Sbno2 MGI Mouse Gene Detail - MGI:2448490

Symbol

Sbno2
Name

strawberry notch 2
Synonyms

Stno

Feature Type

protein coding gene
IDs

MGI:2448490
NCBI Gene: 216161
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr10:79892826-79941405 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

835 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2448490	protein coding gene	Chr10:79892826-79941942 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017481	protein coding gene	Chr10:80638034-80687959 (-)
A/J	MGP_AJ_G0017459	protein coding gene	Chr10:77817068-77863644 (-)
AKR/J	MGP_AKRJ_G0017420	protein coding gene	Chr10:79942499-79987043 (-)
BALB/cJ	MGP_BALBcJ_G0017421	protein coding gene	Chr10:78040938-78087863 (-)
C3H/HeJ	MGP_C3HHeJ_G0017244	protein coding gene	Chr10:80040864-80089106 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017875	protein coding gene	Chr10:83418195-83468582 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015563	protein coding gene	Chr10:74043478-74088196 (-)
CAST/EiJ	MGP_CASTEiJ_G0016811	protein coding gene	Chr10:80239763-80286840 (-)
CBA/J	MGP_CBAJ_G0017216	protein coding gene	Chr10:86649913-86704086 (-)
DBA/2J	MGP_DBA2J_G0017322	protein coding gene	Chr10:77034380-77078918 (-)
FVB/NJ	MGP_FVBNJ_G0017316	protein coding gene	Chr10:76214354-76260913 (-)
LP/J	MGP_LPJ_G0017393	protein coding gene	Chr10:81114037-81162287 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017342	protein coding gene	Chr10:88606788-88653456 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017916	protein coding gene	Chr10:79919787-79969907 (-)
PWK/PhJ	MGP_PWKPhJ_G0016592	protein coding gene	Chr10:76899908-76946932 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016381	protein coding gene	Chr10:78899520-78950472 (-)
WSB/EiJ	MGP_WSBEiJ_G0016871	protein coding gene	Chr10:79949659-80000596 (-)

Human Ortholog

SBNO2, strawberry notch homolog 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SBNO2, strawberry notch homolog 2
Synonyms

KIAA0963, SNO, STNO
Links

HGNC:29158

NCBI Gene ID: 22904

UniProt: Q9Y2G9
Chr Location

19p13.3; chr19:1107637-1174268 (-) GRCh38

MGI Vertebrate Homology

Sbno2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SBNO2
Gene Tree

Sbno2

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Phenotype Summary

17 phenotypes from 1 allele in 1 genetic background
2 images
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

19
Targeted

2
Genomic Mutations

1 involving Sbno2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

56 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired osteoclast fusion, impaired osteoblastogenesis, osteopetrosis, increased bone mass, and decreased body weight.

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All GO Annotations

37
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

4
cDNA Data

80
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sbno2

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All Sequences

90
RefSeq

35
UniProt

4
CCDS

CCDS24008.1

Ensembl

ENSMUSG00000035673 (Evidence)
NCBI Gene

216161

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035673	Ensembl Gene Model \| MGI Sequence Detail	48580	C57BL/6J	± kb
transcript	ENSMUST00000042771	Ensembl \| MGI Sequence Detail	4227	Not Applicable
polypeptide	ENSMUSP00000041635	Ensembl \| MGI Sequence Detail	1349	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014477 protein strawberry notch homolog 2

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR026741 Protein strawberry notch

IPR039187 Strawberry notch, AAA domain

IPR026937 Strawberry notch, helicase C domain
GlyGen

Q7TNB8 1 site

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All nucleic 80

cDNA 80

Microarray probesets 3

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Sbno2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98399	Chr10:79941903-79941955 (-)	-524 bp
Tssr98398	Chr10:79941502-79941538 (-)	-115 bp
Tssr98397	Chr10:79941420-79941451 (-)	-31 bp
Tssr98396	Chr10:79941400-79941411 (-)	-1 bp
Tssr98395	Chr10:79940168-79940210 (-)	1,216 bp
Tssr98394	Chr10:79940135-79940146 (-)	1,264 bp
Tssr98393	Chr10:79938487-79938562 (-)	2,880 bp
Tssr98392	Chr10:79938474-79938485 (-)	2,925 bp
Tssr98391	Chr10:79936988-79937006 (-)	4,408 bp
Tssr98390	Chr10:79936959-79936973 (-)	4,439 bp
Tssr98389	Chr10:79934377-79934380 (-)	7,026 bp
Tssr98388	Chr10:79916358-79916365 (-)	25,043 bp
Tssr98387	Chr10:79911303-79911312 (-)	30,097 bp
Tssr98386	Chr10:79911245-79911287 (-)	30,139 bp
Tssr98385	Chr10:79911212-79911241 (-)	30,178 bp
Tssr98384	Chr10:79911194-79911211 (-)	30,202 bp
Tssr98383	Chr10:79911109-79911135 (-)	30,283 bp
Tssr98382	Chr10:79910884-79910924 (-)	30,501 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24