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Prss27 Gene Detail
Summary
  • Symbol
    Prss27
  • Name
    protease, serine 27
  • Synonyms
    CAPH2, marapsin, Mpn, Pancreasin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450123
    NCBI Gene: 213171
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24038243-24045949 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.21 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450123
protein coding gene Chr17:24038144-24045954 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023286
protein coding gene Chr17:22988994-22996659 (+)
A/J MGP_AJ_G0023246
protein coding gene Chr17:22390948-22398606 (+)
AKR/J MGP_AKRJ_G0023213
protein coding gene Chr17:22450873-22458525 (+)
BALB/cJ MGP_BALBcJ_G0023251
protein coding gene Chr17:22566539-22574371 (+)
C3H/HeJ MGP_C3HHeJ_G0023011
protein coding gene Chr17:22782089-22789692 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023694
protein coding gene Chr17:24013127-24032140 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021171
protein coding gene Chr17:19847999-19855550 (+)
CAST/EiJ MGP_CASTEiJ_G0022513
protein coding gene Chr17:22622589-22630215 (+)
CBA/J MGP_CBAJ_G0022987
protein coding gene Chr17:24843101-24851362 (+)
DBA/2J MGP_DBA2J_G0023116
protein coding gene Chr17:21963116-21971040 (+)
FVB/NJ MGP_FVBNJ_G0023086
protein coding gene Chr17:21678349-21686012 (+)
LP/J MGP_LPJ_G0023193
protein coding gene Chr17:23303478-23311131 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023105
protein coding gene Chr17:24575601-24584588 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023732
protein coding gene Chr17:22712314-22721235 (+)
PWK/PhJ MGP_PWKPhJ_G0022262
protein coding gene Chr17:20714404-20722276 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022081
protein coding gene Chr17:20735281-20744526 (+)
WSB/EiJ MGP_WSBEiJ_G0022576
protein coding gene Chr17:22773492-22781118 (+)



Homology
more
  • Human Ortholog
    PRSS27, serine protease 27
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PRSS27, serine protease 27
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAPH2, MPN
  • Links
    NCBI Gene ID: 83886
    neXtProt AC: NX_Q9BQR3
    UniProt: Q9BQR3

  • Chr Location
    chr16:2712418-2720551 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele develop normally and are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213171 NCBI Gene Model | MGI Sequence Detail 7707 C57BL/6J ±  kb
    transcript NM_175440 RefSeq | MGI Sequence Detail 1149 C57BL/6  
    polypeptide Q8BJR6 UniProt | EBI | MGI Sequence Detail 328 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:81493 Bhagwandin VJ, et al., Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. J Biol Chem. 2003 Jan 31;278(5):3363-71
    • Latest
      J:248734 Bolt CC, et al., Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate. PLoS One. 2016;11(4):e0154413

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/24/2020
    MGI 6.15
    The Jackson Laboratory