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Adgrb2 Gene Detail
Summary
  • Symbol
    Adgrb2
  • Name
    adhesion G protein-coupled receptor B2
  • Synonyms
    Bai2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2451244
    NCBI Gene: 230775
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129984870-130022633 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    262 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2451244
protein coding gene Chr4:129984870-130022633 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028841
protein coding gene Chr4:131963234-132003813 (+)
A/J MGP_AJ_G0028800
protein coding gene Chr4:126672530-126711035 (+)
AKR/J MGP_AKRJ_G0028753
protein coding gene Chr4:130217004-130259446 (+)
BALB/cJ MGP_BALBcJ_G0028823
protein coding gene Chr4:127282066-127321132 (+)
C3H/HeJ MGP_C3HHeJ_G0028537
protein coding gene Chr4:130276494-130314843 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029265
protein coding gene Chr4:136910490-136957506 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026537
protein coding gene Chr4:119797800-119835340 (+)
CAST/EiJ MGP_CASTEiJ_G0027969
protein coding gene Chr4:128470362-128513025 (+)
CBA/J MGP_CBAJ_G0028503
protein coding gene Chr4:140383959-140427333 (+)
DBA/2J MGP_DBA2J_G0028652
protein coding gene Chr4:127107495-127145045 (+)
FVB/NJ MGP_FVBNJ_G0028619
protein coding gene Chr4:125890600-125931269 (+)
LP/J MGP_LPJ_G0028753
protein coding gene Chr4:132287053-132326776 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028645
protein coding gene Chr4:145100874-145140982 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029303
protein coding gene Chr4:130584863-130625159 (+)
PWK/PhJ MGP_PWKPhJ_G0027691
protein coding gene Chr4:123719561-123758220 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027517
protein coding gene Chr4:126465625-126507936 (+)
WSB/EiJ MGP_WSBEiJ_G0028050
protein coding gene Chr4:130726207-130767869 (+)



Homology
more
  • Human Ortholog
    ADGRB2, adhesion G protein-coupled receptor B2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADGRB2, adhesion G protein-coupled receptor B2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BAI2
  • Links
    NCBI Gene ID: 576
    neXtProt AC: NX_O60241
    UniProt: O60241

  • Chr Location
    1p35.2; chr1:31727105-31764063 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene show a lessening of depression like behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 230775 NCBI Gene Model | MGI Sequence Detail 37764 C57BL/6J ±  kb
transcript NM_173071 RefSeq | MGI Sequence Detail 5241 C57BL/6  
polypeptide Q8CGM1 UniProt | EBI | MGI Sequence Detail 1561 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR032471 GAIN domain, N-terminal
    IPR008077 GPCR, family 2, brain-specific angiogenesis inhibitor
    IPR001879 GPCR, family 2, extracellular hormone receptor domain
    IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
    IPR017981 GPCR, family 2-like
    IPR000832 GPCR, family 2, secretin-like
    IPR000203 GPS motif
    IPR000884 Thrombospondin type-1 (TSP1) repeat
    IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
Molecular
Reagents
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  • All nucleic 59
    cDNA 57
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:77162 Kee HJ, et al., Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. J Cereb Blood Flow Metab. 2002 Sep;22(9):1054-67
  • Latest
    J:250129 Speca DJ, et al., Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. Mamm Genome. 2017 Dec;28(11-12):465-475

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory