Dmrt3 MGI Mouse Gene Detail - MGI:2449470 - doublesex and mab-3 related transcription factor 3

Symbol

Dmrt3
Name

doublesex and mab-3 related transcription factor 3

Feature Type

protein coding gene
IDs

MGI:2449470
NCBI Gene: 240590
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:25610301-25623921 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 20.50 cM
Mapping Data

1 experiment

SNPs within 2kb

17 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2449470	protein coding gene	Chr19:25610246-25623921 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025003	protein coding gene	Chr19:23921417-23934660 (+)
A/J	MGP_AJ_G0024980	protein coding gene	Chr19:22619942-22633309 (+)
AKR/J	MGP_AKRJ_G0024948	protein coding gene	Chr19:23480093-23493421 (+)
BALB/cJ	MGP_BALBcJ_G0024979	protein coding gene	Chr19:22665996-22679690 (+)
C3H/HeJ	MGP_C3HHeJ_G0024735	protein coding gene	Chr19:23467493-23480853 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025420	protein coding gene	Chr19:24652798-24667619 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022839	protein coding gene	Chr19:22741352-22754667 (+)
CAST/EiJ	MGP_CASTEiJ_G0024205	protein coding gene	Chr19:23211898-23225355 (+)
CBA/J	MGP_CBAJ_G0024713	protein coding gene	Chr19:25724348-25737707 (+)
DBA/2J	MGP_DBA2J_G0024845	protein coding gene	Chr19:22613581-22626939 (+)
FVB/NJ	MGP_FVBNJ_G0024807	protein coding gene	Chr19:22515069-22528965 (+)
LP/J	MGP_LPJ_G0024930	protein coding gene	Chr19:23871870-23885170 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024834	protein coding gene	Chr19:25703914-25717302 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025475	protein coding gene	Chr19:23500646-23515121 (+)
PWK/PhJ	MGP_PWKPhJ_G0023953	protein coding gene	Chr19:22254176-22268108 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023757	protein coding gene	Chr19:22766258-22779709 (+)
WSB/EiJ	MGP_WSBEiJ_G0024272	protein coding gene	Chr19:23523860-23538273 (+)

Human Ortholog

DMRT3, doublesex and mab-3 related transcription factor 3

Vertebrate Orthologs

10

Human Ortholog

DMRT3, doublesex and mab-3 related transcription factor 3
Orthology source: HomoloGene, HGNC
Synonyms

DMRTA3
Links

HGNC:13909

NCBI Gene ID: 58524

neXtProt AC: NX_Q9NQL9

UniProt: Q9NQL9
Chr Location

9p24.3; chr9:976968-991732 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 10935
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DMRT3
Gene Tree

Dmrt3

less

Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele die from starvation at 2 months of age due to dental malocclusions; some males exhibit defects in sexual development. Mutant mice also exhibit locomotor abnormalities. Mice homozygous for a different knock-out allele exhibit decreased neocortex area.

less

All GO Annotations

21
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

883
Tissues

168
cDNA Data

7
Literature Summary

26

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DMRT3

ZFIN dmrt3a

less

Dmrt3 interacts with 144 markers (Mir16-1, Mir19a, Mir26a-1, ...) View All

less

All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS29718.1
UniGene

62785

Ensembl

ENSMUSG00000042372 (Evidence)
NCBI Gene

240590

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042372	Ensembl Gene Model \| MGI Sequence Detail	13621	C57BL/6J	± kb
transcript	ENSMUST00000048935	Ensembl \| MGI Sequence Detail	2391	Not Applicable
polypeptide	ENSMUSP00000046812	Ensembl \| MGI Sequence Detail	476	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000006544 doublesex- and mab-3-related transcription factor 3

(term hierarchy)
InterPro Domains

IPR001275 DM DNA-binding domain

IPR036407 DM DNA-binding domain superfamily

IPR005173 DMRTA motif

IPR026607 DMRT/protein doublesex/protein male abnormal 3

IPR009060 UBA-like superfamily

less

All nucleic 11

Genomic 1

cDNA 7

Primer pair 3

Microarray probesets 2

Summaries

All 48

Developmental Gene Expression 26

Gene Ontology 8

Phenotypes 7
Earliest

J:68323 Carninci P, et al., Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Genome Res. 2000 Oct;10(10):1617-30
Latest

J:284155 Konno D, et al., Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes. Development. 2019 Aug 13;146(15)

TSS for Dmrt3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155699	Chr19:25610256-25610261 (+)	-42 bp
Tssr155700	Chr19:25610533-25610553 (+)	242 bp
Tssr155701	Chr19:25610564-25610576 (+)	269 bp
Tssr155702	Chr19:25610923-25610947 (+)	634 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/16/2021 MGI 6.16