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Socs7
Gene Detail
Symbol

Name
ID
Socs7
suppressor of cytokine signaling 7
MGI:2651588
Synonyms
2310063P06Rik, Nap4
Feature Type
protein coding gene
Genetic Map
Chromosome 11
60.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:97362551-97398542 bp, + strand
From VEGA annotation of GRCm38

  35992 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16331  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: suppressor of cytokine signaling (SOCS) 4-7
Gene Tree: Socs7

Human
homologs
Human Homolog SOCS7, suppressor of cytokine signaling 7
NCBI Gene ID 30837
neXtProt AC  NX_O14512
Human Synonyms  NAP4, NCKAP4
Human Chr (Location)  17q12; chr17:38352124-38405593 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(4) Targeted(9)
 
Homozygous null mice display partial penetrance of hydroencephaly, premature death, intracranial hemorrhage, abnormally large islets of Langerhans and fully penetrant disorganization of the subcommissural organ and reduced body weight.
 
Phenotype Images(2)
Interactions
Socs7 interacts with 463 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cerebral cortex radially oriented cell migration, fat cell differentiation, ...
Component cytoplasm, intracellular membrane-bounded organelle, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(9)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000002672 (Evidence)
Ensembl Gene ModelENSMUSG00000038485 (Evidence)
Entrez Gene192157 (Evidence)
DFCITC1586085, TC1615467
DoTSDT.55281485
NIA Mouse Gene IndexU013270
Consensus CDS ProjectCCDS25319.1
International Mouse Knockout Project StatusSocs7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002672 VEGA Gene Model | MGI Sequence Detail 35992 C57BL/6J ±  kb
transcript OTTMUST00000005239 VEGA | MGI Sequence Detail 7015 Not Applicable 
polypeptide OTTMUSP00000002486 VEGA | MGI Sequence Detail 579 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(9) UniProt(1)
Polymorphisms
SNPs within 2kb(128 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
InterPro IPR001496 SOCS protein, C-terminal
Protein Ontology PR:000015398 suppressor of cytokine signaling 7
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:205551 Simo S, et al., Rbx2 regulates neuronal migration through different cullin 5-RING ligase adaptors. Dev Cell. 2013 Nov 25;27(4):399-411
All references(38)
Other
accession IDs
MGI:1916926, MGI:2144676

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory