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Socs7 Gene Detail
Summary
  • Symbol
    Socs7
  • Name
    suppressor of cytokine signaling 7
  • Synonyms
    2310063P06Rik, Nap4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2651588
    NCBI Gene: 192157
  • Gene Overview
    MyGene.info: SOCS7
Location & Maps
more
  • Sequence Map
    Chr11:97362551-97398542 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35992 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 60.96 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SOCS7, suppressor of cytokine signaling 7
  • Vertebrate Orthologs
    12
  • Human Ortholog
    SOCS7, suppressor of cytokine signaling 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NAP4, NCKAP4
  • Links
    NCBI Gene ID: 30837
    neXtProt AC: NX_O14512

  • Chr Location
    17q12; chr17:38352124-38405593 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 5 alleles in 7 genetic backgrounds
    2 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Gene trapped
    4
  • Targeted
    10
  • Genomic Mutations
    1 involving Socs7
Homozygous null mice display partial penetrance of hydroencephaly, premature death, intracranial hemorrhage, abnormally large islets of Langerhans and fully penetrant disorganization of the subcommissural organ and reduced body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase socs7
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002672 VEGA Gene Model | MGI Sequence Detail 35992 C57BL/6J ±  kb
transcript OTTMUST00000005239 VEGA | MGI Sequence Detail 7015 Not Applicable  
polypeptide OTTMUSP00000002486 VEGA | MGI Sequence Detail 579 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    127 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    cDNA 11

    Microarray probesets 8
Other
Accession IDs
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MGI:1916926, MGI:2144676
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 18
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:213427 Adissu HA, et al., Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis Model Mech. 2014 May;7(5):515-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory