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Cdk10
Gene Detail
 Symbol
Name
ID
Cdk10
cyclin-dependent kinase 10
MGI:2448549
Feature Type protein coding gene
Genetic Map
Chromosome 8
72.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:123224841-123232250 bp, + strand
From Ensembl annotation of GRCm38

  7410 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55769  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk10

Human
homologs
Human Homolog CDK10, cyclin-dependent kinase 10
NCBI Gene ID 8558
neXtProt AC  NX_Q15131
Human Synonyms  PISSLRE
Human Chr (Location)  16q24; chr16:89680737-89696364 (+)  GRCh38
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process phosphorylation, positive regulation of MAPK cascade, ...
Component intracellular, nucleus
Function ATP binding, cyclin-dependent protein kinase activity, ...
External Resources: FuncBase
Expression
cDNA source data(69)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(69) cDNA(69)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000033862 (Evidence)
Entrez Gene234854 (Evidence)
UniGene190984
DFCITC1578367, TC1602182, TC1603142, TC1659230
NIA Mouse Gene IndexU000118, U009932
EC2.7.11.22
Consensus CDS ProjectCCDS22751.1
International Mouse Knockout Project StatusCdk10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033862 Ensembl Gene Model | MGI Sequence Detail 7410 C57BL/6J ±  kb
transcript ENSMUST00000036880 Ensembl | MGI Sequence Detail 1643 Not Applicable 
polypeptide ENSMUSP00000045527 Ensembl | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005252 cyclin-dependent kinase 10
References (Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:202961 Guen VJ, et al., CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19525-30
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory