Bai2
Gene Detail

Symbol Name ID

Bai2 brain-specific angiogenesis inhibitor 2 MGI:2451244

Feature Type

protein coding gene

Genetic Map

Chromosome 4

63.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:129984870-130022633 bp, + strand From VEGA annotation of GRCm38   37764 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Bai2 ± 2 cM)

Protein SuperFamily: brain-specific angiogenesis inhibitor
Gene Tree: Bai2

Human ortholog

BAI2 brain-specific angiogenesis inhibitor 2 NCBI Gene ID 576
Human Chr1:32192718-32229648 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene show a lessening of depression like behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cell surface receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (137)    Tissues (96)    Images (71)
Theiler Stages: 11, 26, 28

Assay Type	Results
In situ reporter (knock in)	89
Northern blot	9
RT-PCR	39

cDNA source data(56)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) cDNA(56) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009519 (Evidence)
Ensembl Gene Model	ENSMUSG00000028782 (Evidence)
Entrez Gene	230775 (Evidence)
UniGene	262241
DFCI	TC1579874, TC1596617
Consensus CDS Project	CCDS51309.1, CCDS57300.1
International Mouse Knockout Project Status	Bai2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009519	VEGA Gene Model | MGI Sequence Detail	37764	C57BL/6J
transcript	OTTMUST00000090352	VEGA | MGI Sequence Detail	4734	Not Applicable
polypeptide	OTTMUSP00000049547	VEGA | MGI Sequence Detail	1577	Not Applicable

All sequences(68) RefSeq(4) UniProt(7)

Polymorphisms

SNPs(136 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022624	Domain of unknown function DUF3497
InterPro	IPR008077	GPCR, family 2, brain-specific angiogenesis inhibitor
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR000203	GPS domain
InterPro	IPR000884	Thrombospondin, type 1 repeat
Protein Ontology	PR:000004630	brain-specific angiogenesis inhibitor 2

References

(Earliest) J:77162 Kee HJ, et al., Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. J Cereb Blood Flow Metab. 2002 Sep;22(9):1054-67
(Latest) J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
All references(26)