Il36g MGI Mouse Gene Detail - MGI:2449929

Symbol

Il36g
Name

interleukin 36G
Synonyms

If36g, Il1f9, IL-36gamma

Feature Type

protein coding gene
IDs

MGI:2449929
NCBI Gene: 215257
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:24076488-24083579 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 16.24 cM
Mapping Data

2 experiments

SNPs within 2kb

205 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2449929	protein coding gene	Chr2:24076488-24083580 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025404	protein coding gene	Chr2:21969667-21978019 (+)
A/J	MGP_AJ_G0025381	protein coding gene	Chr2:21130783-21137495 (+)
AKR/J	MGP_AKRJ_G0025350	protein coding gene	Chr2:21833905-21857087 (+)
BALB/cJ	MGP_BALBcJ_G0025376	protein coding gene	Chr2:21239941-21247612 (+)
C3H/HeJ	MGP_C3HHeJ_G0025137	protein coding gene	Chr2:21791951-21802556 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025821	protein coding gene	Chr2:22664186-22675734 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023232	protein coding gene	Chr2:20082497-20091924 (+)
CAST/EiJ	MGP_CASTEiJ_G0024602	protein coding gene	Chr2:21660130-21668749 (-)
CBA/J	MGP_CBAJ_G0025115	protein coding gene	Chr2:23494538-23502878 (+)
DBA/2J	MGP_DBA2J_G0025249	protein coding gene	Chr2:20996188-21003789 (+)
FVB/NJ	MGP_FVBNJ_G0025211	protein coding gene	Chr2:20727397-20734952 (+)
LP/J	MGP_LPJ_G0025334	protein coding gene	Chr2:21906845-21913657 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025242	protein coding gene	Chr2:23706490-23723935 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025880	protein coding gene	Chr2:21767580-21775535 (+)
PWK/PhJ	MGP_PWKPhJ_G0024349	protein coding gene	Chr2:20781159-20788613 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024149	protein coding gene	Chr2:21892662-21899234 (+)
WSB/EiJ	MGP_WSBEiJ_G0024670	protein coding gene	Chr2:21861547-21869665 (+)

Human Ortholog

IL36G, interleukin 36 gamma

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL36G, interleukin 36 gamma
Synonyms

IL1E, IL-1F9, IL1F9, IL-1H1, IL1H1, IL-1RP2, IL1RP2
Links

HGNC:15741

NCBI Gene ID: 56300

UniProt: Q9NZH8
Chr Location

2q14.1; chr2:112973203-112985658 (+) GRCh38

MGI Vertebrate Homology

Il36g stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IL36G
Gene Tree

Il36g

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Phenotype Summary

23 phenotypes from 1 allele in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

9
Targeted

3
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased susceptibility to HSV-2 infection, influenza A infection, and S. pneumoniae and K. pneumonia infection, and decreased susceptibility to induced colitis, with defects in cytokine levels and macrophage physiology in response to infection.

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All GO Annotations

30
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS50518.1

Ensembl

ENSMUSG00000044103 (Evidence)
NCBI Gene

215257

			Length	Strain/Species	Flank
genomic	215257	NCBI Gene Model \| MGI Sequence Detail	7092	C57BL/6J	± kb
transcript	NM_153511	RefSeq \| MGI Sequence Detail	1647	ZRU/MplStud
polypeptide	Q8R460	UniProt \| EBI \| MGI Sequence Detail	164	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008990 interleukin-1 family member 9

(term hierarchy)
InterPro Domains

IPR008996 Cytokine IL1/FGF

IPR000975 Interleukin-1 family

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All nucleic 8

cDNA 8

Microarray probesets 2

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MGI:6479859, MGI:6487884

Summaries

All 53

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 19
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:340785 Anzaghe M, et al., Interleukin-36gamma is causative for liver damage upon infection with Rift Valley fever virus in type I interferon receptor-deficient mice. Front Immunol. 2023;14:1194733

TSS for Il36g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16555	Chr2:24076325-24076334 (+)	-158 bp
Tssr16556	Chr2:24076405-24076414 (+)	-78 bp
Tssr16557	Chr2:24076447-24076463 (+)	-33 bp
Tssr16558	Chr2:24076465-24076476 (+)	-17 bp
Tssr16559	Chr2:24076481-24076496 (+)	1 bp
Tssr16560	Chr2:24076517-24076524 (+)	33 bp
Tssr16561	Chr2:24076782-24076805 (+)	306 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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