
FVB/NJ MGP_FVBNJ_G0028340
protein coding gene Chr4:103947423-104082942 (-)
LP/J MGP_LPJ_G0028473
protein coding gene Chr4:109630923-109771066 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028366
protein coding gene Chr4:122234455-122389577 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029017
protein coding gene Chr4:108314546-108458199 (-)
PWK/PhJ MGP_PWKPhJ_G0027417
protein coding gene Chr4:103356026-103498474 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027241
protein coding gene Chr4:105646547-105802218 (-)
WSB/EiJ MGP_WSBEiJ_G0027772
protein coding gene Chr4:108493888-108635633 (-)



Homology
more
  • Human Ortholog
    ZFYVE9, zinc finger FYVE-type containing 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFYVE9, zinc finger FYVE-type containing 9
  • Synonyms
    MADHIP, NSP, PPP1R173, SARA, SMADIP
  • Links
    NCBI Gene ID: 9372
    neXtProt AC: NX_O95405
    UniProt: O95405

  • Chr Location
    1p32.3; chr1:52142001-52348664 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034557 Ensembl Gene Model | MGI Sequence Detail 143333 C57BL/6J ±  kb
transcript ENSMUST00000106657 Ensembl | MGI Sequence Detail 6459 Not Applicable  
polypeptide ENSMUSP00000102268 Ensembl | MGI Sequence Detail 1397 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000000125 zinc finger FYVE domain-containing protein 9
  • InterPro Domains
    IPR022557 Domain of unknown function DUF3480
    IPR000306 FYVE zinc finger
    IPR024608 Smad anchor for receptor activation, Smad-binding domain
    IPR037145 Smad anchor for receptor activation, Smad-binding domain superfamily
    IPR035438 Zinc finger FYVE domain containing protein, SARA/endofin
    IPR011011 Zinc finger, FYVE/PHD-type
    IPR017455 Zinc finger, FYVE-related
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
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  • All nucleic 18
    cDNA 14
    Primer pair 4

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:236412 Mestres I, et al., SARA regulates neuronal migration during neocortical development through L1 trafficking. Development. 2016 Sep 1;143(17):3143-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/08/2021
MGI 6.17
The Jackson Laboratory