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Nr1d2 Gene Detail
Summary
  • Symbol
    Nr1d2
  • Name
    nuclear receptor subfamily 1, group D, member 2
  • Synonyms
    Rev-erb beta, RVR
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449205
    NCBI Gene: 353187
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:4230569-4265642 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 7.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    221 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449205
 protein coding gene Chr14:4230549-4265642 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0020967
 protein coding gene Chr14:10492451-10538361 (-)
AKR/J MGP_AKRJ_G0020944
 protein coding gene Chr14:10819803-10846186 (-)
BALB/cJ MGP_BALBcJ_G0020970
 protein coding gene Chr14:10557350-10601269 (-)
C3H/HeJ MGP_C3HHeJ_G0020754
 protein coding gene Chr14:10904186-10935831 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021403
 protein coding gene Chr14:11201479-11230480 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018972
 protein coding gene Chr14:11014427-11042897 (-)
CAST/EiJ MGP_CASTEiJ_G0020277
 protein coding gene Chr14:10768007-10796663 (-)
CBA/J MGP_CBAJ_G0020720
 protein coding gene Chr14:11684842-11715568 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0020826
 protein coding gene Chr14:10271644-10307476 (-)
LP/J MGP_LPJ_G0020919
 protein coding gene Chr14:10865546-10904406 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020852
 protein coding gene Chr14:11548401-11591495 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021436
 protein coding gene Chr14:10680343-10728947 (-)
PWK/PhJ MGP_PWKPhJ_G0020028
 protein coding gene Chr14:10466971-10496258 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019849
 protein coding gene Chr14:10836228-10870871 (-)
WSB/EiJ MGP_WSBEiJ_G0020334
 protein coding gene Chr14:10761052-10782449 (-)



Homology
more
  • Human Ortholog
    NR1D2, nuclear receptor subfamily 1 group D member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR1D2, nuclear receptor subfamily 1 group D member 2
  • Synonyms
    BD73, EAR-1R, REVERBB, REVERBbeta, RVR
  • Links
    NCBI Gene ID: 9975
    neXtProt AC: NX_Q14995
    UniProt: Q14995

  • Chr Location
    3p24.2; chr3:23945286-23980617 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nr1d2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit no gross abnormalities. Mice homozygous for a different knock-out allele display an increased anxiety-related response. A subset of mice homozygous for a third knock-out allele show neonatal lethality, atrioventricular septal defects (AVSDs) and related cardiovascular malformations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    174
  • cDNA Data
    14
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021775 Ensembl Gene Model | MGI Sequence Detail 35074 C57BL/6J ±  kb
    transcript ENSMUST00000090543 Ensembl | MGI Sequence Detail 4663 Not Applicable  
    polypeptide ENSMUSP00000088031 Ensembl | MGI Sequence Detail 576 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 15
      Primer pair 3
      Other 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 17
      Phenotypes 30
    • Earliest
      J:20436 Retnakaran R, et al., Identification of RVR, a novel orphan nuclear receptor that acts as a negative transcriptional regulator. Mol Endocrinol. 1994 Sep;8(9):1234-44
    • Latest
      J:344325 Woodie LN, et al., Hindbrain REV-ERB nuclear receptors regulate sensitivity to diet-induced obesity and brown adipose tissue pathophysiology. Mol Metab. 2023 Dec 23;79:101861
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory