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Pttg1ip Gene Detail
Summary
  • Symbol
    Pttg1ip
  • Name
    pituitary tumor-transforming 1 interacting protein
  • Synonyms
    1810010L20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2652132
    NCBI Gene: 108705
  • Gene Overview
    MyGene.info: PTTG1IP
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:77581767-77598732 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2652132
 protein coding gene Chr10:77581720-77598732 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017399
 protein coding gene Chr10:77916378-77934534 (+)
A/J MGP_AJ_G0017376
 protein coding gene Chr10:75203446-75220675 (+)
AKR/J MGP_AKRJ_G0017337
 protein coding gene Chr10:77209448-77229255 (+)
BALB/cJ MGP_BALBcJ_G0017336
 protein coding gene Chr10:75398023-75415597 (+)
C3H/HeJ MGP_C3HHeJ_G0017160
 protein coding gene Chr10:77296056-77312925 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017794
 protein coding gene Chr10:80632874-80650057 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015484
 protein coding gene Chr10:71634528-71652164 (+)
CAST/EiJ MGP_CASTEiJ_G0016730
 protein coding gene Chr10:77652281-77669361 (+)
CBA/J MGP_CBAJ_G0017132
 protein coding gene Chr10:83756644-83773527 (+)
DBA/2J MGP_DBA2J_G0017237
 protein coding gene Chr10:74481559-74498857 (+)
FVB/NJ MGP_FVBNJ_G0017229
 protein coding gene Chr10:73655992-73672117 (+)
LP/J MGP_LPJ_G0017310
 protein coding gene Chr10:78381751-78400712 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017258
 protein coding gene Chr10:85791307-85811063 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017833
 protein coding gene Chr10:77289034-77305879 (+)
PWK/PhJ MGP_PWKPhJ_G0016514
 protein coding gene Chr10:74360813-74378317 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016297
 protein coding gene Chr10:76548533-76565580 (+)
WSB/EiJ MGP_WSBEiJ_G0016793
 protein coding gene Chr10:77266789-77285701 (+)



Homology
more
  • Human Ortholog
    PTTG1IP, PTTG1 interacting protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PTTG1IP, PTTG1 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C21orf1, C21orf3, PBF
  • Links
    NCBI Gene ID: 754
    neXtProt AC: NX_P53801
    UniProt: P53801

  • Chr Location
    21q22.3; chr21:44849585-44873903 (-)  GRCh38.p7
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotype references
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    11
  • Targeted
    6
  • Genomic Mutations
    4 involving Pttg1ip
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    8 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    270
  • Tissues
    153
  • cDNA Data
    27
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 108705 NCBI Gene Model | MGI Sequence Detail 16966 C57BL/6J ±  kb
transcript NM_145925 RefSeq | MGI Sequence Detail 2375 C57BL/6  
polypeptide Q8R143 UniProt | EBI | MGI Sequence Detail 174 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 27
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1916311, MGI:2143562, MGI:2143728, MGI:2143927
References
more
  • Summaries
    All 55
    Developmental Gene Expression 4
    Diseases 2
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/06/2018
MGI 6.13 		The Jackson Laboratory