About   Help   FAQ
Pilra
Gene Detail
Symbol

Name
ID
Pilra
paired immunoglobin-like type 2 receptor alpha
MGI:2450529
Synonyms
FDF03
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:137821952-137836268 bp, - strand
From VEGA annotation of GRCm38

  14317 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8387  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 2 cattle; 2 dog

HCOP human homology predictions: PILRA
Gene Tree: Pilra

Human
homologs
PILRA, paired immunoglobin-like type 2 receptor alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 29992
neXtProt AC: NX_Q9UKJ1

Human Synonyms: FDF03

Human Chr (Location): 7q22.1; chr7:100373445-100400099 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased increased alanine transferase, blood urea nitrogen, lactate dehydrogenase, neutrophils and mortality and altered liver morphology (massive hemorrhage, disorganized hepatic cords and karyolysis of hepatocytes) following treatment with LPS.
 
Interactions
Pilra interacts with 197 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process signal transduction
Component extracellular exosome, integral component of membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 3
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022871 (Evidence)
Ensembl Gene Model ENSMUSG00000046245 (Evidence)
Entrez Gene 231805 (Evidence)
UniGene 379385
DoTS DT.101174644, DT.97406221, DT.40161914
Consensus CDS Project CCDS19780.1
International Mouse Phenotyping Consortium Status Pilra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022871 VEGA Gene Model | MGI Sequence Detail 14317 C57BL/6J ±  kb
transcript OTTMUST00000054987 VEGA | MGI Sequence Detail 2578 Not Applicable 
polypeptide OTTMUSP00000026272 VEGA | MGI Sequence Detail 302 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)    SNPs within 2kb including multiple locations(32)
Protein-related
information
ResourceIDDescription
InterPro IPR013783 Immunoglobulin-like fold
Protein Ontology PR:000012730 paired immunoglobulin-like type 2 receptor alpha
References
(Earliest) J:77738 Fournier N, et al., FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J Immunol. 2000 Aug 1;165(3):1197-209
(Latest) J:191085 Wang J, et al., Neutrophil infiltration during inflammation is regulated by PILRalpha via modulation of integrin activation. Nat Immunol. 2013 Jan;14(1):34-40
All references(29)
Other
accession IDs
MGI:2141104

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory