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Nox1 Gene Detail
Summary
  • Symbol
    Nox1
  • Name
    NADPH oxidase 1
  • Synonyms
    GP91 phox homolog, Nox-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450016
    NCBI Gene: 237038
  • Gene Overview
    MyGene.info: NOX1
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:134086421-134137711 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 55.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    192 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2450016
 protein coding gene ChrX:134086421-134221956 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036061
 protein coding gene ChrX:131235657-131382779 (-)
A/J MGP_AJ_G0036043
 protein coding gene ChrX:130658801-130807731 (-)
AKR/J MGP_AKRJ_G0035962
 protein coding gene ChrX:134831155-135001500 (-)
BALB/cJ MGP_BALBcJ_G0036034
 protein coding gene ChrX:129105402-129244442 (-)
C3H/HeJ MGP_C3HHeJ_G0035738
 protein coding gene ChrX:131312531-131461759 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036556
 protein coding gene ChrX:135098657-135253930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033384
 protein coding gene ChrX:122864052-123000657 (-)
CAST/EiJ MGP_CASTEiJ_G0035025
 protein coding gene ChrX:112192501-112336050 (-)
CBA/J MGP_CBAJ_G0035715
 protein coding gene ChrX:139141596-139302846 (-)
DBA/2J MGP_DBA2J_G0035868
 protein coding gene ChrX:129997272-130134535 (-)
FVB/NJ MGP_FVBNJ_G0035810
 protein coding gene ChrX:129307652-129454827 (-)
LP/J MGP_LPJ_G0035961
 protein coding gene ChrX:132113405-132261929 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035838
 protein coding gene ChrX:146546766-146693587 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036585
 protein coding gene ChrX:130668313-130810266 (-)
PWK/PhJ MGP_PWKPhJ_G0034717
 protein coding gene ChrX:109148804-109287521 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034549
 protein coding gene ChrX:112824676-112970162 (-)
WSB/EiJ MGP_WSBEiJ_G0035162
 protein coding gene ChrX:129048389-129192333 (-)



Homology
more
  • Human Ortholog
    NOX1, NADPH oxidase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NOX1, NADPH oxidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GP91-2, MOX1, NOH1, NOH-1
  • Links
    NCBI Gene ID: 27035
    neXtProt AC: NX_Q9Y5S8
    UniProt: Q9Y5S8

  • Chr Location
    Xq22.1; chrX:100843324-100874345 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 48495
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NOX1
  • Gene Tree
    Nox1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice hemizygous for one mutation show abnormal blood vessel morphology and physiology with decreased basal systolic blood pressure. Male hemizygotes for two null mutations exhibit abnormal response to angiotensin II.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1
  • Tissues
    1
  • cDNA Data
    2
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 237038 NCBI Gene Model | MGI Sequence Detail 51291 C57BL/6J ±  kb
    transcript NM_172203 RefSeq | MGI Sequence Detail 2563 Not Specified  
    polypeptide Q8CIZ9 UniProt | EBI | MGI Sequence Detail 591 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 54
    • Earliest
      J:81679 Banfi B, et al., Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem. 2003 Feb 7;278(6):3510-3
    • Latest
      J:264775 Russo R, et al., Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease. Neurobiol Aging. 2018 Aug;68:123-133
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/15/2019
    MGI 6.13     		The Jackson Laboratory