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Gemin4 Gene Detail
Summary
  • Symbol
    Gemin4
  • Name
    gem nuclear organelle associated protein 4
  • Synonyms
    MGC:28146
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449313
    NCBI Gene: 276919
  • Gene Overview
    MyGene.info: GEMIN4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:76210571-76217572 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449313
protein coding gene Chr11:76210571-76217664 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018730
protein coding gene Chr11:77030377-77039879 (-)
A/J MGP_AJ_G0018696
protein coding gene Chr11:74153955-74161474 (-)
AKR/J MGP_AKRJ_G0018666
protein coding gene Chr11:76396380-76408731 (-)
BALB/cJ MGP_BALBcJ_G0018670
protein coding gene Chr11:74543871-74544309 (-)
C3H/HeJ MGP_C3HHeJ_G0018483
protein coding gene Chr11:76416704-76423787 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019121
protein coding gene Chr11:79438076-79445163 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016756
protein coding gene Chr11:71151921-71158951 (-)
CAST/EiJ MGP_CASTEiJ_G0018037
protein coding gene Chr11:76812676-76819972 (-)
CBA/J MGP_CBAJ_G0018453
protein coding gene Chr11:82932346-82942083 (-)
DBA/2J MGP_DBA2J_G0018562
protein coding gene Chr11:73750723-73758289 (-)
FVB/NJ MGP_FVBNJ_G0018552
protein coding gene Chr11:73303015-73310791 (-)
LP/J MGP_LPJ_G0018633
protein coding gene Chr11:77607089-77615193 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018578
protein coding gene Chr11:83429039-83436128 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019161
protein coding gene Chr11:76597697-76604417 (-)
PWK/PhJ MGP_PWKPhJ_G0017808
protein coding gene Chr11:74469230-74477708 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017599
protein coding gene Chr11:76167523-76167975 (-)
WSB/EiJ MGP_WSBEiJ_G0018090
protein coding gene Chr11:76418547-76425300 (-)



Homology
more
  • Human Ortholog
    GEMIN4, gem nuclear organelle associated protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GEMIN4, gem nuclear organelle associated protein 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HC56, HCAP1, HHRF-1, NEDMCR, p97
  • Links
    NCBI Gene ID: 50628
    neXtProt AC: NX_P57678
    UniProt: P57678

  • Chr Location
    17p13.3; chr17:744421-752868 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 69193
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GEMIN4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele die before E5.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 276919 NCBI Gene Model | MGI Sequence Detail 7002 C57BL/6J ±  kb
transcript NM_177367 RefSeq | MGI Sequence Detail 3448 C57BL/6  
polypeptide NP_796341 RefSeq | MGI Sequence Detail 1058 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR033265 Gem-associated protein 4
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144371
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:256720 Meier ID, et al., Gemin4 is an essential gene in mice, and its overexpression in human cells causes relocalization of the SMN complex to the nucleoplasm. Biol Open. 2018 Feb 1;7(2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory