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Pttg1ip Gene Detail
Summary
  • Symbol
    Pttg1ip
  • Name
    pituitary tumor-transforming 1 interacting protein
  • Synonyms
    1810010L20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652132
    NCBI Gene: 108705
  • Gene Overview
    MyGene.info: PTTG1IP
Location & Maps
more
  • Sequence Map
    Chr10:77581720-77598732 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      17013 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PTTG1IP, pituitary tumor-transforming 1 interacting protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PTTG1IP, pituitary tumor-transforming 1 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C21orf1, C21orf3, PBF
  • Links
    NCBI Gene ID: 754
    neXtProt AC: NX_P53801

  • Chr Location
    21q22.3; chr21:44849585-44873903 (-)  GRCh38.p2
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotype references
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Targeted
    6
  • Genomic Mutations
    4 involving Pttg1ip
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    270
  • Tissues
    153
  • cDNA Data
    26
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035073 VEGA Gene Model | MGI Sequence Detail 17013 C57BL/6J ±  kb
transcript OTTMUST00000089237 VEGA | MGI Sequence Detail 2294 Not Applicable  
polypeptide OTTMUSP00000048728 VEGA | MGI Sequence Detail 174 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    45 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000013487 pituitary tumor-transforming gene 1 protein-interacting protein
  • InterPro Domains
    IPR016201 PSI domain
Molecular
Reagents
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  • All nucleic 28
    cDNA 26
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGI:1916311, MGI:2143562, MGI:2143728, MGI:2143927
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Diseases 2
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:210172 Read ML, et al., The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Endocrinology. 2014 Apr;155(4):1222-34
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory