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Ythdc2 Gene Detail
Summary
  • Symbol
    Ythdc2
  • Name
    YTH domain containing 2
  • Synonyms
    3010002F02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448561
    NCBI Gene: 240255
  • Gene Overview
    MyGene.info: YTHDC2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:44827746-44889724 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 23.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    543 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448561
protein coding gene Chr18:44821774-44889724 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024402
protein coding gene Chr18:43593350-43654393 (+)
A/J MGP_AJ_G0024369
protein coding gene Chr18:42029169-42090949 (+)
AKR/J MGP_AKRJ_G0024338
protein coding gene Chr18:43209564-43272817 (+)
BALB/cJ MGP_BALBcJ_G0024369
protein coding gene Chr18:42124819-42192139 (+)
C3H/HeJ MGP_C3HHeJ_G0024136
protein coding gene Chr18:43258485-43327373 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024813
protein coding gene Chr18:45086257-45159500 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022248
protein coding gene Chr18:41803923-41860171 (+)
CAST/EiJ MGP_CASTEiJ_G0023610
protein coding gene Chr18:43241939-43310323 (+)
CBA/J MGP_CBAJ_G0024105
protein coding gene Chr18:46337215-46399649 (+)
DBA/2J MGP_DBA2J_G0024235
protein coding gene Chr18:41629442-41689898 (+)
FVB/NJ MGP_FVBNJ_G0024201
protein coding gene Chr18:41236704-41297675 (+)
LP/J MGP_LPJ_G0024319
protein coding gene Chr18:43638608-43707990 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024232
protein coding gene Chr18:47689075-47756203 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024860
protein coding gene Chr18:43093048-43155260 (+)
PWK/PhJ MGP_PWKPhJ_G0023354
protein coding gene Chr18:41830695-41991574 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023159
protein coding gene Chr18:43303765-43469170 (+)
WSB/EiJ MGP_WSBEiJ_G0023673
protein coding gene Chr18:43002692-43068258 (+)



Homology
more
  • Human Ortholog
    YTHDC2, YTH domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    YTHDC2, YTH domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAHL, hYTHDC2
  • Links
    NCBI Gene ID: 64848
    neXtProt AC: NX_Q9H6S0
    UniProt: Q9H6S0

  • Chr Location
    5q22.2; chr5:113513683-113595287 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11265
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: YTHDC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 6 alleles in 5 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female and male infertility with arrested meiosis and small gonads.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034653 Ensembl Gene Model | MGI Sequence Detail 61979 C57BL/6J ±  kb
transcript ENSMUST00000037763 Ensembl | MGI Sequence Detail 7215 Not Applicable  
polypeptide ENSMUSP00000048340 Ensembl | MGI Sequence Detail 1445 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    cDNA 35
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:1917469
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:256276 Jain D, et al., ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2. Elife. 2018 Jan 23;7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory