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Bai2
Gene Detail
 Symbol
Name
ID
Bai2
brain-specific angiogenesis inhibitor 2
MGI:2451244
Feature Type protein coding gene
Genetic Map
Chromosome 4
63.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:129984870-130022633 bp, + strand
From VEGA annotation of GRCm38

  37764 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1288  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: brain-specific angiogenesis inhibitor
Gene Tree: Bai2

Human
homologs
Human Homolog BAI2, brain-specific angiogenesis inhibitor 2
NCBI Gene ID 576
neXtProt AC  NX_O60241
Human Chr (Location)  1p35; chr1:31727111-31764047 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene show a lessening of depression like behavior.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell surface receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (137)    Tissues (96)    Images (71)
Theiler Stages: 11, 26, 28
Assay TypeResults
In situ reporter (knock in) 89
Northern blot 9
RT-PCR 39
cDNA source data(56)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(58) cDNA(56) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009519 (Evidence)
Ensembl Gene ModelENSMUSG00000028782 (Evidence)
Entrez Gene230775 (Evidence)
UniGene262241
DFCITC1579874, TC1596617
Consensus CDS ProjectCCDS51309.1, CCDS57300.1, CCDS71478.1
International Mouse Knockout Project StatusBai2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009519 VEGA Gene Model | MGI Sequence Detail 37764 C57BL/6J ±  kb
transcript OTTMUST00000090352 VEGA | MGI Sequence Detail 4734 Not Applicable 
polypeptide OTTMUSP00000049547 VEGA | MGI Sequence Detail 1577 Not Applicable 

For the selected sequences
All sequences(112) RefSeq(48) UniProt(7)
Polymorphisms SNPs within 2kb(267 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022624 Domain of unknown function DUF3497
InterPro IPR008077 GPCR, family 2, brain-specific angiogenesis inhibitor
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000203 GPS domain
InterPro IPR000884 Thrombospondin, type 1 repeat
Protein Ontology PR:000004630 brain-specific angiogenesis inhibitor 2
References (Earliest) J:77162 Kee HJ, et al., Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. J Cereb Blood Flow Metab. 2002 Sep;22(9):1054-67
(Latest) J:165751 Du J, et al., O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory