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Pilrb1
Gene Detail
 Symbol
Name
ID
Pilrb1
paired immunoglobin-like type 2 receptor beta 1
MGI:2450532
Synonyms Fdact, Pilrb
Feature Type protein coding gene
Genetic Map
Chromosome 5
76.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:137852147-137858049 bp, - strand
From NCBI annotation of GRCm38

  5903 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:114502  Vertebrate Homology Class
1 human; 2 mouse; 18 rat; 1 chimpanzee; 1 rhesus macaque

Gene Tree: Pilrb1

Human
homologs
Human Homolog PILRB, paired immunoglobin-like type 2 receptor beta
NCBI Gene ID 29990
neXtProt AC  NX_Q9UKJ0
Human Synonyms  FDFACT1, FDFACT2
Human Chr (Location)  7q22.1; chr7:100358003-100367831 (+)  GRCh38
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased susceptiblity to bacterial infection with S. aureus with decreased worm burden and mortality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process myeloid dendritic cell activation, negative regulation of osteoclast differentiation
Component integral component of membrane, membrane, ...
Function MHC class I protein binding, protein binding
External Resources: FuncBase
Expression
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000066684 (Evidence)
Entrez Gene170741 (Evidence)
UniGene347593
DoTSDT.101376067
Consensus CDS ProjectCCDS51675.1
International Mouse Knockout Project StatusPilrb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 170741 NCBI Gene Model | MGI Sequence Detail 5903 C57BL/6J ±  kb
transcript NM_133209 RefSeq | MGI Sequence Detail 1020 C57BL/6 
polypeptide Q2YFS2 UniProt | EBI | MGI Sequence Detail 224 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(5) UniProt(2)
Polymorphisms SNPs within 2kb(19 from dbSNP Build 137)    SNPs within 2kb including multiple locations(45)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000012731 paired immunoglobulin-like type 2 receptor beta
Graphical View of Protein Domain Structure
References (Earliest) J:77738 Fournier N, et al., FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J Immunol. 2000 Aug 1;165(3):1197-209
(Latest) J:187128 Tato CM, et al., The myeloid receptor PILRbeta mediates the balance of inflammatory responses through regulation of IL-27 production. PLoS One. 2012;7(3):e31680
All references(23)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory