Kdm6b
Gene Detail

Symbol

Name
ID

Kdm6b
KDM1 lysine (K)-specific demethylase 6B
MGI:2448492

Synonyms

Jmjd3, mKIAA0346

Feature Type

protein coding gene

Genetic Map

Chromosome 11
42.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:69398508-69413675 bp, - strand From VEGA annotation of GRCm38   15168 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:18945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Kdm6b

Human
homologs

Human Homolog		KDM6B, lysine (K)-specific demethylase 6B
NCBI Gene ID		23135
neXtProt AC		NX_O15054
Human Synonyms		JMJD3
Human Chr (Location)		17p13.1; chr17:7834203-7854800 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(31) : Gene trapped(21) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit perinatal lethality associated with thick alveolar septum and absences of air space in the lungs. Bone marrow chimera mice derived from fetal liver cells exhibit impaired eosinophil recruitment and abnormal response to helminth infection.

 

Interactions

Kdm6b interacts with 204 markers (Mir7-2, Mir7b, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (31 annotations)

Process	cardiac muscle cell differentiation, cellular response to hydrogen peroxide, ...
Component	nucleus
Function	2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, beta-catenin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	1

cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(8) cDNA(7) Other(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000005979 (Evidence)
Ensembl Gene Model	ENSMUSG00000018476 (Evidence)
Entrez Gene	216850 (Evidence)
DFCI	TC1578227
DoTS	DT.87047344, DT.489544, DT.94197908
NIA Mouse Gene Index	U032962
EC	1.14.11.-
PDB	4EYU, 4EZH, 4EZ4
Consensus CDS Project	CCDS24895.1
International Mouse Knockout Project Status	Kdm6b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005979	VEGA Gene Model | MGI Sequence Detail	15168	C57BL/6J
transcript	OTTMUST00000013375	VEGA | MGI Sequence Detail	6654	Not Applicable
polypeptide	OTTMUSP00000006193	VEGA | MGI Sequence Detail	1641	Not Applicable

All sequences(48) RefSeq(18) UniProt(5)

Polymorphisms

SNPs within 2kb(63 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR003347	JmjC domain
InterPro	IPR011990	Tetratricopeptide-like helical
Protein Ontology	PR:000009217	lysine-specific demethylase 6B

References

(Earliest) J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
(Latest) J:216722 Shpargel KB, et al., KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development. PLoS Genet. 2014 Aug;10(8):e1004507
All references(60)