Alpk2 MGI Mouse Gene Detail - MGI:2449492

Symbol

Alpk2
Name

alpha-kinase 2
Synonyms

Hak

Feature Type

protein coding gene
IDs

MGI:2449492
NCBI Gene: 225638
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr18:65398600-65526959 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 38.41 cM
Mapping Data

1 experiment

SNPs within 2kb

7745 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2449492	protein coding gene	Chr18:65398600-65527137 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024507	protein coding gene	Chr18:65386579-65531568 (-)
A/J	MGP_AJ_G0024474	protein coding gene	Chr18:62561051-62689136 (-)
AKR/J	MGP_AKRJ_G0024444	protein coding gene	Chr18:64318832-64459593 (-)
BALB/cJ	MGP_BALBcJ_G0024473	protein coding gene	Chr18:62698491-62828301 (-)
C3H/HeJ	MGP_C3HHeJ_G0024241	protein coding gene	Chr18:64523088-64653706 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024920	protein coding gene	Chr18:67149033-67283049 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022351	protein coding gene	Chr18:62003132-62126695 (-)
CAST/EiJ	MGP_CASTEiJ_G0023714	protein coding gene	Chr18:64482416-64629623 (-)
CBA/J	MGP_CBAJ_G0024211	protein coding gene	Chr18:69320617-69476935 (-)
DBA/2J	MGP_DBA2J_G0024341	protein coding gene	Chr18:62213932-62342255 (-)
FVB/NJ	MGP_FVBNJ_G0024307	protein coding gene	Chr18:61605047-61738282 (-)
LP/J	MGP_LPJ_G0024425	protein coding gene	Chr18:65249150-65386780 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024336	protein coding gene	Chr18:70776402-70910386 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024967	protein coding gene	Chr18:64542063-64667885 (-)
PWK/PhJ	MGP_PWKPhJ_G0023457	protein coding gene	Chr18:62469815-62597993 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023262	protein coding gene	Chr18:64682285-64820073 (-)
WSB/EiJ	MGP_WSBEiJ_G0023778	protein coding gene	Chr18:64392852-64521336 (-)

Human Ortholog

ALPK2, alpha kinase 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALPK2, alpha kinase 2
Synonyms

HAK
Links

HGNC:20565

NCBI Gene ID: 115701

UniProt: Q86TB3
Chr Location

18q21.31-q21.32; chr18:58481247-58629091 (-) GRCh38

MGI Vertebrate Homology

Alpk2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: ALPK2
Gene Tree

Alpk2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

3
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

95 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

3
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase alpk2

ZFIN alpk2

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS50310.1

Ensembl

ENSMUSG00000032845 (Evidence)
NCBI Gene

225638

			Length	Strain/Species	Flank
genomic	225638	NCBI Gene Model \| MGI Sequence Detail	128360	C57BL/6J	± kb
transcript	NM_001037294	RefSeq \| MGI Sequence Detail	7250	C57BL/6
polypeptide	Q91ZB0	UniProt \| EBI \| MGI Sequence Detail	2144	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003966 alpha-protein kinase 2

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR004166 Alpha-type protein kinase, alpha-kinase domain

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR011009 Protein kinase-like domain superfamily

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All nucleic 3

cDNA 3

Microarray probesets 2

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 5
Earliest

J:78800 Ryazanov AG, et al., Alpha-kinases: a new class of protein kinases with a novel catalytic domain. Curr Biol. 1999 Jan 28;9(2):R43-5
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Alpk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153703	Chr18:65527079-65527092 (-)	-127 bp
Tssr153702	Chr18:65527051-65527062 (-)	-98 bp
Tssr153701	Chr18:65527025-65527034 (-)	-71 bp
Tssr153700	Chr18:65526915-65526993 (-)	5 bp
Tssr153699	Chr18:65526769-65526780 (-)	184 bp
Tssr153698	Chr18:65515591-65515602 (-)	11,362 bp
Tssr153697	Chr18:65514967-65514990 (-)	11,980 bp
Tssr153696	Chr18:65514728-65514751 (-)	12,219 bp
Tssr153695	Chr18:65508472-65508487 (-)	18,479 bp
Tssr153694	Chr18:65482827-65482849 (-)	44,121 bp
Tssr153693	Chr18:65461753-65461767 (-)	65,199 bp
Tssr153692	Chr18:65461699-65461715 (-)	65,252 bp
Tssr153691	Chr18:65455210-65455223 (-)	71,742 bp
Tssr153690	Chr18:65440810-65440841 (-)	86,133 bp
Tssr153689	Chr18:65439121-65439136 (-)	87,830 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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