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Sbno2 Gene Detail
Summary
  • Symbol
    Sbno2
  • Name
    strawberry notch homolog 2 (Drosophila)
  • Synonyms
    Stno
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448490
    NCBI Gene: 216161
  • Gene Overview
    MyGene.info: SBNO2
Location & Maps
more
  • Sequence Map
    Chr10:80057416-80102698 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45283 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SBNO2, strawberry notch homolog 2 (Drosophila)
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SBNO2, strawberry notch homolog 2 (Drosophila)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KIAA0963, SNO, STNO
  • Links
    NCBI Gene ID: 22904
    neXtProt AC: NX_Q9Y2G9

  • Chr Location
    19p13.3; chr19:1107634-1174283 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8981
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: SBNO2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    2 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Targeted
    1
  • Genomic Mutations
    1 involving Sbno2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired osteoclast fusion, impaired osteoblastogenesis, osteopetrosis, increased bone mass, and decreased body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035673 Ensembl Gene Model | MGI Sequence Detail 45283 C57BL/6J ±  kb
transcript ENSMUST00000042771 Ensembl | MGI Sequence Detail 4227 Not Applicable  
polypeptide ENSMUSP00000041635 Ensembl | MGI Sequence Detail 1349 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    111 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014477 protein strawberry notch homolog 2
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR026741 Protein strawberry notch
    IPR030410 Protein strawberry notch homologue 2
    IPR026937 Strawberry notch, helicase C domain
Molecular
Reagents
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  • All nucleic 79
    cDNA 79

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:223816 Grill M, et al., Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system. Glia. 2015 Oct;63(10):1738-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory