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Nr1d2
Gene Detail
Symbol

Name
ID
Nr1d2
nuclear receptor subfamily 1, group D, member 2
MGI:2449205
Synonyms
Rev-erb beta, RVR
Feature Type
protein coding gene
Genetic Map
Chromosome 14
7.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:18204054-18239127 bp, - strand
From VEGA annotation of GRCm38

  35074 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3763  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: NR1D2
Gene Tree: Nr1d2

Human
homologs
NR1D2, nuclear receptor subfamily 1, group D, member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9975
neXtProt AC: NX_Q14995

Human Synonyms: BD73, EAR-1R, RVR

Human Chr (Location): 3p24.2; chr3:23945260-23980618 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit no gross abnormalities.
 
Interactions
Nr1d2 interacts with 413 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process lipid homeostasis, negative regulation of transcription, DNA-templated, ...
Component nucleus
Function core promoter sequence-specific DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (168)    Tissues (165)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 147
Northern blot 13
RT-PCR 8
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nr1d2 ; ZFIN nr1d2a, nr1d2b    NEW 
Molecular
reagents
All nucleic(16) cDNA(14) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000033210 (Evidence)
Ensembl Gene Model ENSMUSG00000021775 (Evidence)
Entrez Gene 353187 (Evidence)
DFCI TC1598114, TC1592641, TC1582630, TC1602755
DoTS DT.99845394, DT.531489, DT.97414252
NIA Mouse Gene Index U019436, U035262
PDB 1EFJ
Consensus CDS Project CCDS36811.1
International Mouse Phenotyping Consortium Status Nr1d2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033210 VEGA Gene Model | MGI Sequence Detail 35074 C57BL/6J ±  kb
transcript OTTMUST00000083162 VEGA | MGI Sequence Detail 4663 Not Applicable 
polypeptide OTTMUSP00000044638 VEGA | MGI Sequence Detail 576 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(229 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023257 Liver X receptor
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR001728 Thyroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011393 nuclear receptor subfamily 1 group D member 2
References
(Earliest) J:20436 Retnakaran R, et al., Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator. Mol Endocrinol. 1994 Sep;8(9):1234-44
(Latest) J:203378 Yang F, et al., Real-time analysis of the circadian oscillation of the Rev-Erb beta promoter. J Atheroscler Thromb. 2013;20(3):267-76
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory