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Dcdc2a Gene Detail
Summary
  • Symbol
    Dcdc2a
  • Name
    doublecortin domain containing 2a
  • Synonyms
    Dcdc2, MGC:54817, RU2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652818
    NCBI Gene: 195208
  • Gene Overview
    MyGene.info: DCDC2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:25056004-25210706 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 10.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1881 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652818
protein coding gene Chr13:25055232-25210706 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020387
protein coding gene Chr13:22559660-22713729 (+)
A/J MGP_AJ_G0020336
protein coding gene Chr13:22140819-22306320 (+)
AKR/J MGP_AKRJ_G0020316
protein coding gene Chr13:22385311-22549956 (+)
BALB/cJ MGP_BALBcJ_G0020334
protein coding gene Chr13:22121543-22285672 (+)
C3H/HeJ MGP_C3HHeJ_G0020138
protein coding gene Chr13:22448719-22606324 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020771
protein coding gene Chr13:23357841-23516744 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018359
protein coding gene Chr13:20843694-20998899 (+)
CAST/EiJ MGP_CASTEiJ_G0019655
protein coding gene Chr13:22169655-22335791 (+)
CBA/J MGP_CBAJ_G0020092
protein coding gene Chr13:24253930-24422632 (+)
DBA/2J MGP_DBA2J_G0020218
protein coding gene Chr13:21640963-21799376 (+)
FVB/NJ MGP_FVBNJ_G0020202
protein coding gene Chr13:21276379-21433563 (+)
LP/J MGP_LPJ_G0020291
protein coding gene Chr13:22859017-23019538 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020229
protein coding gene Chr13:24485160-24645735 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020813
protein coding gene Chr13:22240850-22402573 (+)
PWK/PhJ MGP_PWKPhJ_G0019409
protein coding gene Chr13:21642776-21803137 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019225
protein coding gene Chr13:21061229-21234599 (+)
WSB/EiJ MGP_WSBEiJ_G0019715
protein coding gene Chr13:22394250-22566682 (+)



Homology
more
  • Human Ortholog
    DCDC2, doublecortin domain containing 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DCDC2, doublecortin domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DCDC2A, DFNB66, NPHP19, NSC, RU2, RU2S
  • Links
    NCBI Gene ID: 51473
    neXtProt AC: NX_Q9UHG0
    UniProt: Q9UHG0

  • Chr Location
    6p22.3; chr6:24171755-24383292 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human DCDC2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired short term object recognition, impaired visuo-spatial learning and memory and increased anxiety-related response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035910 Ensembl Gene Model | MGI Sequence Detail 154703 C57BL/6J ±  kb
transcript ENSMUST00000069614 Ensembl | MGI Sequence Detail 6634 Not Applicable  
polypeptide ENSMUSP00000063650 Ensembl | MGI Sequence Detail 475 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 14
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145433
References
more
  • Summaries
    All 44
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:243473 Che A, et al., Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex. Cereb Cortex. 2016 Sep;26(9):3705-3718

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory