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Cxcr1 Gene Detail
Summary
  • Symbol
    Cxcr1
  • Name
    chemokine (C-X-C motif) receptor 1
  • Synonyms
    Il8ra
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448715
    NCBI Gene: 227288
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:74191785-74194631 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448715
protein coding gene Chr1:74191785-74195436 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016142
protein coding gene Chr1:74775043-74777887 (-)
A/J MGP_AJ_G0016125
protein coding gene Chr1:72157942-72160784 (-)
AKR/J MGP_AKRJ_G0016082
protein coding gene Chr1:74169248-74172094 (-)
BALB/cJ MGP_BALBcJ_G0016080
protein coding gene Chr1:72230399-72233245 (-)
C3H/HeJ MGP_C3HHeJ_G0015911
protein coding gene Chr1:74491674-74494516 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016533
protein coding gene Chr1:77683995-77686841 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014254
protein coding gene Chr1:67737898-67740725 (-)
CAST/EiJ MGP_CASTEiJ_G0015495
protein coding gene Chr1:73803231-73806087 (-)
CBA/J MGP_CBAJ_G0015884
protein coding gene Chr1:80197402-80200244 (-)
DBA/2J MGP_DBA2J_G0015985
protein coding gene Chr1:71492237-71495083 (-)
FVB/NJ MGP_FVBNJ_G0015988
protein coding gene Chr1:70667607-70670453 (-)
LP/J MGP_LPJ_G0016057
protein coding gene Chr1:75873097-75875941 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016008
protein coding gene Chr1:83627818-83630646 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016580
protein coding gene Chr1:74223220-74226064 (-)
PWK/PhJ MGP_PWKPhJ_G0015282
protein coding gene Chr1:70934267-70937119 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015060
protein coding gene Chr1:73586068-73588899 (-)
WSB/EiJ MGP_WSBEiJ_G0015557
protein coding gene Chr1:74026502-74029346 (-)



Homology
more
  • Human Ortholog
    CXCR1, C-X-C motif chemokine receptor 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CXCR1, C-X-C motif chemokine receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
  • Links
    NCBI Gene ID: 3577
    neXtProt AC: NX_P25024
    UniProt: P25024

  • Chr Location
    2q35; chr2:218162845-218166993 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CXCR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene disruption display normal morphology, clinical chemistry, hematology, and behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048480 Ensembl Gene Model | MGI Sequence Detail 2847 C57BL/6J ±  kb
transcript ENSMUST00000190313 Ensembl | MGI Sequence Detail 1451 Not Applicable  
polypeptide ENSMUSP00000139555 Ensembl | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR000174 CXC chemokine receptor 1/2
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 3
    cDNA 2
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 18
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:257943 Marazioti A, et al., Myeloid-derived interleukin-1beta drives oncogenic KRAS-NF-kappaBeta addiction in malignant pleural effusion. Nat Commun. 2018 Feb 14;9(1):672

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory