Nox1 MGI Mouse Gene Detail - MGI:2450016

Nox1 Gene Detail

Symbol

Nox1
Name

NADPH oxidase 1
Synonyms

GP91 phox homolog, Nox-1

Feature Type

protein coding gene
IDs

MGI:2450016
NCBI Gene: 237038
Gene Overview

MyGene.info: NOX1

Sequence Map

ChrX:134086421-134221956 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

135536 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 55.69 cM
Mapping Data

1 experiment

Human Ortholog

NOX1, NADPH oxidase 1

Vertebrate Orthologs

11

Human Ortholog

NOX1, NADPH oxidase 1
Orthology source: HomoloGene, HGNC
Synonyms

GP91-2, MOX1, NOH1, NOH-1
Links

HGNC:7889

NCBI Gene ID: 27035

neXtProt AC: NX_Q9Y5S8
Chr Location

Xq22; chrX:100843324-100874345 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 48495
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: NOX1
Gene Tree

Nox1

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Phenotype Summary

12 phenotypes from 3 alleles in 3 genetic backgrounds
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Targeted

5

Male mice hemizygous for one mutation show abnormal blood vessel morphology and physiology with decreased basal systolic blood pressure. Male hemizygotes for two null mutations exhibit abnormal response to angiotensin II.

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All GO Annotations

51
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1
Tissues

1
cDNA Data

1
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase nox1

ZFIN nox1

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Nox1 interacts with 130 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

39
RefSeq

4
UniProt

3
CCDS

CCDS30390.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000019159	VEGA Gene Model \| MGI Sequence Detail	135536	C57BL/6J	± kb
transcript	OTTMUST00000045925	VEGA \| MGI Sequence Detail	2563	Not Applicable
polypeptide	OTTMUSP00000020697	VEGA \| MGI Sequence Detail	563	Not Applicable

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SNPs within 2kb

428 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000001824 NADPH oxidase 1
EC

1.-.-.-
InterPro Domains

IPR000778 Cytochrome b245, heavy chain

IPR013112 FAD-binding 8

IPR017927 Ferredoxin reductase-type FAD-binding domain

IPR013121 Ferric reductase, NAD binding domain

IPR013130 Ferric reductase transmembrane component-like domain

IPR029650 NADPH oxidase 1

IPR017938 Riboflavin synthase-like beta-barrel

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All nucleic 2

cDNA 1

Primer pair 1

Microarray probesets 1

Summaries

All 71

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 42
Earliest

J:81679 Banfi B, et al., Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem. 2003 Feb 7;278(6):3510-3
Latest

J:231185 Hsieh LT, et al., Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1beta synthesis. Matrix Biol. 2016 Jan;49:61-81

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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