About   Help   FAQ
Zfyve9 Gene Detail
Summary
  • Symbol
    Zfyve9
  • Name
    zinc finger, FYVE domain containing 9
  • Synonyms
    Madhip
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652838
    NCBI Gene: 230597
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:108494663-108637995 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 50.64 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3264 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652838
 protein coding gene Chr4:108494663-108642514 (-)
129S1/SvImJ ENSMUSG00200047697
 protein coding gene Chr4:103547075-103682636 (-)
A/J ENSMUSG00195044028
 protein coding gene Chr4:104090100-104225671 (-)
AKR/J ENSMUSG00220011865
 protein coding gene Chr4:103475824-103611394 (-)
BALB/cJ ENSMUSG00180044109
 protein coding gene Chr4:102918578-103054584 (-)
C3H/HeJ ENSMUSG00175035966
 protein coding gene Chr4:103922970-104058965 (-)
C57BL/6NJ ENSMUSG00215015318
 protein coding gene Chr4:103827933-103971270 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026272
 protein coding gene Chr4:100733152-100877074 (-)
CAST/EiJ ENSTCUG00005020942
 protein coding gene Chr4:103032881-103168650 (-)
CBA/J ENSMUSG00210052392
 protein coding gene Chr4:103555991-103691978 (-)
DBA/2J ENSMUSG00185045162
 protein coding gene Chr4:104267099-104403138 (-)
FVB/NJ ENSMUSG00205020282
 protein coding gene Chr4:102500451-102636004 (-)
JF1/MsJ ENSUMUG00000044628
 protein coding gene Chr4:104280452-104418399 (-)
LP/J ENSMUSG00230006271
 protein coding gene Chr4:107583437-107718993 (-)
NOD/ShiLtJ ENSMUSG00190039217
 protein coding gene Chr4:102925755-103061750 (-)
NZO/HlLtJ ENSMUSG00225032090
 protein coding gene Chr4:112685622-112821646 (-)
PWK/PhJ ENSLUMG00010040506
 protein coding gene Chr4:101995602-102133065 (-)
SPRET/EiJ ENSMSPG00010025447
 protein coding gene Chr4:104217970-104357869 (-)
WSB/EiJ ENSIUOG00005035049
 protein coding gene Chr4:103126573-103262390 (-)



Homology
more
  • Human Ortholog
    ZFYVE9, zinc finger FYVE-type containing 9
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFYVE9, zinc finger FYVE-type containing 9
  • Synonyms
    MADHIP, NSP, PPP1R173, SARA, SMADIP
  • Links
    NCBI Gene ID: 9372
    UniProt: O95405

  • Chr Location
    1p32.3; chr1:52141888-52348671 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    645
  • Tissues
    30
  • cDNA Data
    14
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034557 Ensembl Gene Model | MGI Sequence Detail 143333 C57BL/6J ±  kb
transcript ENSMUST00000106657 Ensembl | MGI Sequence Detail 6459 Not Applicable  
polypeptide ENSMUSP00000102268 Ensembl | MGI Sequence Detail 1397 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000000125 zinc finger FYVE domain-containing protein 9
    (term hierarchy)
  • InterPro Domains
    IPR000306 FYVE zinc finger
    IPR022557 Smad anchor for receptor activation-like, C-terminal
    IPR024608 Smad anchor for receptor activation-like, Smad-binding domain
    IPR037145 Smad anchor for receptor activation, Smad-binding domain superfamily
    IPR035438 Zinc finger FYVE domain containing protein, SARA/endofin
    IPR011011 Zinc finger, FYVE/PHD-type
    IPR017455 Zinc finger, FYVE-related
    IPR013083 Zinc finger, RING/FYVE/PHD-type
  • GlyGen
    A2A8R0 2 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 14
    Primer pair 4
    Antibodies 4

    Microarray probesets 2
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:236412 Mestres I, et al., SARA regulates neuronal migration during neocortical development through L1 trafficking. Development. 2016 Sep 1;143(17):3143-53
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory