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Nox1 Gene Detail
Summary
  • Symbol
    Nox1
  • Name
    NADPH oxidase 1
  • Synonyms
    GP91 phox homolog, Nox-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2450016
    NCBI Gene: 237038
  • Gene Overview
    MyGene.info: NOX1
Location & Maps
more
  • Sequence Map
    ChrX:134086421-134221956 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      135536 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 55.69 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NOX1, NADPH oxidase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NOX1, NADPH oxidase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GP91-2, MOX1, NOH1, NOH-1
  • Links
    NCBI Gene ID: 27035
    neXtProt AC: NX_Q9Y5S8

  • Chr Location
    Xq22; chrX:100843324-100874345 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 48495
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: NOX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
Male mice hemizygous for one mutation show abnormal blood vessel morphology and physiology with decreased basal systolic blood pressure. Male hemizygotes for two null mutations exhibit abnormal response to angiotensin II.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019159 VEGA Gene Model | MGI Sequence Detail 135536 C57BL/6J ±  kb
transcript OTTMUST00000045925 VEGA | MGI Sequence Detail 2563 Not Applicable  
polypeptide OTTMUSP00000020697 VEGA | MGI Sequence Detail 563 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    428 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 70
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 42
  • Earliest
    J:81679 Banfi B, et al., Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem. 2003 Feb 7;278(6):3510-3
  • Latest
    J:231185 Hsieh LT, et al., Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1beta synthesis. Matrix Biol. 2016 Jan;49:61-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory