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Egfl7
Gene Detail
Symbol

Name
ID
Egfl7
EGF-like domain 7
MGI:2449923
Synonyms
vascular endothelial-statin, VE-statin, Zneu1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
18.95 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:26580014-26593120 bp, + strand
From VEGA annotation of GRCm38

  13107 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9427  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EGFL7
Gene Tree: Egfl7

Human
homologs
EGFL7, EGF-like-domain, multiple 7
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51162
neXtProt AC: NX_Q9UHF1

Human Synonyms: NEU1, VE-STATIN, ZNEU1

Human Chr (Location): 9q34.3; chr9:136658856-136672678 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit some embryonic lethality with absent heartbeat and systemic edema, delayed vasculogenesis, decreased angiogenesis, abnormal adult vasculature, and low-level hypoxia. Mice homozygous for a null allele that does not disrupt Mirn126 expression are normal.
 
Interactions
Egfl7 interacts with 94 markers (Mir22, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process angiogenesis, cell adhesion, ...
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, Notch binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (114)    Tissues (66)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 63
Northern blot 18
RT-PCR 16
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EGFL7 ; Xenbase egfl7 ; ZFIN egfl7    NEW 
Molecular
reagents
All nucleic(67) cDNA(65) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000011579 (Evidence)
Ensembl Gene Model ENSMUSG00000026921 (Evidence)
Entrez Gene 353156 (Evidence)
UniGene 268933
DFCI TC1588937, TC1695826, TC1579530, TC1651770, TC1592455
DoTS DT.101713411, DT.101375388, DT.101375387, DT.94311365, DT.492755, DT.492752
NIA Mouse Gene Index U001521
Consensus CDS Project CCDS15807.2, CCDS15808.2
International Mouse Phenotyping Consortium Status Egfl7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011579 VEGA Gene Model | MGI Sequence Detail 13107 C57BL/6J ±  kb
transcript OTTMUST00000027055 VEGA | MGI Sequence Detail 1391 Not Applicable 
polypeptide OTTMUSP00000012328 VEGA | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(22) UniProt(10)
Polymorphisms
SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013111 EGF, extracellular
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR011489 EMI domain
InterPro IPR000742 Epidermal growth factor-like domain
Protein Ontology PR:000006931 epidermal growth factor-like protein 7
References
(Earliest) J:47981 Xiong JW, et al., Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Dev Dyn. 1998 Jun;212(2):181-97
(Latest) J:215075 Takeuchi K, et al., EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay. PLoS One. 2014;9(3):e91849
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory