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Prss27
Gene Detail
 Symbol
Name
ID
Prss27
protease, serine 27
MGI:2450123
Synonyms CAPH2, marapsin, Mpn, Pancreasin
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.21 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:24038144-24045954 bp, + strand
From VEGA annotation of GRCm38

  7811 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 western clawed frog; 2 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Prss27

Human
homologs
Human Homolog PRSS27, protease, serine 27
NCBI Gene ID 83886
neXtProt AC  NX_Q9BQR3
Human Synonyms  CAPH2, MPN
Human Chr (Location)  chr16:2712422-2720551 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a gene trap allele develop normally and are fertile.
 
Interactions
Prss27 interacts with 29 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process proteolysis
Component extracellular region, plasma membrane
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (20)    Tissues (20)    Images (1)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RT-PCR 20
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000023861 (Evidence)
Ensembl Gene ModelENSMUSG00000050762 (Evidence)
Entrez Gene213171 (Evidence)
UniGene133083
DFCITC1590360
DoTSDT.55141178
NIA Mouse Gene IndexU017630
EC3.4.21.-
Consensus CDS ProjectCCDS28472.1
International Mouse Knockout Project StatusPrss27
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023861 VEGA Gene Model | MGI Sequence Detail 7811 C57BL/6J ±  kb
transcript OTTMUST00000058290 VEGA | MGI Sequence Detail 1253 Not Applicable 
polypeptide OTTMUSP00000028216 VEGA | MGI Sequence Detail 328 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013324 serine protease 27
References (Earliest) J:81493 Bhagwandin VJ, et al., Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. J Biol Chem. 2003 Jan 31;278(5):3363-71
(Latest) J:203504 Raman K, et al., Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. J Biol Chem. 2013 Apr 12;288(15):10588-98
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory