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Kdm6b Gene Detail
Summary
  • Symbol
    Kdm6b
  • Name
    KDM1 lysine (K)-specific demethylase 6B
  • Synonyms
    Jmjd3, mKIAA0346
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448492
    NCBI Gene: 216850
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:69398508-69413675 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      15168 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.60 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KDM6B, lysine demethylase 6B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KDM6B, lysine demethylase 6B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JMJD3
  • Links
    NCBI Gene ID: 23135
    neXtProt AC: NX_O15054
    UniProt: O15054

  • Chr Location
    17p13.1; chr17:7834210-7854800 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 8 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    1 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show perinatal death, thick alveolar septum, and absence of air space in the lungs. Mice homozygous for a different null allele die neonatally displaying abnormal lung development, dwarfism, kyphosis, short limbs, and a severe delay in endochondral ossification.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    44
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
    1
  • Tissues
    1
  • cDNA Data
    8
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005979 VEGA Gene Model | MGI Sequence Detail 15168 C57BL/6J ±  kb
    transcript OTTMUST00000013375 VEGA | MGI Sequence Detail 6654 Not Applicable  
    polypeptide OTTMUSP00000006193 VEGA | MGI Sequence Detail 1641 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      78 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 27
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:265480 Seok S, et al., Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid beta-oxidation. J Clin Invest. 2018 Jul 2;128(7):3144-3159
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/16/2018
    MGI 6.12     		The Jackson Laboratory