Syne2
Gene Detail

Symbol Name ID

Syne2 spectrin repeat containing, nuclear envelope 2 MGI:2449316

Synonyms

6820443O06Rik, D12Ertd777e, mKIAA1011, Nesp2g, nesprin-2, syne-2

Feature Type

protein coding gene

Genetic Map

Chromosome 12

33.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:75818134-76110926 bp, + strand From VEGA annotation of GRCm38   292793 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56700  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Syne2

Human homologs

Human Homolog		SYNE2, spectrin repeat containing, nuclear envelope 2
NCBI Gene ID		23224
neXtProt AC		NX_Q8WXH0
Human Synonyms		EDMD5, Nesp2, Nesprin-2, NUA, NUANCE, SYNE-2, TROPH
Human Chr (Location)		14q23.2; chr14:64319683-64693167 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SYNE2

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(4)
 

Homozygotes for one knock-out allele show normal myonuclear positioning of both synaptic and non-synaptic nuclei in skeletal muscle cells. Homozygotes for another knock-out allele exhibit a thickened epidermis and altered nuclear envelope architecture in primary dermal fibroblasts and keratinocytes.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	centrosome localization, cytoskeletal anchoring at nuclear membrane, ...
Component	cytoplasm, cytoskeleton, ...
Function	actin binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (167)    Tissues (102)    Images (39)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	167

cDNA source data(154)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(156) cDNA(154) Primer pair(2)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000033019 (Evidence)
Ensembl Gene Model	ENSMUSG00000063450 (Evidence)
Entrez Gene	319565 (Evidence)
UniGene	26652
DFCI	TC1576506, TC1587182, TC1597023, TC1609243, TC1615196, TC1616175, TC1631696, TC1672737
DoTS	DT.101274258, DT.101360236, DT.110952803, DT.55155214, DT.87039274, DT.91411373, DT.94242967, DT.94369911, DT.97342529, DT.99852103
NIA Mouse Gene Index	U151312
Consensus CDS Project	CCDS49091.1
International Mouse Knockout Project Status	Syne2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033019	VEGA Gene Model | MGI Sequence Detail	292793	C57BL/6J
transcript	OTTMUST00000082377	VEGA | MGI Sequence Detail	21704	Not Applicable
polypeptide	OTTMUSP00000044144	VEGA | MGI Sequence Detail	6870	Not Applicable

All sequences(123) RefSeq(2) UniProt(18)

Polymorphisms

SNPs(2397 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001589	Actinin-type, actin-binding, conserved site
InterPro	IPR001715	Calponin homology domain
InterPro	IPR012315	Klarsicht/ANC-1/syne-1 homology
InterPro	IPR018159	Spectrin/alpha-actinin
InterPro	IPR002017	Spectrin repeat
Protein Ontology	PR:000015876	nesprin-2

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:192230 Razafsky D, et al., LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina. PLoS One. 2012;7(10):e47180
All references(50)

Other accession IDs

MGI:1289287, MGI:2145039, MGI:2442286