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Cxcr1
Gene Detail
 Symbol
Name
ID
Cxcr1
chemokine (C-X-C motif) receptor 1
MGI:2448715
Synonyms Il8ra
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:74191785-74194631 bp, - strand
From VEGA annotation of GRCm38

  2847 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68074  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr1

Human
homologs
Human Homolog CXCR1, chemokine (C-X-C motif) receptor 1
NCBI Gene ID 3577
neXtProt AC  NX_P25024
Human Synonyms  C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
Human Chr (Location)  2q35; chr2:218162845-218166993 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CXCR1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene disruption display normal morphology, clinical chemistry, hematology, and behavior.
 
Interactions
Cxcr1 interacts with 9 markers (Mir148b, Mir152, Mir299b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell surface receptor signaling pathway, chemokine-mediated signaling pathway, ...
Component integral component of membrane, membrane, ...
Function chemokine receptor activity, C-X-C chemokine receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (35)    Tissues (35)    Images (1)
Theiler Stages: 28
Assay TypeResults
RT-PCR 35
cDNA source data(1)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(1) Primer pair(1) Other(2)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000021550 (Evidence)
Ensembl Gene ModelENSMUSG00000048480 (Evidence)
Entrez Gene227288 (Evidence)
UniGene337035
DFCITC1591834
DoTSDT.103544164, DT.97378082
NIA Mouse Gene IndexU060562
Consensus CDS ProjectCCDS15041.1
International Mouse Knockout Project StatusCxcr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021550 VEGA Gene Model | MGI Sequence Detail 2847 C57BL/6J ±  kb
transcript OTTMUST00000051104 VEGA | MGI Sequence Detail 1125 Not Applicable 
polypeptide OTTMUSP00000024004 VEGA | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR001355 CXC chemokine receptor 1
InterPro IPR000174 CXC chemokine receptor 1/2
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001256 C-X-C chemokine receptor type 1
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:185240 Lefebvre S, et al., Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012 Apr;132(4):1094-102
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory