Nox1 MGI Mouse Gene Detail - MGI:2450016

Symbol

Nox1
Name

NADPH oxidase 1
Synonyms

GP91 phox homolog, Nox-1

Feature Type

protein coding gene
IDs

MGI:2450016
NCBI Gene: 237038
Gene Overview

MyGene.info: NOX1
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrX:134086421-134137711 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 55.69 cM
Mapping Data

1 experiment

SNPs within 2kb

192 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2450016	protein coding gene	ChrX:134086421-134221956 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036061	protein coding gene	ChrX:131235657-131382779 (-)
A/J	MGP_AJ_G0036043	protein coding gene	ChrX:130658801-130807731 (-)
AKR/J	MGP_AKRJ_G0035962	protein coding gene	ChrX:134831155-135001500 (-)
BALB/cJ	MGP_BALBcJ_G0036034	protein coding gene	ChrX:129105402-129244442 (-)
C3H/HeJ	MGP_C3HHeJ_G0035738	protein coding gene	ChrX:131312531-131461759 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036556	protein coding gene	ChrX:135098657-135253930 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033384	protein coding gene	ChrX:122864052-123000657 (-)
CAST/EiJ	MGP_CASTEiJ_G0035025	protein coding gene	ChrX:112192501-112336050 (-)
CBA/J	MGP_CBAJ_G0035715	protein coding gene	ChrX:139141596-139302846 (-)
DBA/2J	MGP_DBA2J_G0035868	protein coding gene	ChrX:129997272-130134535 (-)
FVB/NJ	MGP_FVBNJ_G0035810	protein coding gene	ChrX:129307652-129454827 (-)
LP/J	MGP_LPJ_G0035961	protein coding gene	ChrX:132113405-132261929 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035838	protein coding gene	ChrX:146546766-146693587 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036585	protein coding gene	ChrX:130668313-130810266 (-)
PWK/PhJ	MGP_PWKPhJ_G0034717	protein coding gene	ChrX:109148804-109287521 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034549	protein coding gene	ChrX:112824676-112970162 (-)
WSB/EiJ	MGP_WSBEiJ_G0035162	protein coding gene	ChrX:129048389-129192333 (-)

Human Ortholog

NOX1, NADPH oxidase 1

Vertebrate Orthologs

11

Human Ortholog

NOX1, NADPH oxidase 1
Orthology source: HomoloGene, HGNC
Synonyms

GP91-2, MOX1, NOH1, NOH-1
Links

HGNC:7889

NCBI Gene ID: 27035

neXtProt AC: NX_Q9Y5S8

UniProt: Q9Y5S8
Chr Location

Xq22.1; chrX:100843324-100874345 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 48495
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NOX1
Gene Tree

Nox1

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Phenotype Summary

12 phenotypes from 3 alleles in 3 genetic backgrounds
53 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Targeted

7
Transgenic

1
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice hemizygous for one mutation show abnormal blood vessel morphology and physiology with decreased basal systolic blood pressure. Male hemizygotes for two null mutations exhibit abnormal response to angiotensin II.

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All GO Annotations

42
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1
Tissues

1
cDNA Data

2
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nox1

ZFIN nox1

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Nox1 interacts with 130 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

44
RefSeq

4
UniProt

3
CCDS

CCDS30390.1

Ensembl

ENSMUSG00000031257 (Evidence)
NCBI Gene

237038

			Length	Strain/Species	Flank
genomic	237038	NCBI Gene Model \| MGI Sequence Detail	51291	C57BL/6J	± kb
transcript	NM_172203	RefSeq \| MGI Sequence Detail	2563	Not Specified
polypeptide	Q8CIZ9	UniProt \| EBI \| MGI Sequence Detail	591	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000001824 NADPH oxidase 1

(term hierarchy)
EC

1.-.-.-
InterPro Domains

IPR000778 Cytochrome b245, heavy chain

IPR013112 FAD-binding 8

IPR017927 FAD-binding domain, ferredoxin reductase-type

IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

IPR013121 Ferric reductase, NAD binding domain

IPR013130 Ferric reductase transmembrane component-like domain

IPR029650 NADPH oxidase 1

IPR017938 Riboflavin synthase-like beta-barrel

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All nucleic 3

cDNA 2

Primer pair 1

Microarray probesets 1

Summaries

All 110

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 53
Earliest

J:81679 Banfi B, et al., Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem. 2003 Feb 7;278(6):3510-3
Latest

J:264775 Russo R, et al., Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease. Neurobiol Aging. 2018 Aug;68:123-133

TSS for Nox1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164134	ChrX:134111852-134111873 (-)	25,848 bp
Tssr164133	ChrX:134111826-134111836 (-)	25,880 bp
Tssr164132	ChrX:134111806-134111814 (-)	25,901 bp
Tssr164131	ChrX:134111766-134111788 (-)	25,934 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/06/2018 MGI 6.13