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Pilra
Gene Detail
 Symbol
Name
ID
Pilra
paired immunoglobin-like type 2 receptor alpha
MGI:2450529
Synonyms FDF03
Feature Type protein coding gene
Genetic Map
Chromosome 5
76.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:137821952-137836268 bp, - strand
From VEGA annotation of GRCm38

  14317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8387  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 2 cattle; 2 dog

Gene Tree: Pilra

Human
homologs
Human Homolog PILRA, paired immunoglobin-like type 2 receptor alpha
NCBI Gene ID 29992
neXtProt AC  NX_Q9UKJ1
Human Synonyms  FDF03
Human Chr (Location)  7q22.1; chr7:100367535-100400099 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased increased alanine transferase, blood urea nitrogen, lactate dehydrogenase, neutrophils and mortality and altered liver morphology (massive hemorrhage, disorganized hepatic cords and karyolysis of hepatocytes) following treatment with LPS.
 
Interactions
Pilra interacts with 198 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process signal transduction
Component extracellular vesicular exosome, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)    Images (1)
Theiler Stages: 23
Assay TypeResults
RNA in situ 3
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022871 (Evidence)
Ensembl Gene ModelENSMUSG00000046245 (Evidence)
Entrez Gene231805 (Evidence)
UniGene379385
DoTSDT.101174644, DT.40161914, DT.97406221
Consensus CDS ProjectCCDS19780.1
International Mouse Knockout Project StatusPilra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022871 VEGA Gene Model | MGI Sequence Detail 14317 C57BL/6J ±  kb
transcript OTTMUST00000054987 VEGA | MGI Sequence Detail 2578 Not Applicable 
polypeptide OTTMUSP00000026272 VEGA | MGI Sequence Detail 302 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(30 from dbSNP Build 137)    SNPs within 2kb including multiple locations(32)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000012730 paired immunoglobulin-like type 2 receptor alpha
References (Earliest) J:77738 Fournier N, et al., FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J Immunol. 2000 Aug 1;165(3):1197-209
(Latest) J:191085 Wang J, et al., Neutrophil infiltration during inflammation is regulated by PILRalpha via modulation of integrin activation. Nat Immunol. 2013 Jan;14(1):34-40
All references(31)
Other
accession IDs
MGI:2141104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory