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Nr1d2 Gene Detail
Summary
  • Symbol
    Nr1d2
  • Name
    nuclear receptor subfamily 1, group D, member 2
  • Synonyms
    Rev-erb beta, RVR
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449205
    NCBI Gene: 353187
  • Gene Overview
    MyGene.info: NR1D2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:18204054-18239127 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35074 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 7.08 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NR1D2, nuclear receptor subfamily 1 group D member 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NR1D2, nuclear receptor subfamily 1 group D member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BD73, EAR-1R, REVERBB, REVERBbeta, RVR
  • Links
    NCBI Gene ID: 9975
    neXtProt AC: NX_Q14995
    UniProt: Q14995

  • Chr Location
    3p24.2; chr3:23945260-23980618 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Nr1d2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit no gross abnormalities. Mice homozygous for a different knock-out allele display an increased anxiety-related response. A subset of mice homozygous for a third knock-out allele show neonatal lethality, atrioventricular septal defects (AVSDs) and related cardiovascular malformations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033210 VEGA Gene Model | MGI Sequence Detail 35074 C57BL/6J ±  kb
    transcript OTTMUST00000083162 VEGA | MGI Sequence Detail 4663 Not Applicable  
    polypeptide OTTMUSP00000044638 VEGA | MGI Sequence Detail 576 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      221 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 2
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:20436 Retnakaran R, et al., Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator. Mol Endocrinol. 1994 Sep;8(9):1234-44
    • Latest
      J:265505 Amador A, et al., Distinct roles for REV-ERBalpha and REV-ERBbeta in oxidative capacity and mitochondrial biogenesis in skeletal muscle. PLoS One. 2018;13(5):e0196787

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory