Pttg1ip MGI Mouse Gene Detail - MGI:2652132 - pituitary tumor-transforming 1 interacting protein

Pttg1ip Gene Detail

Symbol

Pttg1ip
Name

pituitary tumor-transforming 1 interacting protein
Synonyms

1810010L20Rik

Feature Type

protein coding gene
IDs

MGI:2652132
NCBI Gene: 108705
Gene Overview

MyGene.info: PTTG1IP

Sequence Map

Chr10:77581720-77598732 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

17013 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

Human Ortholog

PTTG1IP, PTTG1 interacting protein

Vertebrate Orthologs

11

Human Ortholog

PTTG1IP, PTTG1 interacting protein
Orthology source: HomoloGene, HGNC
Synonyms

C21orf1, C21orf3, PBF
Links

HGNC:13524

NCBI Gene ID: 754

neXtProt AC: NX_P53801

UniProt: P53801
Chr Location

21q22.3; chr21:44849585-44873903 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3203
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;2 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PTTG1IP
Gene Tree

Pttg1ip

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References

2 with disease annotations

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Phenotype Summary

20 phenotype references

All Mutations and Alleles

18
Chemically induced (other)

1
Gene trapped

11
Targeted

6
Genomic Mutations

4 involving Pttg1ip
Incidental Mutations

APF
Find Mice (IMSR)

2 strains or lines available

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All GO Annotations

16
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

270
Tissues

153
cDNA Data

26
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pttg1ip.1, pttg1ip.2

ZFIN pttg1ipb

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Pttg1ip interacts with 214 markers (Mir1a-2, Mir1b, Mir7-1, ...) View All

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All Sequences

105
RefSeq

4
UniProt

7
CCDS

CCDS23957.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035073	VEGA Gene Model \| MGI Sequence Detail	17013	C57BL/6J	± kb
transcript	OTTMUST00000089237	VEGA \| MGI Sequence Detail	2294	Not Applicable
polypeptide	OTTMUSP00000048728	VEGA \| MGI Sequence Detail	174	Not Applicable

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SNPs within 2kb

45 from dbSNP Build 142

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UniProt

7 Sequences
Protein Ontology

PR:000013487 pituitary tumor-transforming gene 1 protein-interacting protein

(term hierarchy)
InterPro Domains

IPR016201 PSI domain

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All nucleic 28

cDNA 26

Primer pair 2

Microarray probesets 5

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MGI:1916311, MGI:2143562, MGI:2143728, MGI:2143927

Summaries

All 49

Developmental Gene Expression 4

Diseases 2

Gene Ontology 4

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:238605 Belichenko PV, et al., Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues. PLoS One. 2015;10(7):e0134861

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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