About   Help   FAQ
Scarf1 Gene Detail
Summary
  • Symbol
    Scarf1
  • Name
    scavenger receptor class F, member 1
  • Synonyms
    SREC, SREC-I
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449455
    NCBI Gene: 380713
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75513540-75526582 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449455
protein coding gene Chr11:75513489-75526582 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018716
protein coding gene Chr11:76266751-76282537 (+)
A/J MGP_AJ_G0018682
protein coding gene Chr11:73430072-73445579 (+)
AKR/J MGP_AKRJ_G0018652
protein coding gene Chr11:75655393-75670170 (+)
BALB/cJ MGP_BALBcJ_G0018656
protein coding gene Chr11:73802906-73815787 (+)
C3H/HeJ MGP_C3HHeJ_G0018469
protein coding gene Chr11:75669789-75682430 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019107
protein coding gene Chr11:78678839-78691954 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016742
protein coding gene Chr11:70443386-70456235 (+)
CAST/EiJ MGP_CASTEiJ_G0018023
protein coding gene Chr11:76064383-76079471 (+)
CBA/J MGP_CBAJ_G0018439
protein coding gene Chr11:82114138-82134748 (+)
DBA/2J MGP_DBA2J_G0018548
protein coding gene Chr11:73034362-73050143 (+)
FVB/NJ MGP_FVBNJ_G0018538
protein coding gene Chr11:72594913-72608693 (+)
LP/J MGP_LPJ_G0018619
protein coding gene Chr11:76853452-76868006 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018564
protein coding gene Chr11:82672015-82685523 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019147
protein coding gene Chr11:75862872-75877015 (+)
PWK/PhJ MGP_PWKPhJ_G0017794
protein coding gene Chr11:73732231-73746082 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017585
protein coding gene Chr11:75411921-75428957 (+)
WSB/EiJ MGP_WSBEiJ_G0018076
protein coding gene Chr11:75669559-75684296 (+)



Homology
more
  • Human Ortholog
    SCARF1, scavenger receptor class F member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SCARF1, scavenger receptor class F member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SREC, SREC1, SREC-I
  • Links
    NCBI Gene ID: 8578
    neXtProt AC: NX_Q14162
    UniProt: Q14162

  • Chr Location
    17p13.3; chr17:1633858-1645789 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2741
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SCARF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile with no abnormalities detected in plasma glucose, cholesterol, or triglycerides, or in the brain, lung, heart, kidney, liver, or testes. Mice homozygous for a targeted allele exhibit impaired clearance of apoptotic cells and autoimmune disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038188 Ensembl Gene Model | MGI Sequence Detail 13043 C57BL/6J ±  kb
    transcript ENSMUST00000042808 Ensembl | MGI Sequence Detail 2887 Not Applicable  
    polypeptide ENSMUSP00000044248 Ensembl | MGI Sequence Detail 820 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144059
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:208237 Ramirez-Ortiz ZG, et al., The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity. Nat Immunol. 2013 Sep;14(9):917-26

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    02/11/2020
    MGI 6.14
    The Jackson Laboratory