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Ythdc2 Gene Detail
Summary
  • Symbol
    Ythdc2
  • Name
    YTH domain containing 2
  • Synonyms
    3010002F02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448561
    NCBI Gene: 240255
  • Gene Overview
    MyGene.info: YTHDC2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:44827746-44889724 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      61979 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 23.81 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    YTHDC2, YTH domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    YTHDC2, YTH domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAHL
  • Links
    NCBI Gene ID: 64848
    neXtProt AC: NX_Q9H6S0
    UniProt: Q9H6S0

  • Chr Location
    5q22.2; chr5:113513683-113595287 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11265
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: YTHDC2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 6 alleles in 5 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit female and male infertility with arrested meiosis and small gonads.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055570 VEGA Gene Model | MGI Sequence Detail 61979 C57BL/6J ±  kb
transcript OTTMUST00000137532 VEGA | MGI Sequence Detail 7215 Not Applicable  
polypeptide OTTMUSP00000072416 VEGA | MGI Sequence Detail 1445 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    543 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 34

    Microarray probesets 2
Other
Accession IDs
less
MGI:1917469
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:243743 Hsu PJ, et al., Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Res. 2017 Sep;27(9):1115-1127

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/16/2018
MGI 6.11
The Jackson Laboratory