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Pilra Gene Detail
Summary
  • Symbol
    Pilra
  • Name
    paired immunoglobin-like type 2 receptor alpha
  • Synonyms
    FDF03
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450529
    NCBI Gene: 231805
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137821952-137836278 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.77 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450529
protein coding gene Chr5:137821952-137836281 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0030224
protein coding gene Chr5:137791631-137805252 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0030676
protein coding gene Chr5:147880521-147912228 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027894
protein coding gene Chr5:130627756-130639756 (-)
CAST/EiJ MGP_CASTEiJ_G0029350
protein coding gene Chr5:140890215-140905825 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0030061
protein coding gene Chr5:136304881-136381491 (-)
FVB/NJ MGP_FVBNJ_G0030016
protein coding gene Chr5:135497693-135541131 (-)
LP/J MGP_LPJ_G0030150
protein coding gene Chr5:143101870-143111674 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030048
protein coding gene Chr5:156586970-156661419 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030717
protein coding gene Chr5:140681042-140724910 (-)
PWK/PhJ MGP_PWKPhJ_G0029063
protein coding gene Chr5:135384000-135396868 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028899
protein coding gene Chr5:138247185-138264939 (-)
WSB/EiJ MGP_WSBEiJ_G0029423
protein coding gene Chr5:141415877-141446771 (-)



Homology
more
  • Human Ortholog
    PILRA, paired immunoglobin like type 2 receptor alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PILRA, paired immunoglobin like type 2 receptor alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FDF03
  • Links
    NCBI Gene ID: 29992
    neXtProt AC: NX_Q9UKJ1
    UniProt: Q9UKJ1

  • Chr Location
    7q22.1; chr7:100373445-100400099 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased increased alanine transferase, blood urea nitrogen, lactate dehydrogenase, neutrophils and mortality and altered liver morphology (massive hemorrhage, disorganized hepatic cords and karyolysis of hepatocytes) following treatment with LPS.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 231805 NCBI Gene Model | MGI Sequence Detail 14327 C57BL/6J ±  kb
    transcript NM_153510 RefSeq | MGI Sequence Detail 2588 C57BL/6  
    polypeptide Q2YFS3 UniProt | EBI | MGI Sequence Detail 302 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141104
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:77738 Fournier N, et al., FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells. J Immunol. 2000 Aug 1;165(3):1197-209
    • Latest
      J:246179 Kohyama M, et al., Monocyte infiltration into obese and fibrilized tissues is regulated by PILRalpha. Eur J Immunol. 2016 May;46(5):1214-23

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory