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Afmid Gene Detail
Summary
  • Symbol
    Afmid
  • Name
    arylformamidase
  • Synonyms
    9030621K19Rik, formylase, formylkynureninase, Kf, kynurenine formamidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448704
    NCBI Gene: 71562
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117716750-117730734 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 82.96 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1005 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448704
 protein coding gene Chr11:117716329-117730734 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019455
 protein coding gene Chr11:122108165-122124027 (+)
A/J MGP_AJ_G0019423
 protein coding gene Chr11:116697954-116712256 (+)
AKR/J MGP_AKRJ_G0019393
 protein coding gene Chr11:120251141-120266178 (+)
BALB/cJ MGP_BALBcJ_G0019398
 protein coding gene Chr11:117069119-117083034 (+)
C3H/HeJ MGP_C3HHeJ_G0019204
 protein coding gene Chr11:120533467-120550226 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019847
 protein coding gene Chr11:125833943-125849815 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017472
 protein coding gene Chr11:113705490-113719771 (+)
CAST/EiJ MGP_CASTEiJ_G0018758
 protein coding gene Chr11:121959544-121973158 (+)
CBA/J MGP_CBAJ_G0019175
 protein coding gene Chr11:130788687-130805768 (+)
DBA/2J MGP_DBA2J_G0019287
 protein coding gene Chr11:116098752-116112846 (+)
FVB/NJ MGP_FVBNJ_G0019279
 protein coding gene Chr11:115717684-115732039 (+)
LP/J MGP_LPJ_G0019357
 protein coding gene Chr11:122433003-122448032 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019312
 protein coding gene Chr11:129749152-129763985 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019886
 protein coding gene Chr11:120900728-120916957 (+)
PWK/PhJ MGP_PWKPhJ_G0018524
 protein coding gene Chr11:117454030-117470018 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018316
 protein coding gene Chr11:120629689-120645790 (+)
WSB/EiJ MGP_WSBEiJ_G0018810
 protein coding gene Chr11:120866506-120880644 (+)



Homology
more
  • Human Ortholog
    AFMID, arylformamidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AFMID, arylformamidase
  • Synonyms
    FKF, KF, KFA
  • Links
    NCBI Gene ID: 125061
    UniProt: Q63HM1

  • Chr Location
    17q25.3; chr17:78187358-78207702 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit polydipsia, polyuria and hyperglycemia. Mice homozygous for a full exon 2 deletion show impaired glucose tolerance due to reduced insulin secretion associated with reduced islet mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    811
  • Tissues
    102
  • cDNA Data
    51
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017718 Ensembl Gene Model | MGI Sequence Detail 13985 C57BL/6J ±  kb
    transcript ENSMUST00000149668 Ensembl | MGI Sequence Detail 1583 Not Applicable  
    polypeptide ENSMUSP00000119310 Ensembl | MGI Sequence Detail 363 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918812
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 16
    • Earliest
      J:52807 Dobrovolsky VN, et al., Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene. Mutat Res. 1999 Jan 25;423(1-2):125-36
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory