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Cadm4 Gene Detail
Summary
  • Symbol
    Cadm4
  • Name
    cell adhesion molecule 4
  • Synonyms
    Igsf4c, Necl-4, SynCAM 4, Tsll2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449088
    NCBI Gene: 260299
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24482023-24504533 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 11.03 cM, cytoband A3-B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449088
protein coding gene Chr7:24482023-24504539 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031830
protein coding gene Chr7:22805951-22831574 (+)
A/J MGP_AJ_G0031809
protein coding gene Chr7:22284089-22307803 (+)
AKR/J MGP_AKRJ_G0031738
protein coding gene Chr7:22784651-22807198 (+)
BALB/cJ MGP_BALBcJ_G0031815
protein coding gene Chr7:22498513-22522583 (+)
C3H/HeJ MGP_C3HHeJ_G0031535
protein coding gene Chr7:23199685-23227322 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032278
protein coding gene Chr7:23557641-23581488 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029336
protein coding gene Chr7:23756036-23778148 (+)
CAST/EiJ MGP_CASTEiJ_G0030876
protein coding gene Chr7:16671881-16701890 (+)
CBA/J MGP_CBAJ_G0031500
protein coding gene Chr7:24442762-24474125 (+)
DBA/2J MGP_DBA2J_G0031654
protein coding gene Chr7:22198031-22220444 (+)
FVB/NJ MGP_FVBNJ_G0031607
protein coding gene Chr7:22162514-22190119 (+)
LP/J MGP_LPJ_G0031733
protein coding gene Chr7:23164363-23189158 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031644
protein coding gene Chr7:24212893-24237831 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032310
protein coding gene Chr7:22503424-22526906 (+)
PWK/PhJ MGP_PWKPhJ_G0030600
protein coding gene Chr7:17089350-17112836 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030430
protein coding gene Chr7:13832114-13858471 (+)
WSB/EiJ MGP_WSBEiJ_G0030979
protein coding gene Chr7:22627586-22652453 (+)



Homology
more
  • Human Ortholog
    CADM4, cell adhesion molecule 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CADM4, cell adhesion molecule 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IGSF4C, Necl-4, NECL4, synCAM4, TSLL2
  • Links
    NCBI Gene ID: 199731
    neXtProt AC: NX_Q8NFZ8
    UniProt: Q8NFZ8

  • Chr Location
    19q13.31; chr19:43622368-43641984 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele do not display myelination abnormalities. Mice with ubiquitous conditional deletion of the gene show myelination abnormalities, decreased nerve conduction velocity, hindlimb rigidity, limb grasping, and impaired coordination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 260299 NCBI Gene Model | MGI Sequence Detail 22511 C57BL/6J ±  kb
transcript NM_153112 RefSeq | MGI Sequence Detail 2155 C57BL/6  
polypeptide Q8R464 UniProt | EBI | MGI Sequence Detail 388 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 25
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:86990 Fukami T, et al., Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2). Gene. 2003 Dec 24;323:11-8
  • Latest
    J:269651 Elazar N, et al., Axoglial Adhesion by Cadm4 Regulates CNS Myelination. Neuron. 2018 Dec 5;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory