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Pttg1ip Gene Detail
Summary
  • Symbol
    Pttg1ip
  • Name
    pituitary tumor-transforming 1 interacting protein
  • Synonyms
    1810010L20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652132
    NCBI Gene: 108705
  • Gene Overview
    MyGene.info: PTTG1IP
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:77581720-77598732 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652132
protein coding gene Chr10:77581655-77598732 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017399
protein coding gene Chr10:77916378-77934534 (+)
A/J MGP_AJ_G0017376
protein coding gene Chr10:75203446-75220675 (+)
AKR/J MGP_AKRJ_G0017337
protein coding gene Chr10:77209448-77229255 (+)
BALB/cJ MGP_BALBcJ_G0017336
protein coding gene Chr10:75398023-75415597 (+)
C3H/HeJ MGP_C3HHeJ_G0017160
protein coding gene Chr10:77296056-77312925 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017794
protein coding gene Chr10:80632874-80650057 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015484
protein coding gene Chr10:71634528-71652164 (+)
CAST/EiJ MGP_CASTEiJ_G0016730
protein coding gene Chr10:77652281-77669361 (+)
CBA/J MGP_CBAJ_G0017132
protein coding gene Chr10:83756644-83773527 (+)
DBA/2J MGP_DBA2J_G0017237
protein coding gene Chr10:74481559-74498857 (+)
FVB/NJ MGP_FVBNJ_G0017229
protein coding gene Chr10:73655992-73672117 (+)
LP/J MGP_LPJ_G0017310
protein coding gene Chr10:78381751-78400712 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017258
protein coding gene Chr10:85791307-85811063 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017833
protein coding gene Chr10:77289034-77305879 (+)
PWK/PhJ MGP_PWKPhJ_G0016514
protein coding gene Chr10:74360813-74378317 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016297
protein coding gene Chr10:76548533-76565580 (+)
WSB/EiJ MGP_WSBEiJ_G0016793
protein coding gene Chr10:77266789-77285701 (+)



Homology
more
  • Human Ortholog
    PTTG1IP, PTTG1 interacting protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PTTG1IP, PTTG1 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C21orf1, C21orf3, PBF
  • Links
    NCBI Gene ID: 754
    neXtProt AC: NX_P53801
    UniProt: P53801

  • Chr Location
    21q22.3; chr21:44849585-44873903 (-)  GRCh38.p7

Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000009291 Ensembl Gene Model | MGI Sequence Detail 17013 C57BL/6J ±  kb
    transcript ENSMUST00000009435 Ensembl | MGI Sequence Detail 2294 Not Applicable  
    polypeptide ENSMUSP00000009435 Ensembl | MGI Sequence Detail 174 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013487 pituitary tumor-transforming gene 1 protein-interacting protein
    • InterPro Domains
      IPR042492 Pituitary tumor-transforming gene 1 protein-interacting protein
      IPR016201 PSI domain
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 27
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1916311, MGI:2143562, MGI:2143728, MGI:2143927
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 4
      Diseases 2
      Gene Ontology 4
      Phenotypes 30
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:300601 Tuttle KD, et al., JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome. Cell Rep. 2020 Nov 17;33(7):108407

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    02/16/2021
    MGI 6.16
    The Jackson Laboratory