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Pilrb1 Gene Detail
Summary
  • Symbol
    Pilrb1
  • Name
    paired immunoglobin-like type 2 receptor beta 1
  • Synonyms
    Fdact, Pilrb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450532
    NCBI Gene: 170741
  • Gene Overview
    MyGene.info: PILRB
Location & Maps
more
  • Sequence Map
    Chr5:137852147-137858106 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5960 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.82 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PILRB, paired immunoglobin-like type 2 receptor beta
  • Vertebrate Orthologs
    23
  • Human Ortholog
    PILRB, paired immunoglobin-like type 2 receptor beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FDFACT1, FDFACT2
  • Links
    NCBI Gene ID: 29990
    neXtProt AC: NX_Q9UKJ0

  • Chr Location
    7q22.1; chr7:100358003-100367831 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptiblity to bacterial infection with S. aureus with decreased worm burden and mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054648 VEGA Gene Model | MGI Sequence Detail 5960 C57BL/6J ±  kb
transcript OTTMUST00000135490 VEGA | MGI Sequence Detail 1807 Not Applicable  
polypeptide OTTMUSP00000071692 VEGA | MGI Sequence Detail 225 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    6 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
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  • All nucleic 4
    cDNA 4

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:77738 Fournier N, et al., FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J Immunol. 2000 Aug 1;165(3):1197-209
  • Latest
    J:187128 Tato CM, et al., The myeloid receptor PILRbeta mediates the balance of inflammatory responses through regulation of IL-27 production. PLoS One. 2012;7(3):e31680

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory