Egfl7 MGI Mouse Gene Detail - MGI:2449923

Symbol

Egfl7
Name

EGF-like domain 7
Synonyms

vascular endothelial-statin, VE-statin, Zneu1

Feature Type

protein coding gene
IDs

MGI:2449923
NCBI Gene: 353156
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:26471095-26482694 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 18.95 cM, cytoband B
Mapping Data

1 experiment

SNPs within 2kb

385 from dbSNP Build 142
Strain Annotations

23

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2449923	protein coding gene	Chr2:26470026-26483132 (+)
129S1/SvImJ	ENSMUSG00200051373	protein coding gene	Chr2:23460660-23461908 (+)
129S1/SvImJ	ENSMUSGG00200054857	protein coding gene	Chr2:23458271-23460165 (+)
A/J	ENSMUSG00195048206	protein coding gene	Chr2:23549818-23551062 (+)
AKR/J	ENSMUSG00220048590	protein coding gene	Chr2:23667604-23668848 (+)
BALB/cJ	ENSMUSGG00180054992	protein coding gene	Chr2:23559761-23561655 (+)
BALB/cJ	ENSMUSG00180053369	protein coding gene	Chr2:23562150-23563398 (+)
C3H/HeJ	ENSMUSG00175053612	protein coding gene	Chr2:23531558-23532806 (+)
C3H/HeJ	ENSMUSGG00175055171	protein coding gene	Chr2:23529169-23531063 (+)
C57BL/6NJ	ENSMUSG00215044011	protein coding gene	Chr2:23590276-23591524 (+)
C57BL/6NJ	ENSMUSGG00215055210	protein coding gene	Chr2:23587887-23589781 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023319	protein coding gene	Chr2:22477687-22490825 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210017392	protein coding gene	Chr2:23565218-23566466 (+)
CBA/J	ENSMUSGG00210055117	protein coding gene	Chr2:23562829-23564723 (+)
DBA/2J	ENSMUSG00185050550	protein coding gene	Chr2:23463940-23465184 (+)
FVB/NJ	ENSMUSG00205049973	protein coding gene	Chr2:23319064-23320312 (+)
FVB/NJ	ENSMUSGG00205054640	protein coding gene	Chr2:23316675-23318569 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSGG00230055300	protein coding gene	Chr2:25394230-25396124 (+)
LP/J	ENSMUSG00230039047	protein coding gene	Chr2:25396619-25397867 (+)
NOD/ShiLtJ	ENSMUSG00190046969	protein coding gene	Chr2:23555583-23556831 (+)
NOD/ShiLtJ	ENSMUSGG00190055099	protein coding gene	Chr2:23553194-23555088 (+)
NZO/HlLtJ	ENSMUSG00225007472	protein coding gene	Chr2:33134247-33135495 (+)
NZO/HlLtJ	ENSMUSGG00225055721	protein coding gene	Chr2:33131858-33133752 (+)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

EGFL7, EGF like domain multiple 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EGFL7, EGF like domain multiple 7
Synonyms

NEU1, VE-STATIN, ZNEU1
Links

HGNC:20594

NCBI Gene ID: 51162

UniProt: Q9UHF1
Chr Location

9q34.3; chr9:136658284-136672679 (+) GRCh38

MGI Vertebrate Homology

Egfl7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EGFL7
Gene Tree

Egfl7

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Phenotype Summary

9 phenotypes from 4 alleles in 4 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

6
Gene trapped

2
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit some embryonic lethality with absent heartbeat and systemic edema, delayed vasculogenesis, decreased angiogenesis, abnormal adult vasculature, and low-level hypoxia. Mice homozygous for a null allele that does not disrupt Mirn126 expression are normal.

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All GO Annotations

16
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

891
Tissues

144
cDNA Data

68
Literature Summary

24

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EGFL7

Xenbase egfl7

ZFIN egfl7

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All Sequences

95
RefSeq

8
UniProt

11
CCDS

CCDS15807.3, CCDS15808.3

Ensembl

ENSMUSG00000026921 (Evidence)
NCBI Gene

353156

			Length	Strain/Species	Flank
genomic	353156	NCBI Gene Model \| MGI Sequence Detail	11600	C57BL/6J	± kb
transcript	NM_198724	RefSeq \| MGI Sequence Detail	1387	C57BL/6
polypeptide	Q9QXT5	UniProt \| EBI \| MGI Sequence Detail	275	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000006931 epidermal growth factor-like protein 7

(term hierarchy)
InterPro Domains

IPR050969 Developmental Signaling Modulators

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR011489 EMI domain

IPR013111 Epidermal growth factor-like domain, extracellular

IPR049883 NOTCH1, EGF-like calcium-binding domain
GlyGen

Q9QXT5 2 sites

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All nucleic 81

cDNA 71

Primer pair 10

Antibodies 4

Microarray probesets 4

Summaries

All 66

Developmental Gene Expression 24

Gene Ontology 10

Phenotypes 15
Earliest

J:47981 Xiong JW, et al., Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Dev Dyn. 1998 Jun;212(2):181-97
Latest

J:383477 Kim M, et al., Egfl7 regulates embryonic angiogenesis and placental vascular function in mice. Biochem Biophys Res Commun. 2026 Apr 14;819:153770

TSS for Egfl7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16802	Chr2:26471023-26471035 (+)	-66 bp
Tssr16803	Chr2:26471036-26471051 (+)	-51 bp
Tssr16804	Chr2:26471062-26471073 (+)	-27 bp
Tssr16805	Chr2:26471078-26471081 (+)	-15 bp
Tssr16806	Chr2:26471089-26471105 (+)	2 bp
Tssr16807	Chr2:26471134-26471147 (+)	46 bp
Tssr16808	Chr2:26473870-26473886 (+)	2,783 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29