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Egfl7
Gene Detail
Symbol

Name
ID
Egfl7
EGF-like domain 7
MGI:2449923
Synonyms
vascular endothelial-statin, VE-statin, Zneu1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
18.95 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:26580014-26593120 bp, + strand
From VEGA annotation of GRCm38

  13107 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9427  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Egfl7

Human
homologs
Human Homolog EGFL7, EGF-like-domain, multiple 7
NCBI Gene ID 51162
neXtProt AC  NX_Q9UHF1
Human Synonyms  NEU1, VE-STATIN, ZNEU1
Human Chr (Location)  9q34.3; chr9:136658856-136672678 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit some embryonic lethality with absent heartbeat and systemic edema, delayed vasculogenesis, decreased angiogenesis, abnormal adult vasculature, and low-level hypoxia. Mice homozygous for a null allele that does not disrupt Mirn126 expression are normal.
 
Interactions
Egfl7 interacts with 94 markers (Mir22, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process angiogenesis, cell adhesion, ...
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, Notch binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (114)    Tissues (66)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 63
Northern blot 18
RT-PCR 16
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(65) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000011579 (Evidence)
Ensembl Gene ModelENSMUSG00000026921 (Evidence)
Entrez Gene353156 (Evidence)
UniGene268933
DFCITC1695826, TC1651770, TC1592455, TC1579530, TC1588937
DoTSDT.101375387, DT.94311365, DT.492755, DT.492752, DT.101375388, DT.101713411
NIA Mouse Gene IndexU001521
Consensus CDS ProjectCCDS15807.2, CCDS15808.2
International Mouse Knockout Project StatusEgfl7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011579 VEGA Gene Model | MGI Sequence Detail 13107 C57BL/6J ±  kb
transcript OTTMUST00000098440 VEGA | MGI Sequence Detail 892 Not Applicable 
polypeptide OTTMUSP00000055334 VEGA | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(137) RefSeq(26) UniProt(19)
Polymorphisms
SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013111 EGF, extracellular
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR011489 EMI domain
InterPro IPR000742 Epidermal growth factor-like domain
Protein Ontology PR:000006931 epidermal growth factor-like protein 7
References
(Earliest) J:47981 Xiong JW, et al., Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Dev Dyn. 1998 Jun;212(2):181-97
(Latest) J:213414 Bambino K, et al., Epidermal growth factor-like domain 7 is a marker of the endothelial lineage and active angiogenesis. Genesis. 2014 Jul;52(7):657-70
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory