Cxcr1
Gene Detail

Symbol Name ID

Cxcr1 chemokine (C-X-C motif) receptor 1 MGI:2448715

Synonyms

Il8ra

Feature Type

protein coding gene

Genetic Map

Chromosome 1

38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:74191785-74194631 bp, - strand From VEGA annotation of GRCm38   2847 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Cxcr1 ± 2 cM)

Protein SuperFamily: chemokine receptor
Gene Tree: Cxcr1

Human ortholog

CXCR1 chemokine (C-X-C motif) receptor 1 NCBI Gene ID 3577
Human Synonyms: C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
Human Chr2:219027568-219031716 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CXCR1 (1)

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Mice homozygous for a gene disruption display normal morphology, clinical chemistry, hematology, and behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cell surface receptor signaling pathway, chemokine-mediated signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	chemokine binding, C-X-C chemokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (35)    Tissues (35)    Images (1)
Theiler Stages: 28

Assay Type	Results
RT-PCR	35

cDNA source data(1)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(1) Primer pair(1) Other(2)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000021550 (Evidence)
Ensembl Gene Model	ENSMUSG00000048480 (Evidence)
Entrez Gene	227288 (Evidence)
UniGene	337035
DFCI	TC1591834
DoTS	DT.103544164, DT.97378082
NIA Mouse Gene Index	U060562
Consensus CDS Project	CCDS15041.1
International Mouse Knockout Project Status	Cxcr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021550	VEGA Gene Model | MGI Sequence Detail	2847	C57BL/6J
transcript	OTTMUST00000051104	VEGA | MGI Sequence Detail	1125	Not Applicable
polypeptide	OTTMUSP00000024004	VEGA | MGI Sequence Detail	351	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(43 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000174	CXC chemokine receptor/Interleukin-8 receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001256	high affinity interleukin-8 receptor A

References

(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:185240 Lefebvre S, et al., Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012 Apr;132(4):1094-102
All references(28)