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Nox1 Gene Detail
Summary
  • Symbol
    Nox1
  • Name
    NADPH oxidase 1
  • Synonyms
    GP91 phox homolog, Nox-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450016
    NCBI Gene: 237038
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:132987170-133038455 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 55.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1072 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450016
 protein coding gene ChrX:132987170-133122705 (-)
129S1/SvImJ ENSMUSG00200011030
 protein coding gene ChrX:112037620-112088929 (-)
A/J ENSMUSG00195045274
 protein coding gene ChrX:115905244-115956557 (-)
AKR/J ENSMUSG00220012753
 protein coding gene ChrX:109516430-109567739 (-)
BALB/cJ ENSMUSG00180018393
 protein coding gene ChrX:112323408-112374718 (-)
C3H/HeJ ENSMUSG00175029662
 protein coding gene ChrX:116171791-116223088 (-)
C57BL/6NJ ENSMUSG00215042874
 protein coding gene ChrX:112693074-112744371 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033384
 protein coding gene ChrX:122864052-123000657 (-)
CAST/EiJ ENSTCUG00005038689
 protein coding gene ChrX:113500942-113552208 (-)
CBA/J ENSMUSG00210034759
 protein coding gene ChrX:113073409-113124718 (-)
DBA/2J ENSMUSG00185028729
 protein coding gene ChrX:126997869-127049173 (-)
FVB/NJ ENSMUSG00205011794
 protein coding gene ChrX:111701561-111752867 (-)
JF1/MsJ ENSUMUG00000015335
 protein coding gene ChrX:146156478-146207678 (-)
LP/J ENSMUSG00230039452
 protein coding gene ChrX:133686580-133737882 (-)
NOD/ShiLtJ ENSMUSG00190027599
 protein coding gene ChrX:112509345-112560637 (-)
NZO/HlLtJ ENSMUSG00225036848
 protein coding gene ChrX:138348023-138399167 (-)
PWK/PhJ ENSLUMG00010008901
 protein coding gene ChrX:110825469-110876816 (-)
SPRET/EiJ ENSMSPG00010037455
 protein coding gene ChrX:115670535-115721113 (-)
WSB/EiJ ENSIUOG00005034885
 protein coding gene ChrX:113248764-113300093 (-)



Homology
more
  • Human Ortholog
    NOX1, NADPH oxidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOX1, NADPH oxidase 1
  • Synonyms
    GP91-2, MOX1, NOH-1, NOH1, NOH-1L
  • Links
    NCBI Gene ID: 27035
    UniProt: Q9Y5S8

  • Chr Location
    Xq22.1; chrX:100843324-100874464 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    102 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for one mutation show abnormal blood vessel morphology and physiology with decreased basal systolic blood pressure. Male hemizygotes for two null mutations exhibit abnormal response to angiotensin II.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    2
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 237038 NCBI Gene Model | MGI Sequence Detail 51286 C57BL/6J ±  kb
    transcript NM_172203 RefSeq | MGI Sequence Detail 2563 Not Specified  
    polypeptide Q8CIZ9 UniProt | EBI | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 218
      Developmental Gene Expression 1
      Gene Ontology 15
      Phenotypes 102
    • Earliest
      J:81679 Banfi B, et al., Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem. 2003 Feb 7;278(6):3510-3
    • Latest
      J:379677 Lee J, et al., NADPH Oxidase Inhibition Promotes Brain Resilience by Attenuating Tauopathy and Neuroinflammation in Alzheimer's Disease. Adv Sci (Weinh). 2025 Nov;12(42):e05495
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory