Pttg1ip MGI Mouse Gene Detail - MGI:2652132 - pituitary tumor-transforming 1 interacting protein

Symbol

Pttg1ip
Name

pituitary tumor-transforming 1 interacting protein
Synonyms

1810010L20Rik

Feature Type

protein coding gene
IDs

MGI:2652132
NCBI Gene: 108705
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:77417554-77434566 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

463 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2652132	protein coding gene	Chr10:77417489-77434566 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017399	protein coding gene	Chr10:77916378-77934534 (+)
A/J	MGP_AJ_G0017376	protein coding gene	Chr10:75203446-75220675 (+)
AKR/J	MGP_AKRJ_G0017337	protein coding gene	Chr10:77209448-77229255 (+)
BALB/cJ	MGP_BALBcJ_G0017336	protein coding gene	Chr10:75398023-75415597 (+)
C3H/HeJ	MGP_C3HHeJ_G0017160	protein coding gene	Chr10:77296056-77312925 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017794	protein coding gene	Chr10:80632874-80650057 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015484	protein coding gene	Chr10:71634528-71652164 (+)
CAST/EiJ	MGP_CASTEiJ_G0016730	protein coding gene	Chr10:77652281-77669361 (+)
CBA/J	MGP_CBAJ_G0017132	protein coding gene	Chr10:83756644-83773527 (+)
DBA/2J	MGP_DBA2J_G0017237	protein coding gene	Chr10:74481559-74498857 (+)
FVB/NJ	MGP_FVBNJ_G0017229	protein coding gene	Chr10:73655992-73672117 (+)
LP/J	MGP_LPJ_G0017310	protein coding gene	Chr10:78381751-78400712 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017258	protein coding gene	Chr10:85791307-85811063 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017833	protein coding gene	Chr10:77289034-77305879 (+)
PWK/PhJ	MGP_PWKPhJ_G0016514	protein coding gene	Chr10:74360813-74378317 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016297	protein coding gene	Chr10:76548533-76565580 (+)
WSB/EiJ	MGP_WSBEiJ_G0016793	protein coding gene	Chr10:77266789-77285701 (+)

Human Ortholog

PTTG1IP, PTTG1 interacting protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTTG1IP, PTTG1 interacting protein
Synonyms

C21orf1, C21orf3, PBF, PTTG1IP1
Links

HGNC:13524

NCBI Gene ID: 754

UniProt: P53801
Chr Location

21q22.3; chr21:44849585-44873903 (-) GRCh38

MGI Vertebrate Homology

Pttg1ip stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PTTG1IP
Gene Tree

Pttg1ip

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References

2 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

11
Targeted

6
Genomic Mutations

4 involving Pttg1ip
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

979
Tissues

154
cDNA Data

27
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pttg1ip

ZFIN pttg1ipb

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All Sequences

110
RefSeq

4
UniProt

7
CCDS

CCDS23957.1

Ensembl

ENSMUSG00000009291 (Evidence)
NCBI Gene

108705

			Length	Strain/Species	Flank
genomic	ENSMUSG00000009291	Ensembl Gene Model \| MGI Sequence Detail	17013	C57BL/6J	± kb
transcript	ENSMUST00000009435	Ensembl \| MGI Sequence Detail	2294	Not Applicable
polypeptide	ENSMUSP00000009435	Ensembl \| MGI Sequence Detail	174	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013487 pituitary tumor-transforming gene 1 protein-interacting protein

(term hierarchy)
InterPro Domains

IPR052304 Pituitary tumor-transforming gene 1 protein-interacting

IPR016201 PSI domain
GlyGen

Q8R143 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 30

cDNA 27

Primer pair 2

Other 1

Microarray probesets 5

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MGI:1916311, MGI:2143562, MGI:2143728, MGI:2143927

Summaries

All 73

Developmental Gene Expression 5

Diseases 2

Gene Ontology 5

Phenotypes 42
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;

TSS for Pttg1ip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94260	Chr10:77417158-77417169 (+)	-390 bp
Tssr94261	Chr10:77417564-77417575 (+)	16 bp
Tssr94262	Chr10:77417579-77417603 (+)	37 bp
Tssr94263	Chr10:77417608-77417634 (+)	67 bp
Tssr94264	Chr10:77418221-77418265 (+)	689 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24