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Mgst2 Gene Detail
Summary
  • Symbol
    Mgst2
  • Name
    microsomal glutathione S-transferase 2
  • Synonyms
    GST2, MGC:41409, MGST-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:2448481
    NCBI Gene: 211666
  • Gene Overview
    MyGene.info: MGST2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:51660360-51682675 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 22.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2448481
protein coding gene Chr3:51660360-51682677 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027200
protein coding gene Chr3:50140884-50166267 (+)
A/J MGP_AJ_G0027160
protein coding gene Chr3:48675985-48698757 (+)
AKR/J MGP_AKRJ_G0027129
protein coding gene Chr3:49643979-49666302 (+)
BALB/cJ MGP_BALBcJ_G0027172
protein coding gene Chr3:48536324-48558623 (+)
C3H/HeJ MGP_C3HHeJ_G0026915
protein coding gene Chr3:49869469-49894617 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027618
protein coding gene Chr3:52158750-52188345 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024978
protein coding gene Chr3:45301370-45326289 (+)
CAST/EiJ MGP_CASTEiJ_G0026368
protein coding gene Chr3:49938351-49959413 (+)
CBA/J MGP_CBAJ_G0026892
protein coding gene Chr3:53783712-53808986 (+)
DBA/2J MGP_DBA2J_G0027026
protein coding gene Chr3:48281129-48303343 (+)
FVB/NJ MGP_FVBNJ_G0026994
protein coding gene Chr3:47262397-47285022 (+)
LP/J MGP_LPJ_G0027138
protein coding gene Chr3:50897356-50922480 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027012
protein coding gene Chr3:57968219-57991471 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027677
protein coding gene Chr3:49571066-49593336 (+)
PWK/PhJ MGP_PWKPhJ_G0026100
protein coding gene Chr3:47934354-47956414 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025913
protein coding gene Chr3:49225468-49247445 (+)
WSB/EiJ MGP_WSBEiJ_G0026442
protein coding gene Chr3:49675023-49700138 (+)



Homology
more
  • Human Ortholog
    MGST2, microsomal glutathione S-transferase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MGST2, microsomal glutathione S-transferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GST2, MGST-II
  • Links
    NCBI Gene ID: 4258
    neXtProt AC: NX_Q99735
    UniProt: Q99735

  • Chr Location
    4q31.1; chr4:139665725-139754546 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1811
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MGST2
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display resistance to induced ER stress related cell death and mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 211666 NCBI Gene Model | MGI Sequence Detail 22316 C57BL/6J ±  kb
transcript NM_174995 RefSeq | MGI Sequence Detail 614 C57BL/6  
polypeptide NP_778160 RefSeq | MGI Sequence Detail 147 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR001446 5-lipoxygenase-activating protein
    IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain superfamily
    IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
  • Latest
    J:228296 Dvash E, et al., Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. Nat Commun. 2015;6:10112

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory