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Cdk10 Gene Detail
Summary
  • Symbol
    Cdk10
  • Name
    cyclin-dependent kinase 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448549
    NCBI Gene: 234854
  • Gene Overview
    MyGene.info: CDK10
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123224842-123232250 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 72.09 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448549
protein coding gene Chr8:123224819-123232258 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034247
protein coding gene Chr8:126825445-126832860 (+)
A/J MGP_AJ_G0034227
protein coding gene Chr8:121571414-121579345 (+)
AKR/J MGP_AKRJ_G0034154
protein coding gene Chr8:125104132-125108878 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0033931
protein coding gene Chr8:125804632-125812719 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034740
protein coding gene Chr8:131067886-131077301 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031682
protein coding gene Chr8:114392306-114399670 (+)
CAST/EiJ MGP_CASTEiJ_G0033259
protein coding gene Chr8:125885717-125893484 (+)
CBA/J MGP_CBAJ_G0033904
protein coding gene Chr8:135874699-135886778 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0034004
protein coding gene Chr8:119913189-119924480 (+)
LP/J MGP_LPJ_G0034150
protein coding gene Chr8:126956560-126966517 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034051
protein coding gene Chr8:138020694-138028661 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034759
protein coding gene Chr8:125315125-125326388 (+)
PWK/PhJ MGP_PWKPhJ_G0032960
protein coding gene Chr8:120582490-120589439 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032800
protein coding gene Chr8:124034314-124038651 (+)
WSB/EiJ MGP_WSBEiJ_G0033375
protein coding gene Chr8:126049847-126058946 (+)



Homology
more
  • Human Ortholog
    CDK10, cyclin dependent kinase 10
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDK10, cyclin dependent kinase 10
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALSAS, PISSLRE
  • Links
    NCBI Gene ID: 8558
    neXtProt AC: NX_Q15131
    UniProt: Q15131

  • Chr Location
    16q24.3; chr16:89686612-89696364 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit severe growth retardation, neonatal lethality, spine malformations and defects in lung, heart, liver and spleen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033862 Ensembl Gene Model | MGI Sequence Detail 7409 C57BL/6J ±  kb
transcript ENSMUST00000036880 Ensembl | MGI Sequence Detail 1642 Not Applicable  
polypeptide ENSMUSP00000045527 Ensembl | MGI Sequence Detail 360 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 70
    cDNA 70

    Microarray probesets 4
References
more
  • Summaries
    All 28
    Gene Ontology 7
    Phenotypes 2
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:262333 Windpassinger C, et al., CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays. Am J Hum Genet. 2017 Sep 7;101(3):391-403

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory