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Xylt1
Gene Detail
Symbol

Name
ID
Xylt1
xylosyltransferase 1
MGI:2451073
Feature Type
protein coding gene
Genetic Map
Chromosome 7
62.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:117380979-117667751 bp, + strand
From VEGA annotation of GRCm38

  286773 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32534  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Xylt1

Human
homologs
Human Homolog XYLT1, xylosyltransferase I
NCBI Gene ID 64131
neXtProt AC  NX_Q86Y38
Human Synonyms  DBQD2, PXYLT1, XT1, XTI, XT-I, XYLTI
Human Chr (Location)  16p12.3; chr16:17102324-17470881 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human XYLT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Chemically induced (ENU)(1) Gene trapped(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for an ENU-induced allele exhibit partial preweaning lethality, impaired chondrocyte maturation and decreased skeletal length.
 
Interactions
Xylt1 interacts with 24 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (26)    Tissues (3)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 26
cDNA source data(2)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(2) Primer pair(1) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000032722 (Evidence)
Ensembl Gene ModelENSMUSG00000030657 (Evidence)
Entrez Gene233781 (Evidence)
UniGene461427
DFCITC1589153, TC1629763
DoTSDT.101300429, DT.101275505, DT.91294456
NIA Mouse Gene IndexU008673
EC2.4.2.26
Consensus CDS ProjectCCDS40101.1
International Mouse Knockout Project StatusXylt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032722 VEGA Gene Model | MGI Sequence Detail 286773 C57BL/6J ±  kb
transcript OTTMUST00000081402 VEGA | MGI Sequence Detail 3191 Not Applicable 
polypeptide OTTMUSP00000043549 VEGA | MGI Sequence Detail 953 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(2323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003406 Glycosyl transferase, family 14
InterPro IPR024448 Xylosyltransferase
Protein Ontology PR:000017515 xylosyltransferase 1
References
(Earliest) J:66285 Gotting C, et al., Molecular cloning and expression of human UDP-d-Xylose:Proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II. J Mol Biol. 2000 Dec 8;304(4):517-28
(Latest) J:205339 Mis EK, et al., Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Dev Biol. 2014 Jan 1;385(1):67-82
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory