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Prss27 Gene Detail
Summary
  • Symbol
    Prss27
  • Name
    protease, serine 27
  • Synonyms
    CAPH2, marapsin, Mpn, Pancreasin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450123
    NCBI Gene: 213171
Location & Maps
more
  • Sequence Map
    Chr17:24038144-24045954 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7811 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.21 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRSS27, protease, serine 27
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRSS27, protease, serine 27
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAPH2, MPN
  • Links
    NCBI Gene ID: 83886
    neXtProt AC: NX_Q9BQR3

  • Chr Location
    chr16:2712418-2720578 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a gene trap allele develop normally and are fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023861 VEGA Gene Model | MGI Sequence Detail 7811 C57BL/6J ±  kb
transcript OTTMUST00000058290 VEGA | MGI Sequence Detail 1253 Not Applicable  
polypeptide OTTMUSP00000028216 VEGA | MGI Sequence Detail 328 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    96 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:81493 Bhagwandin VJ, et al., Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. J Biol Chem. 2003 Jan 31;278(5):3363-71
  • Latest
    J:203504 Raman K, et al., Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. J Biol Chem. 2013 Apr 12;288(15):10588-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory