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Kdm6b
Gene Detail
 Symbol
Name
ID
Kdm6b
KDM1 lysine (K)-specific demethylase 6B
MGI:2448492
Synonyms Jmjd3, mKIAA0346
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:69398508-69413675 bp, - strand
From VEGA annotation of GRCm38

  15168 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18945  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Kdm6b

Human
homologs
Human Homolog KDM6B, lysine (K)-specific demethylase 6B
NCBI Gene ID 23135
neXtProt AC  NX_O15054
Human Synonyms  JMJD3
Human Chr (Location)  17p13.1; chr17:7834203-7854800 (+)  GRCh38
Alleles
and
phenotypes
All alleles(29) : Gene trapped(21) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit perinatal lethality associated with thick alveolar septum and absences of air space in the lungs. Bone marrow chimera mice derived from fetal liver cells exhibit impaired eosinophil recruitment and abnormal response to helminth infection.
 
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular response to hydrogen peroxide, chromatin modification, ...
Component nucleus
Function 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity, C-19 gibberellin 2-beta-dioxygenase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 1
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) cDNA(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005979 (Evidence)
Ensembl Gene ModelENSMUSG00000018476 (Evidence)
Entrez Gene216850 (Evidence)
DFCITC1578227
DoTSDT.489544, DT.87047344, DT.94197908
NIA Mouse Gene IndexU032962
EC1.14.11.-
PDB4EYU, 4EZH, 4EZ4
Consensus CDS ProjectCCDS24895.1
International Mouse Knockout Project StatusKdm6b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005979 VEGA Gene Model | MGI Sequence Detail 15168 C57BL/6J ±  kb
transcript OTTMUST00000013375 VEGA | MGI Sequence Detail 6654 Not Applicable 
polypeptide OTTMUSP00000006193 VEGA | MGI Sequence Detail 1641 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(18) UniProt(3)
Polymorphisms SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003347 JmjC domain
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000009217 lysine-specific demethylase 6B
References (Earliest) J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
(Latest) J:206350 Iwamori N, et al., H3K27 demethylase, JMJD3, regulates fragmentation of spermatogonial cysts. PLoS One. 2013;8(8):e72689
All references(55)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory