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Gmeb2 Gene Detail
Summary
  • Symbol
    Gmeb2
  • Name
    glucocorticoid modulatory element binding protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652836
    NCBI Gene: 229004
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180893242-180929828 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 103.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    553 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652836
 protein coding gene Chr2:180893240-180933481 (-)
129S1/SvImJ ENSMUSG00200002306
 protein coding gene Chr2:176915789-176952378 (-)
A/J ENSMUSG00195001088
 protein coding gene Chr2:177148129-177184750 (-)
AKR/J ENSMUSG00220000068
 protein coding gene Chr2:174826774-174863391 (-)
BALB/cJ ENSMUSG00180000546
 protein coding gene Chr2:174955064-174991669 (-)
C3H/HeJ ENSMUSG00175004356
 protein coding gene Chr2:176108706-176145320 (-)
C57BL/6NJ ENSMUSG00215002487
 protein coding gene Chr2:175055283-175091875 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024802
 protein coding gene Chr2:170786447-170825425 (-)
CAST/EiJ ENSTCUG00005000762
 protein coding gene Chr2:174405414-174442104 (-)
CBA/J ENSMUSG00210001144
 protein coding gene Chr2:175433628-175470230 (-)
DBA/2J ENSMUSG00185019988
 protein coding gene Chr2:176668158-176704773 (-)
FVB/NJ ENSMUSG00205002279
 protein coding gene Chr2:175485378-175521981 (-)
JF1/MsJ ENSUMUG00000022606
 protein coding gene Chr2:177860032-177897427 (-)
LP/J ENSMUSG00230021981
 protein coding gene Chr2:178566732-178603318 (-)
NOD/ShiLtJ ENSMUSG00190015797
 protein coding gene Chr2:174975204-175011799 (-)
NZO/HlLtJ ENSMUSG00225006321
 protein coding gene Chr2:186649405-186685963 (-)
PWK/PhJ ENSLUMG00010000220
 protein coding gene Chr2:175280156-175317008 (-)
SPRET/EiJ ENSMSPG00010003997
 protein coding gene Chr2:177754702-177791104 (-)
WSB/EiJ ENSIUOG00005000101
 protein coding gene Chr2:174994247-175030873 (-)



Homology
more
  • Human Ortholog
    GMEB2, glucocorticoid modulatory element binding protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GMEB2, glucocorticoid modulatory element binding protein 2
  • Synonyms
    GMEB-2, P79PIF, PIF79
  • Links
    NCBI Gene ID: 26205
    UniProt: Q9UKD1

  • Chr Location
    20q13.33; chr20:63587601-63628426 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    4 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased embryo size, embryonic growth retardation, incomplete embryo turning, abnormal head shape, mild caudal neural tube kinks, abnormal tails, placentation defects, and complete lethality during organogenesis. A minority exhibit abnormal hearts and some have abnormally vascularized yolk sacs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    19
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038705 Ensembl Gene Model | MGI Sequence Detail 36587 C57BL/6J ±  kb
    transcript ENSMUST00000049032 Ensembl | MGI Sequence Detail 4121 Not Applicable  
    polypeptide ENSMUSP00000037075 Ensembl | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139064
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:61774 Zeng H, et al., Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins. Nucleic Acids Res. 2000 Apr 15;28(8):1819-29
    • Latest
      J:386951 Guertin TM, et al., Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15;153(10):dev205276
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory