Pip4p1 MGI Mouse Gene Detail - MGI:2448501 - phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1

Symbol

Pip4p1
Name

phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
Synonyms

Tmem55b

Feature Type

protein coding gene
IDs

MGI:2448501
NCBI Gene: 219024
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:51164672-51168306 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.30 cM
Mapping Data

1 experiment

SNPs within 2kb

33 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448501	protein coding gene	Chr14:51163525-51168313 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021264	protein coding gene	Chr14:44880980-44884623 (-)
A/J	MGP_AJ_G0021218	protein coding gene	Chr14:43543351-43546994 (-)
AKR/J	MGP_AKRJ_G0021194	protein coding gene	Chr14:45187214-45190857 (-)
BALB/cJ	MGP_BALBcJ_G0021221	protein coding gene	Chr14:43658457-43662100 (-)
C3H/HeJ	MGP_C3HHeJ_G0021003	protein coding gene	Chr14:45011228-45014871 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021657	protein coding gene	Chr14:46716053-46719699 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019210	protein coding gene	Chr14:42873788-42877460 (-)
CAST/EiJ	MGP_CASTEiJ_G0020527	protein coding gene	Chr14:42069706-42073412 (-)
CBA/J	MGP_CBAJ_G0020970	protein coding gene	Chr14:48200114-48203757 (-)
DBA/2J	MGP_DBA2J_G0021094	protein coding gene	Chr14:43435170-43438813 (-)
FVB/NJ	MGP_FVBNJ_G0021075	protein coding gene	Chr14:43061652-43065295 (-)
LP/J	MGP_LPJ_G0021162	protein coding gene	Chr14:45174365-45178008 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021103	protein coding gene	Chr14:47683152-47686795 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021687	protein coding gene	Chr14:44673158-44676801 (-)
PWK/PhJ	MGP_PWKPhJ_G0020277	protein coding gene	Chr14:40336563-40340206 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020102	protein coding gene	Chr14:40831927-40835562 (-)
WSB/EiJ	MGP_WSBEiJ_G0020580	protein coding gene	Chr14:44864561-44868204 (-)

Human Ortholog

PIP4P1, phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PIP4P1, phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1
Synonyms

C14orf9, TMEM55B
Links

HGNC:19299

NCBI Gene ID: 90809

neXtProt AC: NX_Q86T03

UniProt: Q86T03
Chr Location

14q11.2; chr14:20457681-20461465 (-) GRCh38

MGI Vertebrate Homology

Pip4p1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PIP4P1
Gene Tree

Pip4p1

less

Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

5
Targeted

2
Genomic Mutations

1 involving Pip4p1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with embryonic growth arrest at E9.5.

less

All GO Annotations

27
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pip4p1

ZFIN pip4p1a

less

All Sequences

76
RefSeq

8
UniProt

6
CCDS

CCDS27028.1, CCDS79322.1, CCDS79323.1, CCDS79324.1

Ensembl

ENSMUSG00000035953 (Evidence)
NCBI Gene

219024

			Length	Strain/Species	Flank
genomic	219024	NCBI Gene Model \| MGI Sequence Detail	3635	C57BL/6J	± kb
transcript	NM_001033271	RefSeq \| MGI Sequence Detail	1623	C57BL/6
polypeptide	Q3TWL2	UniProt \| EBI \| MGI Sequence Detail	284	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000016433 type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

(term hierarchy)
EC

3.1.3.78
InterPro Domains

IPR019178 Phosphatidylinositol 4,5-bisphosphate 4-phosphatase

less

All nucleic 11

cDNA 11

Microarray probesets 3

Summaries

All 34

Gene Ontology 5

Phenotypes 10
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:325207 Qin Y, et al., Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation. Arterioscler Thromb Vasc Biol. 2020 May;40(5):1311-1324

TSS for Pip4p1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr128391	Chr14:51168338-51168347 (-)	-37 bp
Tssr128390	Chr14:51168289-51168335 (-)	-6 bp
Tssr128389	Chr14:51167768-51167786 (-)	529 bp
Tssr128388	Chr14:51167718-51167740 (-)	577 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23