Map3k9 MGI Mouse Gene Detail - MGI:2449952 - mitogen-activated protein kinase kinase kinase 9

Symbol

Map3k9
Name

mitogen-activated protein kinase kinase kinase 9
Synonyms

E130314H24Rik, Mlk1

Feature Type

protein coding gene
IDs

MGI:2449952
NCBI Gene: 338372
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:81767784-81827949 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 37.91 cM
Mapping Data

2 experiments

SNPs within 2kb

1826 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2449952	protein coding gene	Chr12:81761724-81828010 (-)
129S1/SvImJ	ENSMUSG00200049912	protein coding gene	Chr12:73738059-73798227 (-)
A/J	ENSMUSG00195029519	protein coding gene	Chr12:76431741-76491885 (-)
AKR/J	ENSMUSG00220048446	protein coding gene	Chr12:74227118-74287271 (-)
BALB/cJ	ENSMUSG00180017049	protein coding gene	Chr12:75402362-75462531 (-)
C3H/HeJ	ENSMUSG00175035072	protein coding gene	Chr12:78563825-78623963 (-)
C57BL/6NJ	ENSMUSG00215044568	protein coding gene	Chr12:74767851-74828030 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017913	protein coding gene	Chr12:76156378-76229691 (-)
CAST/EiJ	ENSTCUG00005031483	protein coding gene	Chr12:74697614-74758371 (-)
CBA/J	ENSMUSG00210035729	protein coding gene	Chr12:74978038-75038183 (-)
DBA/2J	ENSMUSG00185039364	protein coding gene	Chr12:76838867-76899006 (-)
FVB/NJ	ENSMUSG00205022858	protein coding gene	Chr12:74575897-74636082 (-)
JF1/MsJ	ENSUMUG00000033120	protein coding gene	Chr12:80832598-80893724 (-)
LP/J	ENSMUSG00230042993	protein coding gene	Chr12:83856033-83916205 (-)
NOD/ShiLtJ	ENSMUSG00190043675	protein coding gene	Chr12:74035770-74095948 (-)
NZO/HlLtJ	ENSMUSG00225048750	protein coding gene	Chr12:85911690-85971861 (-)
PWK/PhJ	ENSLUMG00010023637	protein coding gene	Chr12:74829627-74891257 (-)
SPRET/EiJ	ENSMSPG00010016170	protein coding gene	Chr12:76660398-76723617 (-)
WSB/EiJ	ENSIUOG00005039368	protein coding gene	Chr12:74649647-74709817 (-)

Human Ortholog

MAP3K9, mitogen-activated protein kinase kinase kinase 9

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP3K9, mitogen-activated protein kinase kinase kinase 9
Synonyms

MEKK9, MLK1, PRKE1
Links

HGNC:6861

NCBI Gene ID: 4293

UniProt: P80192
Chr Location

14q24.2; chr14:70722526-70809545 (-) GRCh38

MGI Vertebrate Homology

Map3k9 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP3K9
Protein SuperFamily

MAPKKK9_11
Gene Tree

Map3k9

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

2
Genomic Mutations

1 involving Map3k9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter/null allele exhibit normal development, reproduction and lifespan.

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All GO Annotations

17
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

41

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase map3k9

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All Sequences

49
RefSeq

11
UniProt

3
CCDS

CCDS49104.1

Ensembl

ENSMUSG00000042724 (Evidence)
NCBI Gene

338372

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042724	Ensembl Gene Model \| MGI Sequence Detail	60166	C57BL/6J	± kb
transcript	ENSMUST00000222322	Ensembl \| MGI Sequence Detail	3303	Not Applicable
polypeptide	ENSMUSP00000152201	Ensembl \| MGI Sequence Detail	1100	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010141 mitogen-activated protein kinase kinase kinase 9

(term hierarchy)
EC

2.7.11.25
InterPro Domains

IPR016231 Mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4

IPR035779 MLK1-3, SH3 domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR051681 Serine/Threonine Kinases and Pseudokinases

IPR008271 Serine/threonine-protein kinase, active site

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

Q3U1V8 1 site

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All nucleic 41

cDNA 41

Microarray probesets 3

Summaries

All 42

Gene Ontology 8

Phenotypes 9
Earliest

J:70600 Thompson NA, et al., Islet-brain1/JNK-interacting protein-1 is required for early embryogenesis in mice. J Biol Chem. 2001 Jul 27;276(30):27745-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Map3k9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116936	Chr12:81827895-81827950 (-)	26 bp
Tssr116935	Chr12:81827817-81827840 (-)	120 bp
Tssr116934	Chr12:81811901-81811904 (-)	16,046 bp
Tssr3882	Chr12:81811236-81811282 (-)	16,690 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24