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Pilrb1 Gene Detail
Summary
  • Symbol
    Pilrb1
  • Name
    paired immunoglobin-like type 2 receptor beta 1
  • Synonyms
    Fdact, Pilrb
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450532
    NCBI Gene: 170741
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137850409-137856368 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.82 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450532
protein coding gene Chr5:137850403-137856687 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0030678
protein coding gene Chr5:147891965-147933900 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027895
protein coding gene Chr5:130646418-130655202 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0029912
protein coding gene Chr5:153836479-153857477 (-)
DBA/2J MGP_DBA2J_G0030062
protein coding gene Chr5:136327210-136380793 (-)
FVB/NJ MGP_FVBNJ_G0030017
protein coding gene Chr5:135520527-135541131 (-)
LP/J MGP_LPJ_G0030152
protein coding gene Chr5:143162214-143171260 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030050
protein coding gene Chr5:156647843-156661375 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030718
protein coding gene Chr5:140717219-140724853 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0028900
protein coding gene Chr5:138270985-138272087 (+)
WSB/EiJ MGP_WSBEiJ_G0029424
protein coding gene Chr5:141450933-141456853 (-)



Homology
more
  • Human Ortholog
    PILRA, paired immunoglobin like type 2 receptor alpha
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PILRA, paired immunoglobin like type 2 receptor alpha
  • Synonyms
    FDF03
  • Links
    NCBI Gene ID: 29992
    neXtProt AC: NX_Q9UKJ1
    UniProt: Q9UKJ1

  • Chr Location
    7q22.1; chr7:100373445-100400099 (+)  GRCh38.p7

  • Human Ortholog
    PILRB, paired immunoglobin like type 2 receptor beta
  • Synonyms
    FDFACT1, FDFACT2
  • Links
    NCBI Gene ID: 29990
    neXtProt AC: NX_Q9UKJ0
    UniProt: Q9UKJ0

  • Chr Location
    7q22.1; chr7:100358003-100367831 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptiblity to bacterial infection with S. aureus with decreased worm burden and mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000066684 Ensembl Gene Model | MGI Sequence Detail 5960 C57BL/6J ±  kb
    transcript ENSMUST00000199387 Ensembl | MGI Sequence Detail 1807 Not Applicable  
    polypeptide ENSMUSP00000143379 Ensembl | MGI Sequence Detail 225 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 2
    References
    more
    • Summaries
      All 23
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:77738 Fournier N, et al., FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J Immunol. 2000 Aug 1;165(3):1197-209
    • Latest
      J:286045 Li YT, et al., Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-beta1 and PILR-alpha. Elife. 2019 Aug 6;8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/12/2021
    MGI 6.17
    The Jackson Laboratory