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Map3k9 Gene Detail
Summary
  • Symbol
    Map3k9
  • Name
    mitogen-activated protein kinase kinase kinase 9
  • Synonyms
    E130314H24Rik, Mlk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449952
    NCBI Gene: 338372
  • Gene Overview
    MyGene.info: MAP3K9
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:81721010-81781175 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 37.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449952
protein coding gene Chr12:81714950-81781425 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019907
protein coding gene Chr12:82200781-82273280 (-)
A/J MGP_AJ_G0019864
protein coding gene Chr12:79189499-79255779 (-)
AKR/J MGP_AKRJ_G0019840
protein coding gene Chr12:81336377-81403217 (-)
BALB/cJ MGP_BALBcJ_G0019844
protein coding gene Chr12:79421036-79499671 (-)
C3H/HeJ MGP_C3HHeJ_G0019650
protein coding gene Chr12:81803946-81873683 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020296
protein coding gene Chr12:84584520-84659701 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017913
protein coding gene Chr12:76156378-76229691 (-)
CAST/EiJ MGP_CASTEiJ_G0019199
protein coding gene Chr12:76683448-76757491 (-)
CBA/J MGP_CBAJ_G0019621
protein coding gene Chr12:87866764-87942370 (-)
DBA/2J MGP_DBA2J_G0019736
protein coding gene Chr12:78766633-78834357 (-)
FVB/NJ MGP_FVBNJ_G0019722
protein coding gene Chr12:77617949-77685256 (-)
LP/J MGP_LPJ_G0019808
protein coding gene Chr12:82116653-82188111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019761
protein coding gene Chr12:90857176-90927794 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020330
protein coding gene Chr12:80871651-80940023 (-)
PWK/PhJ MGP_PWKPhJ_G0018964
protein coding gene Chr12:73174164-73245661 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018758
protein coding gene Chr12:75377725-75453245 (-)
WSB/EiJ MGP_WSBEiJ_G0019251
protein coding gene Chr12:81520695-81591003 (-)



Homology
more
  • Human Ortholog
    MAP3K9, mitogen-activated protein kinase kinase kinase 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP3K9, mitogen-activated protein kinase kinase kinase 9
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MEKK9, MLK1, PRKE1
  • Links
    NCBI Gene ID: 4293
    neXtProt AC: NX_P80192
    UniProt: P80192

  • Chr Location
    14q24.2; chr14:70722526-70809268 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    4 phenotype references
Mice homozygous for a reporter/null allele exhibit normal development, reproduction and lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042724 Ensembl Gene Model | MGI Sequence Detail 60166 C57BL/6J ±  kb
transcript ENSMUST00000222322 Ensembl | MGI Sequence Detail 3303 Not Applicable  
polypeptide ENSMUSP00000152201 Ensembl | MGI Sequence Detail 1100 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Gene Ontology 7
    Phenotypes 4
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:202816 Wajapeyee N, et al., Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 2013 Oct 15;27(20):2221-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory