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Kdm6b Gene Detail
Summary
  • Symbol
    Kdm6b
  • Name
    KDM1 lysine (K)-specific demethylase 6B
  • Synonyms
    Jmjd3, mKIAA0346
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448492
    NCBI Gene: 216850
Location & Maps
more
  • Sequence Map
    Chr11:69398508-69413675 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15168 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KDM6B, lysine (K)-specific demethylase 6B
  • Vertebrate Orthologs
    7
  • Human Ortholog
    KDM6B, lysine (K)-specific demethylase 6B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    JMJD3
  • Links
    NCBI Gene ID: 23135
    neXtProt AC: NX_O15054

  • Chr Location
    17p13.1; chr17:7834200-7854800 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 6 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Targeted
    12
  • Transgenic
    1
  • Genomic Mutations
    1 involving Kdm6b
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit perinatal lethality associated with thick alveolar septum and absences of air space in the lungs. Bone marrow chimera mice derived from fetal liver cells exhibit impaired eosinophil recruitment and abnormal response to helminth infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005979 VEGA Gene Model | MGI Sequence Detail 15168 C57BL/6J ±  kb
transcript OTTMUST00000013375 VEGA | MGI Sequence Detail 6654 Not Applicable  
polypeptide OTTMUSP00000006193 VEGA | MGI Sequence Detail 1641 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 59
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 20
  • Earliest
    J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
  • Latest
    J:227020 Manna S, et al., Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation. Nat Commun. 2015;6:8152

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory