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Cdk10
Gene Detail
Symbol

Name
ID
Cdk10
cyclin-dependent kinase 10
MGI:2448549
Feature Type
protein coding gene
Genetic Map
Chromosome 8
72.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:123224841-123232250 bp, + strand
From Ensembl annotation of GRCm38

  7410 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55769  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDK10
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk10

Human
homologs
CDK10, cyclin-dependent kinase 10
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8558
neXtProt AC: NX_Q15131

Human Synonyms: PISSLRE

Human Chr (Location): 16q24; chr16:89672247-89696364 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cdk10 interacts with 54 markers (Mir18, Mir18b, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process phosphorylation, positive regulation of MAPK cascade, ...
Component intracellular, nucleus
Function ATP binding, cyclin-dependent protein kinase activity, ...
External Resources: FuncBase
Expression
cDNA source data(69)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdk10 ; ZFIN cdk10    NEW 
Molecular
reagents
All nucleic(69) cDNA(69)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000033862 (Evidence)
Entrez Gene 234854 (Evidence)
UniGene 190984
DFCI TC1603142, TC1659230, TC1602182, TC1578367
NIA Mouse Gene Index U009932, U000118
EC 2.7.11.22
Consensus CDS Project CCDS22751.1
International Mouse Phenotyping Consortium Status Cdk10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033862 Ensembl Gene Model | MGI Sequence Detail 7410 C57BL/6J ±  kb
transcript ENSMUST00000036880 Ensembl | MGI Sequence Detail 1643 Not Applicable 
polypeptide ENSMUSP00000045527 Ensembl | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005252 cyclin-dependent kinase 10
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:202961 Guen VJ, et al., CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19525-30
All references(26)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory